Interaction of Dietary Fat and Soybean Isolate (SBI) on Azaserine-induced Pancreatic Carcinogenesis

Roebuck, Bill D.; Kaplita, Paul V.; MacMillan, Denise L.

doi:10.1007/bf01092201

Cited by 20 publications

(19 citation statements)

References 12 publications

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“…This 48 to 72 hr lag in the response is in agreement with the time required for a trophic response in rats fed RSF (Oates and Morgan, 1984). It has been shown that plasma levels of CCK are raised after trypsin-inhibitor feeding in rats (Roebuck et al, 1987;Loser et al, 1988;Lamers et al, 1989) and mice (Niederau et al, 1986). In the present study, therefore, it is likely that the plasma levels of CCK would be markedly increased after changing to a RSF diet.…”

Section: Ratsupporting

confidence: 63%

Changes in numbers of pancreatic acinar cell nuclei and in DNA content during raw soya flour feeding in mice

Morgan

1990

Am. J. Anat.

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Nuclei of pancreatic cells were isolated by trypsin-detergent digestion of fresh tissue and stained with propidium iodide, and nuclear DNA was measured by flow cytometry. Samples were isolated from mice fed either chow or raw soya flour (RSF) for periods ranging from 1 day to 48 weeks, beginning at 4 weeks of age. In chow-fed mice, the pancreas contained about 80% diploid (2N) and 20% tetraploid (4N) cells at the start of the study, but tetraploidy gradually increased to about 40% 2 weeks later (6 weeks of age) and remained at this level from that time onwards. Low levels of octaploid nuclei (8N) were also present in some animals after 2 weeks. In RSF-fed mice, about 20% tetraploid nuclei were also present for 1 and 2 days after starting RSF, but by 4 days tetraploidy had increased significantly to 40% and by 14 days had further increased to 50%. This level was significantly higher than that seen in chow-fed animals and was maintained for up to 48 weeks. Significantly higher numbers of octaploid nuclei were also present in the RSF-fed animals. In both chow- and RSF-fed mice, most cells were mononuclear, averaging 70% in chow-fed and 64% in RSF-fed animals. This difference was significant. This study shows that the mouse pancreas differs from the rat pancreas in the absence of a large population of binucleate acinar cells and the presence of considerable nuclear tetraploidy. Raw soya flour feeding leads to significant changes in these features, but in this species these changes do not appear to predispose to neoplasia.

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Section: Ratsupporting

confidence: 63%

Changes in numbers of pancreatic acinar cell nuclei and in DNA content during raw soya flour feeding in mice

Morgan

1990

Am. J. Anat.

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“…Several studies have investigated the suitability of different vegetable oils for the human diet, reporting on reductions in genotoxicity and/or cancer potentiation by sesame oil [Salerno and Smith, 1991], sunflower oil [Cognault et al, 2000], perilla and palm oil [Nakayama et al, 1993], olive, sunflower, peanut, corn, and soy oils [La Vecchia et al, 1995], flax seed oil [Rao et al, 2000], and coconut oil [Burns et al, 1978], among others. Some negative effects were also reported for these oils, including data indicating increases in genotoxicity/ carcinogenesis modulated by sunflower oil [Burns et al, 1978;Hopkins et al, 1978;Reeve et al, 1996], olive oil [Brennan-Craddock et al, 1990], corn oil [Roebuck et al, 1987], and soy oil [Miwa et al, 1996;Zhou et al, 2000].…”

Section: Introductionmentioning

confidence: 92%

Genotoxicity of vegetable cooking oils in the Drosophila wing spot test

Rojas-Molina

Campos-Sánchez

Analla

et al. 2004

Environ. Mol. Mutagen.

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Seven vegetable oils consumed by humans were tested for genotoxic activity in the Drosophila somatic mutation and recombination test. The oils included five seed oils (sesame, sunflower, wheat germ, flax, and soy oil) and both first-class extra-virgin and low-grade (refined) olive oil. Larvae of the standard (STD) and highly bioactive (NORR) crosses of Drosophila melanogaster were fed medium containing 6% and 12% of each of the oils. Flax oil produced the strongest response, while sesame, wheat germ, and soy oil showed some genotoxic activity. Sunflower and the low-grade olive oil gave inconclusive results, and extra-virgin olive oil was clearly nongenotoxic. It is argued that the genotoxicity is probably due to the fatty acid composition of the oils, which after peroxidation can form specific DNA-adducts.

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“…Animal research has suggested dietary factors, i.e. intake of energy and of the energy-providing nutrients fat and protein, as likely contributory causes in pancreatic cancer induced by nitrosamines (hamsters) (Birt et al, 1981) or azaserine (rats) (Roebuck et al, 1981). Several epidemiologic studies have focused on the relationship between diet and pancreatic cancer.…”

Section: 51-718) No Indication Of An Effect Of Quetelet Index Wasmentioning

confidence: 98%

“…Animal experiments support this view, as corn oil, fish oil, raw soy bean protein and casein were shown to influence pancreatic carcinogenesis in rats and hamsters (Birt etal., 1981;O'Connor et al, 1985;Roebuck et al, 1987;.…”

Section: 51-718) No Indication Of An Effect Of Quetelet Index Wasmentioning

confidence: 99%

Are energy and energy‐providing nutrients related to exocrine carcinoma of the pancreas?

Mesquita

Moerman

Runia

et al. 1990

Intl Journal of Cancer

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During 1984-88 a population-based case-control study was carried out in The Netherlands in collaboration with the International Agency for Research on Cancer in order to further explore the possible relationship between diet and exocrine pancreatic carcinoma. Past habitual dietary intake was assessed in 164 cases and 480 controls. This is the first series of population-based studies of pancreas cancer to perform a comprehensive assessment of diet. The results of logistic regression analysis, controlled for age, gender and total cigarette consumption, suggested a positive association with past habitual intake of energy in directly interviewed patients (OR highest versus lowest quintile 3.35; 95% confidence interval 1.51-7.18). No indication of an effect of Quetelet index was found. When maximum-weight-ever-achieved was used, nonsignificantly reduced risks were observed for the upper 4 quintiles of "maximum" Quetelet index. After controlling for age, gender, response status and total cigarette consumption, a positive relationship with habitual past intake of total carbohydrates was observed (OR 2.40; 95% confidence interval 1.44-3.99). The effect decreased considerably when the analysis was restricted to subjects who reported stable long-term dietary intake. After controlling for age, gender, total cigarette consumption and response status, a significant, positive association between pancreatic cancer and past habitual intake of simple sugars was found (OR 1.95; 95% confidence interval 1.24-3.07). Among those who reported stable long-term dietary intake, no effect was seen. The positive effect of simple sugars was present in males only (OR 2.15; 95% confidence interval 1.18-3.93) and was smaller in men who reported long-term stable dietary intake. Our findings suggest that the development of exocrine pancreatic carcinoma is positively related to past habitual intake of total energy, total carbohydrates and simple sugars, whereas no relationship with body-mass index was observed.

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Interaction of Dietary Fat and Soybean Isolate (SBI) on Azaserine-induced Pancreatic Carcinogenesis

Cited by 20 publications

References 12 publications

Changes in numbers of pancreatic acinar cell nuclei and in DNA content during raw soya flour feeding in mice

Changes in numbers of pancreatic acinar cell nuclei and in DNA content during raw soya flour feeding in mice

Genotoxicity of vegetable cooking oils in the Drosophila wing spot test

Are energy and energy‐providing nutrients related to exocrine carcinoma of the pancreas?

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