Interaction of curcumin with a winter flounder alpha-helical antifreeze protein

Sands, Dane; Carsky, Melissa; Donovan, Erin; Virgilio, Lara L.; Ewart, K. Vanya

doi:10.1016/j.bbrc.2022.09.052

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…Curcumin derivatives show antioxidant, anti-diabetic, anticancer, anti-allergic, anticoagulant, antifungal, and disinfectant properties (Orellana-Paucar and Machado-Orellana 2022;Salem et al 2022). However, its limited aqueous solubility and instability under physiological conditions prevent its widespread use in clinical settings (Kharat et al 2017;Sands et al 2022). Therefore, many researchers have tried different methods to reinforce their bioavailability (Verma et al 2022).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, theoretical analysis, and biological properties of a novel tridentate Schiff base palladium (II) complex

Jahangiry,

Lashanizadegan,

Pourhosseini

et al. 2024

Biometals

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Schiff base complexes play a crucial role in bioinorganic chemistry. A novel curcumin/phenylalanine tridentate Schiff base ligand and its palladium (II) complex were synthesized in order that they were stable in aqueous buffer. The structure of the complex was investigated using a variety of methods, including DFT, NBO analysis, FMOs, and MESP. The interaction of the complex with plasmid (pUC19) and CT-DNA was studied. The anticancer, antibacterial, and antioxidant activities of the complex were examined. The statistical analysis of MTT assay was compared using the 1-way ANOVA and Tukey test. Results showed that the complexes were stable in aqueous buffer, pH 8. The extrinsic fluorescence emission of the plasmid and CT-DNA was quenched while interacting with the complex. The complex had an IC50 of 72.47 μM against MCF-7 cells. The ANOVA and Tukey analysis of MTT data demonstrated a statistically significant difference between groups (P<0.0001). The minimum inhibitory concentrations (MIC) of the complex for E. coli and S. aureus were 300 and 200 μg/mL, with 96.3 % and 95.2 % biofilm growth inhibition at 250 μg/mL, respectively. The sample concentrations contributing to 50% radical inhibition in the 1,1-diphenyl-2picrylhydrazyl (DPPH) test for curcumin, ligand, and palladium (II) complex were 33.62, 21.27, and 51.26 μM, respectively. The results suggest that the complex interaction with DNA is one of the potential mechanisms in the elimination of cancer cells and bacteria in the planktonic and biofilm. On the other hand, while stability in aqueous buffer at pH 8 increases, modified curcumin antioxidant effect decreases.

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Section: Introductionmentioning

confidence: 99%

Synthesis, theoretical analysis, and biological properties of a novel tridentate Schiff base palladium (II) complex

Jahangiry,

Lashanizadegan,

Pourhosseini

et al. 2024

Biometals

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show abstract

“…Curcumin derivatives have antioxidant, anti-diabetic, anti-cancer, anti-allergic, anti coagulant, anti-fungal, and anti-infertility properties [2,5,[21][22][23]. However, the bioavaila bility of this bioactive compound is limited by its low solubility in water [24]. To increase its bioavailability, numerous researchers have tried multiple times and by different meth ods the encapsulation in micro and nano emulsions [25].…”

Section: Introductionmentioning

confidence: 99%

Curcumin: Overview of Extraction Methods, Health Benefits, and Encapsulation and Delivery Using Microemulsions and Nanoemulsions

Ciuca

Racoviţǎ

2023

IJMS

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Curcumin is the principal curcuminoid found in the rhizomes of turmeric. Due to its therapeutic action against cancer, depression, diabetes, some bacteria, and oxidative stress, it has been used widely in medicine since ancient times. Due to its low solubility, the human organism cannot completely absorb it. Advanced extraction technologies, followed by encapsulation in microemulsion and nanoemulsion systems, are currently being used to improve bioavailability. This review discusses the different methods available for curcumin extraction from plant material, methods for the identification of curcumin in the resulting extracts, its beneficial effects on human health, and the encapsulation techniques into small colloidal systems that have been used over the past decade to deliver this compound.

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Paradoxical effects on ice nucleation are intrinsic to a small winter flounder antifreeze protein

Chang,

Sands,

Ewart

2024

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

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Interaction of curcumin with a winter flounder alpha-helical antifreeze protein

Cited by 5 publications

References 27 publications

Synthesis, theoretical analysis, and biological properties of a novel tridentate Schiff base palladium (II) complex

Synthesis, theoretical analysis, and biological properties of a novel tridentate Schiff base palladium (II) complex

Curcumin: Overview of Extraction Methods, Health Benefits, and Encapsulation and Delivery Using Microemulsions and Nanoemulsions

Paradoxical effects on ice nucleation are intrinsic to a small winter flounder antifreeze protein

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