Interaction of cadmium, zinc and copper in relation to smoking habit, age and histopathological findings in human kidney cortex

Blanuša, Maja; Z, Kralj; Bunarević, A

doi:10.1007/bf00348320

Cited by 16 publications

(5 citation statements)

References 15 publications

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“…These ratios are the most important ever reported in the literature: about three to four times more than those from the United Kingdom (Scott et al, 1987), the Federal Republic of Germany (Thurauf et al, 1986;Hahn et al, 1987), or the United States 158 J. L. BENEDETTI ET AL. (Kowal et al, 1979), and about two times higher than those of Denmark (Ostergaard, 1978), Czechoslovakia (Cikrt et al, 1990), and Yugoslavia (Blanusa et al, 1985). In this last country, where a high ratio was found (3.0), cigarettes are among the most contaminated by cadmium in the world (Watanabe et al, 1987).…”

Section: Cadmium In the Organs And Tissues Of Canadians 155mentioning

confidence: 65%

Levels of Cadmium in Kidney and Liver Tissues Among a Canadian Population (Province of Quebec)

Benedetti¹

1999

Journal of Toxicology and Environmental Health, Part A

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In an exploratory study, levels of cadmium in whole-kidney and liver tissues of 314 subjects from the general population of the province of Quebec (Canada) were measured postmortem. Frequency distributions of cadmium concentrations were lognormal. As reported in similar studies, age and especially smoking habits were the main variables affecting cadmium concentrations. The geometric mean of whole kidney concentrations (wet weight) was 17.62 microg/g, with a minimum concentration of 2.25 microg/g and a maximum of 100.61 microg/g. Mean concentrations of cadmium in kidneys increased with age, reaching a plateau in the group 50 to 59 yr (29.49 microg/g), and falling slowly thereafter.

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Section: Cadmium In the Organs And Tissues Of Canadians 155mentioning

confidence: 65%

Levels of Cadmium in Kidney and Liver Tissues Among a Canadian Population (Province of Quebec)

Benedetti¹

1999

Journal of Toxicology and Environmental Health, Part A

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“…It has been shown that following cigarette smoke inhalation, 25-50% of cadmium could be absorbed (ATSDR, 2008), and after oral and dermal exposure 1-10% and <1% of the dose is absorbed, respectively. Data on the Croatian population have shown that non-smokers have cadmium concentrations in blood of less than 1.5 µg l −1 (Jurasović et al, 2004), in kidney cortex ca 20 µg g −1 wet weight (Blanuša et al, 1985) and in placental tissue ca 10-16 ng g −1 wet weight (Piasek et al, 2001; this paper, Table 2). Smokers have up to 5 times higher blood cadmium concentrations, twice as high cadmium concentrations in kidney cortex, and twice as high cadmium concentrations in placental tissue (in Piasek et al, 2007).…”

Section: Cadmium and Human Placentamentioning

confidence: 92%

Metals in human placenta: focus on the effects of cadmium on steroid hormones and leptin

Stasenko

Bradford

Piasek

et al. 2009

J of Applied Toxicology

106

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Cadmium and other metallic ions can act as metalloestrogens and endocrine disruptors of reproductive tissues and fetal development in mammals, including humans. The detrimental effects occur with respect to the synthesis of both steroid and polypeptide hormones in the placenta. Leptin is produced by the trophoblast and may regulate fetal organogenesis and development. In human term placentas, concentrations of toxic metals and their effects on steroidogenesis were assessed in healthy parturients (109 non-smokers and 99 smokers) in relation to tobacco smoking. Trace elements (cadmium, lead, iron, zinc and copper) were analyzed in placentas using atomic absorption spectroscopy, and steroid hormones (progesterone and estradiol) were assayed in placental samples by an enzyme-immunometric method. Cadmium concentrations were doubled in placentas of smokers as compared with non-smokers, and placental lead and zinc concentrations increased significantly. Placental concentrations of iron, copper, progesterone and estradiol did not differ. In addition, human trophoblast cells were co-cultured with 0, 5, 10 or 20 microm CdCl(2) for 96 h and leptin mRNA assessed by quantitative polymerase chain reaction. Leptin mRNA declined dose-responsively as a result of CdCl(2) exposure. Collectively, the results confirm that human placental tissue offers a unique opportunity to biomonitor cadmium exposure in both the maternal and the internal fetal environments. In addition, the results strongly suggest that cadmium may cause a decline in placental leptin synthesis, as we have previously shown for placental progesterone production. This may constitute further evidence of the endocrine-disrupting effects of cadmium, as a constituent of tobacco smoke, on reproduction in women.

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“…Smoking does not affect the Hg levels in urine, hair, blood, kidney cortex, liver and lung. No significant differences due to smoking were found in Cu concentrations in the kidney cortex [16]. Smoking also does not influence the Zn level in most human tissues and biological fluids.…”

mentioning

confidence: 79%

Effect of Active and Passive Smoking on Heavy Metals Toxic and Antioxidant Trace Elements

Viroonudomphol¹,

Suwanton²,

Pinyosirikul³

et al. 2016

JOMB

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Interaction of cadmium, zinc and copper in relation to smoking habit, age and histopathological findings in human kidney cortex

Cited by 16 publications

References 15 publications

Levels of Cadmium in Kidney and Liver Tissues Among a Canadian Population (Province of Quebec)

Levels of Cadmium in Kidney and Liver Tissues Among a Canadian Population (Province of Quebec)

Metals in human placenta: focus on the effects of cadmium on steroid hormones and leptin

Effect of Active and Passive Smoking on Heavy Metals Toxic and Antioxidant Trace Elements

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