Interaction of calcium sulfate with xanthan gum: Effect on in vitro bioadhesion and drug release behavior from xanthan gum based buccal discs of buspirone

Jaipal, A.; Pandey, Murali Monohar; Abhishek, A.; Vinay, S. P.; Charde, Shrikant Y.

doi:10.1016/j.colsurfb.2013.06.052

Cited by 33 publications

(22 citation statements)

References 67 publications

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“…This signifies that diffusion, polymer erosion and relaxation are the predominant mechanisms of drug release; this finding has also been reported in other literature sources 4,9,[10][11]30 . According to Baumgartner et al, (2008) the higher the ionic strength the more pronounced the contribution of Fickian diffusion 10 ; thus F1 obtained the lowest value because the formulation had the greatest calcium ion content.…”

supporting

confidence: 71%

“…Drug release from XG matrix tablets is also sensitive to the presence of ions in the release medium; this is of particular importance because the ionic strength of the GI fluid varies calcium ions within the matrix tablet increases, drug release also increases [10][11] . The effect of bivalent cations on the flow behaviour of XG solutions has been investigated in several studies 3,10,[12][13] .…”

Section: Xanthomonas Compestrismentioning

confidence: 99%

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Incorporation of calcium salts into xanthan gum matrices: hydration, erosion and drug release characteristics

Groves

Chaw

2014

Drug Development and Industrial Pharmacy

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Xanthan gum, a hydrophilic biopolymer with modified release properties, was used to produce directly compressed matrix tablets containing a model drug, Sodium paminosalicylate. Three formulations were prepared, each containing a different calcium dihydrate salt: Calcium Chloride, Calcium Sulfate or Dibasic Calcium Phosphate. The aim of the investigation was to relate the calcium ion content and solubility of the calcium salt to the in vitro drug release profile of the xanthan matrices. Tablet hydration, erosion and drug release were determined in distilled water using the BP paddle method. The data showed that the overall drug release was the greatest with addition of calcium Sulfate, followed by Calcium Chloride and dibasic Calcium Phosphate. The chloride salt formulation displayed the greatest percentage erosion due to rapid mass loss during the initial phase, followed by those with sulfate or phosphate salts. As xanthan gel viscosity increased and drug release was also found to be lower. It can be concluded that drug release is influenced by the solubility of the salt present in the formulation, since these parameters determine the viscosity and structure of the gel layer.

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supporting

confidence: 71%

Section: Xanthomonas Compestrismentioning

confidence: 99%

Incorporation of calcium salts into xanthan gum matrices: hydration, erosion and drug release characteristics

Groves

Chaw

2014

Drug Development and Industrial Pharmacy

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“…Variety of dosage forms like tablets (Boyapally et al, 2010, Kanjanabat & Pongjanyakul, 2011, discs (Yehia et al, 2008;Jaipal et al, 2013), patches (Abu-Huwaij et al, 2011;Kaur & Kaur, 2012;Govindasamy et al, 2013) and gels (Das et al, 2012;Bueno et al, 2013) have been reported in the literature for buccal delivery of drugs. Buccal discs are flat, thin solid unit non-flexible compacts; and are similar to buccal tablets.…”

Section: Introductionmentioning

confidence: 99%

“…Buccal discs are designed to minimize the discomfort caused due to bulky tablet buccal dosage forms. Several buccal discs have been extensively reported for successful delivery of therapeutic drug molecules (Han et al, 1999;El-Samaligy et al, 2004;Yehia et al, 2008;Jaipal et al, 2013;Sander et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Controlled release effervescent buccal discs of buspirone hydrochloride:in vitroandin vivoevaluation studies

Jaipal

Pandey

et al. 2014

Drug Delivery

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“…However, results show significant superior bioadhesive strength for HPMC-coated liposomes compared to chitosan-coated liposomes (Table 1). HPMC is a nonionic hydrophilic polymer, the mucoadhesive performance of which relies mainly on the interpenetration of polymer chains and mucin molecules and on the formation of strong hydrogen bonding (Jaipal et al, 2013). The greater mucoadhesive performance of HPMC is probably attributed to its high molecular weight, which was indicated by the high viscosity of the polymer solution.…”

Section: Bioadhesion Studymentioning

confidence: 99%

Development and characterization of polymer-coated liposomes for vaginal delivery of sildenafil citrate

2017

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Vaginal administration of sildenafil citrate has shown recently to develop efficiently the uterine lining with subsequent successful embryo implantation following in vitro fertilization. The aim of the present study was to develop sildenafil-loaded liposomes coated with bioadhesive polymers for enhanced vaginal retention and improved drug permeation. Three liposomal formulae were prepared by thin-film method using different phospholipid:cholesterol ratios. The optimal liposomal formulation was coated with bioadhesive polymers (chitosan and HPMC). A marked increase in liposomal size and zeta potential was observed for all coated liposomal formulations. HPMC-coated liposomes showed the greater bioadhesion and higher entrapment efficiency than chitosan-coated formulae. The in vitro release studies showed prolonged release of sildenafil from coated liposomes as compared to uncoated liposomes and sildenafil solution. Ex vivo permeation study revealed the enhanced permeation of coated relative to uncoated liposomes. Chitosan-coated formula demonstrated highest drug permeation and was thus selected for further investigations. Transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR) confirmed the successful coating of the liposomes by chitosan. Histopathological in vivo testing proved the efficacy of chitosan-coated liposomes to improve blood flow to the vaginal endometrium and to increase endometrial thickness. Chitosan-coated liposomes can be considered as potential novel drug delivery system intended for the vaginal administration of sildenafil, which would prolong system's retention at the vaginal site and enhance the permeation of sildenafil to uterine blood circulation.

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Interaction of calcium sulfate with xanthan gum: Effect on in vitro bioadhesion and drug release behavior from xanthan gum based buccal discs of buspirone

Cited by 33 publications

References 67 publications

Incorporation of calcium salts into xanthan gum matrices: hydration, erosion and drug release characteristics

Incorporation of calcium salts into xanthan gum matrices: hydration, erosion and drug release characteristics

Controlled release effervescent buccal discs of buspirone hydrochloride:in vitroandin vivoevaluation studies

Development and characterization of polymer-coated liposomes for vaginal delivery of sildenafil citrate

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