Interaction of Copper Oxide Nanoparticles With Bovine Serum Albumin by Spectroscopic Studies

Abraham, S. Daniel; Parthasarathy, V.

doi:10.22159/ijpps.2018v10i5.24877

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…210-3119. Moreover, the rate of carbonation rises with an increasing surface area due to the rapid reaction of CaCO 3 [ 72 , 73 ]. Accordingly, XRD analysis confirms the formation of a Cr 2 O 3 /CaCO 3 nanocomposite catalyst.…”

Section: Resultsmentioning

confidence: 99%

A High-Performance Cr2O3/CaCO3 Nanocomposite Catalyst for Rapid Hydrogen Generation from NaBH4

Alshammari,

Alhassan

et al. 2024

Nanomaterials

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This study aims to prepare new nanocomposites consisting of Cr2O3/CaCO3 as a catalyst for improved hydrogen production from NaBH4 methanolysis. The new nanocomposite possesses nanoparticles with the compositional formula Cr2−xCaxO3 (x = 0, 0.3, and 0.6). These samples were prepared using the sol-gel method, which comprises gelatin fuel. The structure of the new composites was studied using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, environmental scanning electron microscopy (ESEM), and X-ray spectroscopy (XPS). The XRD data showed the rhombohedral crystallinity of the studied samples, and the average crystal size was 25 nm. The FTIR measurements represented the absorption bands of Cr2O3 and CaO. The ESEM micrographs of the Cr2O3 showed the spherical shape of the Cr2O3 nanoparticles. The XPS measurements proved the desired oxidation states of the Cr2−xCaxO3 nanoparticles. The optical band gap of Cr2O3 is 3.0 eV, and calcium doping causes a reduction to 2.5 and 1.3 eV at 15.0 and 30.0% doping ratios. The methanolysis of NaBH4 involved accelerated H2 production when using Cr2−xCaxO3 as a catalyst. Furthermore, the Cr1.7Ca0.3O3 catalyst had the highest hydrogen generation rate, with a value of 12,750 mL/g/min.

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Section: Resultsmentioning

confidence: 99%

A High-Performance Cr2O3/CaCO3 Nanocomposite Catalyst for Rapid Hydrogen Generation from NaBH4

Alshammari,

Alhassan

et al. 2024

Nanomaterials

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“…Reversible generally involves weak chemical bonds such as Hydrogen bonds, hydrophobic bonds, Ionic bonds, Vander waals forces. Irreversible drug binding results from covalent binding and is frequently the cause of the drug's carcinogenicity or tissue toxicity (11)(12)(13) .…”

Section: Drug -Protein Interactionsmentioning

confidence: 99%

Interaction study of 5- Fluorouracil with Bovine serum albumin by UV-Visible spectrophotometry

Sajna John,

Gopika VC,

Sadiyath mol VP

et al. 2023

World J. Bio. Pharm. Health Sci.

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Introduction: 5-Fluorouracil (5-FU) is primary chemotherapeutic drug used for most colorectal, pancreatic and aggressive forms of breast cancers. Serum albumin is major carrier protein and its binding with drugs is important to examine the change in pharmacokinetic properties which directly influence the bio availability, sustained drug release and toxicity of drugs. Aim and objectives: The aim of the project is to perform a study on interaction of 5 - fluorouracil with bovine serum albumin employing the UV-Visible spectrophotometric method. Methods: Interaction of 5-FU with BSA has been studied systematically using UV spectroscopy by fixing the carbonate buffer of pH 7.4 as solvent and at a suitable wavelength 230 nm and 275 nm. To gain an insight into the interaction of 5-FU with BSA, the spectra of the 5-FU and BSA were examined in the absence and presence of various concentrations of the 5-FU and BSA respectively at zero minutes and repeated in 30 minutes, 60 minutes and 90 minutes time interval. The changes in peak intensity, absorbance and shift in peaks were observed. The detectable differences were recorded. This method can be used successfully for the interaction study of 5-FU with BSA. Results: Interaction study of 5-Fluorouracil with bovine serum albumin revealed that appreciable changes in absorbance, peak area and shifts in peak were observed which may be due to binding of drug with protein BSA.

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Mechanistic interaction studies of synthesized ZIF-8 nanoparticles with bovine serum albumin using spectroscopic and molecular docking approaches

Mittal

Gandhi

Roy

2022

Sci Rep

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Numerous studies have shown that nanosized zeolitic imidazolate framework particles (ZIF-8 NPs) serve as promising vehicles for pH-responsive drug delivery. An understanding of their interaction with serum proteins present in physiological systems will thus be of critical importance. In this work, monodisperse ZIF-8 NPs with an average size of 60 nm were synthesized at room temperature and characterized for their various physicochemical properties. Bovine serum albumin (BSA) was used as model serum protein for various interaction studies with ZIF-8 NPs. Spectroscopic techniques such as UV–visible and fluorescence spectroscopy indicated the formation of a ground-state complex with a binding constant of the order 103 M−1 and a single binding site. Steady-state and time-resolved fluorescence spectroscopy confirmed the mechanism of quenching to be static. Conformational changes in the secondary structure of BSA were observed using CD and FT-IR spectroscopies. Binding sites were explored using molecular docking studies.

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Interaction of Copper Oxide Nanoparticles With Bovine Serum Albumin by Spectroscopic Studies

Cited by 3 publications

References 30 publications

A High-Performance Cr2O3/CaCO3 Nanocomposite Catalyst for Rapid Hydrogen Generation from NaBH4

A High-Performance Cr2O3/CaCO3 Nanocomposite Catalyst for Rapid Hydrogen Generation from NaBH4

Interaction study of 5- Fluorouracil with Bovine serum albumin by UV-Visible spectrophotometry

Mechanistic interaction studies of synthesized ZIF-8 nanoparticles with bovine serum albumin using spectroscopic and molecular docking approaches

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