Interaction of dietary resveratrol with animal-associated bacteria

Jung, Carina M.; Heinze, Thomas M.; Schnackenberg, Laura K.; Mullis, Lisa B.; Elkins, Stephanie A.; Elkins, Christopher A.; Steele, Roger; Sutherland, John B.

doi:10.1111/j.1574-6968.2009.01691.x

Cited by 72 publications

(46 citation statements)

References 38 publications

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“…1993), Nocardioides luteus BAFB (Jung et al. 2002), Propionibacteria acnes ATCC 6919 , Proteus mirabilis ATCC 7002, Pseudomonas aeruginosa (Jung et al. 2009) , Ps.…”

Section: Methodsmentioning

confidence: 99%

Horizontal gene transfer (HGT) as a mechanism of disseminating RDX-degrading activity among Actinomycete bacteria

Jung

Crocker

Eberly

et al. 2011

Journal of Applied Microbiology

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Aims: Hexahydro‐1,3,5‐trinitro‐1,3,5,‐triazine (RDX) is a cyclic nitramine explosive that is a major component in many high‐explosive formulations and has been found as a contaminant of soil and groundwater. The RDX‐degrading gene locus xplAB, located on pGKT2 in Gordonia sp. KTR9, is highly conserved among isolates from disparate geographical locations suggesting a horizontal gene transfer (HGT) event. It was our goal to determine whether Gordonia sp. KTR9 is capable of transferring pGKT2 and the associated RDX degradation ability to other bacteria. Methods and Results: We demonstrate the successful conjugal transfer of pGKT2 from Gordonia sp. KTR9 to Gordonia polyisoprenivorans, Rhodococcus jostii RHA1 and Nocardia sp. TW2. Through growth and RDX degradation studies, it was demonstrated that pGKT2 conferred to transconjugants the ability to degrade and utilize RDX as a nitrogen source. The inhibitory effect of exogenous inorganic nitrogen sources on RDX degradation in transconjugant strains was found to be strain specific. Conclusions: Plasmid pGKT2 can be transferred by conjugation, along with the ability to degrade RDX, to related bacteria, providing evidence of at least one mechanism for the dissemination and persistence of xplAB in the environment. Significance and Impact of Study: These results provide evidence of one mechanism for the environmental dissemination of xplAB and provide a framework for future field relevant bioremediation practices.

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“…1993), Nocardioides luteus BAFB (Jung et al. 2002), Propionibacteria acnes ATCC 6919 , Proteus mirabilis ATCC 7002, Pseudomonas aeruginosa (Jung et al. 2009) , Ps.…”

Section: Methodsmentioning

confidence: 99%

Horizontal gene transfer (HGT) as a mechanism of disseminating RDX-degrading activity among Actinomycete bacteria

Jung

Crocker

Eberly

et al. 2011

Journal of Applied Microbiology

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“…Third, they most likely were derived from intestinal bacterial metabolism. Dihydroresveratrol was later also identified in rat urine, 20 plasma, 21 and, most importantly, from incubates of resveratrol with mammalian fecal bacterial species 22 . Dihydroresveratrol's biological activity is still incompletely understood but may be less than for resveratrol 23 .…”

Section: Reduced Metabolic Productsmentioning

confidence: 99%

Bioavailability of resveratrol

Walle

2011

Annals of the New York Academy of Sciences

793

555

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This paper reviews our current understanding of the absorption, bioavailability, and metabolism of resveratrol, with an emphasis on humans. The oral absorption of resveratrol in humans is about 75% and is thought to occur mainly by transepithelial diffusion. Extensive metabolism in the intestine and liver results in an oral bioavailability considerably less than 1%. Dose escalation and repeated dose administration of resveratrol does not appear to alter this significantly. Metabolic studies, both in plasma and in urine, have revealed major metabolites to be glucuronides and sulfates of resveratrol. However, reduced dihydroresveratrol conjugates, in addition to highly polar unknown products, may account for as much as 50% of an oral resveratrol dose. Although major sites of metabolism include the intestine and liver (as expected), colonic bacterial metabolism may be more important than previously thought. Deconjugation enzymes such as β-glucuronidase and sulfatase, as well as specific tissue accumulation of resveratrol, may enhance resveratrol efficacy at target sites. Resveratrol analogs, such as methylated derivatives with improved bioavailability, may be important in future research.

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“…This was probably due to the fact that both bacterial groups could be inhibited by phenolic compounds including gallic acid and resveratrol metabolites in in vitro studies. [44][45][46] In addition, Enterococcus genus bacteria have been inhibited by cloudberry intake. 47 Although we found signicant inverse associations between Eggerthella lenta and Enterococcus tertiles and some phenolic acid concentrations, changes in Eggerthella lenta and Enterococcus cannot be predicted by phenolic acids changes.…”

Section: 43mentioning

confidence: 99%

High levels of Bifidobacteria are associated with increased levels of anthocyanin microbial metabolites: a randomized clinical trial

et al. 2014

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The health benefits associated with the consumption of polyphenol-rich foods have been studied in depth, however, the full mechanism of action remains unknown. One of the proposed mechanisms is through microbiota interaction. In the present study, we aimed to explore the relationship between changes in fecal microbiota and changes in urinary phenolic metabolites after wine interventions. Nine participants followed a randomized, crossover, controlled interventional trial. After the washout period, they received red wine, dealcoholized red wine or gin for 20 days each. Polyphenol metabolites (n > 60) in urine were identified and quantified by UPLC-MS/MS and the microbial content of fecal samples was quantified by real-time quantitative PCR. Interventions with both red wine and dealcoholized red wine increased the fecal concentration of Bifidobacterium, Enterococcus and Eggerthella lenta, compared to gin intervention and baseline. When participants were categorized in tertiles of changes in fecal bacteria, those in the highest tertile of Bifidobacteria had higher urinary concentration changes in syringic acid, pcoumaric acid, 4-hydroxybenzoic acid and homovanillic acid (all anthocyanin metabolites) than those in tertile 1 (P < 0.05, all). In addition, changes of Bifidobacteria correlated positively with changes of these metabolites (r ¼ 0.5-0.7, P < 0.05, all). Finally, the 68.5% changes in Bifidobacteria can be predicted by syringic acid and 4-hydroxybenzoic acid changes. This study confirms the important role of polyphenols as bacterial substrates and their modulatory capacity as an important field in the research of new products with prebiotic and probiotic characteristics for the food industry.

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Interaction of dietary resveratrol with animal-associated bacteria

Cited by 72 publications

References 38 publications

Horizontal gene transfer (HGT) as a mechanism of disseminating RDX-degrading activity among Actinomycete bacteria

Horizontal gene transfer (HGT) as a mechanism of disseminating RDX-degrading activity among Actinomycete bacteria

Bioavailability of resveratrol

High levels of Bifidobacteria are associated with increased levels of anthocyanin microbial metabolites: a randomized clinical trial

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