Interaction of Chromium(III) Complex of Glycylphenylalanine with Ninhydrin in Aqueous and Cetyltrimethylammonium Bromide (CTAB) Micellar Media

2016

J. Phys. Org. Chem.

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121

Micellization (aggregation) phenomenon of amphiphilic phenothiazine drug promazine hydrochloride (PMZ) and sodium dodecylbenzenesulfonate (SDBS) mixtures in absence and attendance of 50 mmol•kg À1 NaCl (salt)/300 mmol•kg À1 urea was investigated conductometrically at five various temperatures (293.15-318.15 K) at gaps of T = 5 K. PMZ is employed for the cure of mania and schizophrenia. The critical micelle concentration (CMC) values have been evaluated and defined in terms of hydrophobicity and hydrophilicity of PMZ and SDBS in aqueous and nonaqueous solutions. With increasing the temperature, the CMC first increases then decreases. At 303.15 K, the maximum CMC values were obtained in absence and presence of NaCl/urea. NaCl reduces the CMC of pure amphiphiles and their mixtures while urea increases. Various physicochemical parameters such as CMC id (ideal critical micelle concentration), micellar mole fraction of SDBS (X 1 ) (calculated by different proposed models), and interaction parameter have been evaluated and discussed in detail. The values of degree of dissociation (g) and CMC of the micelles were utilized to evaluate the different thermodynamic parameters. Activity coefficients (f 1 and f 2 ) and excess free energy of micellization (ΔG ex ) values were also evaluated. All outcomes obtained herein show attractive interactions in the mixtures of PMZ and SDBS.

Section: Introductionmentioning

confidence: 99%

Aggregation behavior of amphiphilic drug promazine hydrochloride and sodium dodecylbenzenesulfonate mixtures under the influence of NaCl/urea at various concentration and temperatures

2016

J. Phys. Org. Chem.

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121

“…According to the scheme, nucleophilic attack is not possible because the lone pair of electrons is not available in the zinc‐glycylglycine complex. Therefore, reaction starts through condensation of coordinated ninhydrin within the coordination sphere of metal ions (Kabir‐ud‐Din et al, ; Kumar et al, ; Kumar and Rub, ; Rafiquee et al, ). Therefore, the reaction occurs through inner sphere complexation on [Zn(II)‐Gly‐Gly] + with ninhydrin.…”

Section: Resultsmentioning

confidence: 99%

Interaction of Metal Ion‐Coordinated Dipeptide Complex and Ninhydrin in the Alkanediyl‐α,ω‐bis‐Type Gemini Surfactant System

2019

J Surfact & Detergents

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In the current study, interaction of a metal ion‐coordinated dipeptide complex and ninhydrin was examined in the alkanediyl‐α,ω‐bis‐type gemini surfactant system. This work was performed as a function of reactants (ninhydrin and metal‐dipeptide complex), surfactants, temperature, and pH. Different techniques including UV–vis spectrophotometry were used to carry out the experiments. The kψ–values were evaluated in the presence of alkanediyl‐α,ω‐bis‐type gemini surfactants. A first‐order path in the metal‐dipeptide complex and a fractional‐order path in ninhydrin were noticed. To illustrate the quantitative analysis of kψ–[gemini] profiles, a pseudophase model of micelles was employed. Thermodynamic parameters were also evaluated and explained. By the observed outcomes, a probable mechanism was suggested and discussed in detail.

“…In the present case, this lone pair is not free. Therefore, condensation of the coordinated amino group of Gly-Tyr to the coordinated carbonyl group of ninhydrin occurs within the coordination sphere of copper(II) as shown in Scheme 1, which is an example of a template mechanism [19][20][21].…”

Section: Effect Of Temperature On the Reaction Ratementioning

confidence: 99%

“…Kabir-ud-Din et al has studied ninhydrin-amino acid reactions and found that the effect of surfactants, solvents and coordination to metal salts increases the rate of color formation [15][16][17]. However, studies on the reaction rate of ninhydrin-peptide have not attracted much attention [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Effect of Alkanediyl‐α,ω‐Type Cationic Dimeric (Gemini) Surfactants on the Reaction Rate of Ninhydrin with [Cu(II)‐Gly‐Tyr]⁺ Complex

Neo

2015

J Surfact & Detergents

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The effect of gemini (16‐s‐16, s = 4, 5, 6) surfactants on the reaction rate of ninhydrin with [Cu(II)‐Gly‐Tyr]+ complex was determined using a spectrophotometric technique. The ninhydrin concentration was kept in excess in order to maintain pseudo‐first‐order conditions. The reaction followed irreversible first‐ and fractional‐order kinetics with respect to [Cu(II)‐Gly‐Tyr]+ and [ninhydrin], respectively. It is found that gemini surfactants effectively catalyze the reaction. The rate constants (kψ) first increase and then become relatively constant with increasing gemini surfactant concentration similar to conventional cetyltrimethylammonium bromide. At higher gemini surfactant concentration a third region of increasing kψ is observed. The unusual third region is ascribed to changes in micellar morphology. The kinetic data has been analyzed using a micellar pseudo‐phase model.