Interaction of doxorubicin delivered by superparamagnetic iron oxide nanoparticles with DNA

Dukhopelnykov, E. V.; Blyzniuk, Yu.N.; Skuratovska, Anastasiia; Bereznyak, E. G.; Gladkovskaya, N. A.

doi:10.1016/j.colsurfb.2022.112815

Cited by 8 publications

(4 citation statements)

References 40 publications

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“…Doxorubicin (DOX) is an antineoplastic antibiotic with wide pharmacological activity [ 2 , 3 , 7 , 24 , 31 , 34 , 35 , 36 , 37 , 38 ]. Analysis of DOX levels is an important task for the determination of this medication in body fluids for the individualization of drug dosage, and for the investigation and evaluation of the mechanism of drug–biomolecule(s) interactions [ 12 , 39 , 40 , 41 ].…”

Section: Resultsmentioning

confidence: 99%

“…For the investigation of DNA–drug interaction, a complex of DNA with DOX was formed at specified concentrations of pharmaceutical formulations and constant concentration of DNA at 1.5 mg/mL, and was incubated 10 min before adsorption onto the electrode surface [ 21 , 35 , 36 ]. Differential pulse voltammetry (DPV) was carried out in the potential range of 0.2–1.2 V, potential step 0.005 V, pulse amplitude 0.025 V, pulse duration 0.05 s, scanning frequency 0.05 s.…”

Section: Methodsmentioning

confidence: 99%

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Interaction of Doxorubicin Embedded into Phospholipid Nanoparticles and Targeted Peptide-Modified Phospholipid Nanoparticles with DNA

et al. 2023

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The interactions of dsDNA with new targeted drug delivery derivatives of doxorubicin (DOX), such as DOX embedded into phospholipid nanoparticles (NPhs) and DOX with the NGR targeted peptide-modified NPhs were studied electrochemically by differential pulse voltammetry technique. Screen-printed electrodes (SPEs), modified with stable fine dispersions of carbon nanotubes (CNTs), were used for quantitative electrochemical investigations of direct electrochemical oxidation of guanine, adenine, and thymine heterocyclic bases of dsDNA, and their changes in the presence of DOX nanoderivatives. Analysing the shifts of peak potentials of nucleobases in the presence of drug, we have shown that the doxorubicin with NGR targeted peptide changed the mode of interaction in DNA–drug complexes from intercalative to electrostatic. Binding constants (Kb) of DNA–drug complexes were calculated in accordance with adenine, guanine, and thymine oxidation signals. Based on our experiments, we have proven that the surface modification of a drug delivery system with NGR targeted peptide dramatically changed the mechanism of interaction of drug with genetic material. DNA-mediated drug toxicity was calculated based on the concentration-dependent “response” of heterocyclic nucleobases on drug influence. DOX, DOX-loaded phospholipid nanoparticles (NPhs), and DOX with NGR addressed peptide-modified NPhs were moderately toxic in the concentration range of 0.5–290 µM.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Interaction of Doxorubicin Embedded into Phospholipid Nanoparticles and Targeted Peptide-Modified Phospholipid Nanoparticles with DNA

et al. 2023

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“…The route of entry into cancer cells is primarily determined by the material of the nanoparticle. Currently, the following nanoforms are used as nanoscale carriers for drugs ( Figure 5 ): Biological and biogenic nanoparticles (enzymes, proteins, ribosomes, and viruses) [ 47 , 48 , 49 ]; Polymer nanoparticles and nanostructures (polymer nanoparticles, polymer nanocapsules, polymer micelles, and dendrimers [ 50 , 51 , 52 ]; Liposomes [ 53 ]; Perfluorocarbon nanoparticles [ 54 , 55 ]; Carbon nanoparticles (nanotubes, fullerenes, graphene, and nanodiamonds) [ 56 , 57 , 58 ]; Inorganic nanoparticles (metals such as gold, silver, platinum, titanium, zinc, and iron; metal and nonmetal oxides; and magnetic nanoparticles) [ 59 , 60 , 61 , 62 , 63 ]; Quantum dots and semiconductor nanocrystals [ 64 , 65 ]. …”

Section: Application Of Micro- and Nanoparticles In Drug Delivery Sys...mentioning

confidence: 99%

“…Inorganic nanoparticles (metals such as gold, silver, platinum, titanium, zinc, and iron; metal and nonmetal oxides; and magnetic nanoparticles) [ 59 , 60 , 61 , 62 , 63 ];…”

Section: Application Of Micro- and Nanoparticles In Drug Delivery Sys...mentioning

confidence: 99%

Surface Modification of Mesoporous Silica Nanoparticles for Application in Targeted Delivery Systems of Antitumour Drugs

Kovtareva,

Kusepova,

Tazhkenova

et al. 2024

Polymers

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The problem of tumour therapy has attracted the attention of many researchers for many decades. One of the promising strategies for the development of new dosage forms to improve oncology treatment efficacy and minimise side effects is the development of nanoparticle-based targeted transport systems for anticancer drugs. Among inorganic nanoparticles, mesoporous silica deserves special attention due to its outstanding surface properties and drug-loading capability. This review analyses the various factors affecting the cytotoxicity, cellular uptake, and biocompatibility of mesoporous silica nanoparticles (MSNs), constituting a key aspect in the development of safe and effective drug delivery systems. Special attention is paid to technological approaches to chemically modifying MSNs to alter their surface properties. The stimuli that regulate drug release from nanoparticles are also discussed, contributing to the effective control of the delivery process in the body. The findings emphasise the importance of modifying MSNs with different surface functional groups, bio-recognisable molecules, and polymers for their potential use in anticancer drug delivery systems.

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Nano–bio interactions: understanding their dynamic connections

Habeeb,

Vengateswaran,

Kumbhar

et al. 2025

Theranostics Nanomaterials in Drug Delivery

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Interaction of doxorubicin delivered by superparamagnetic iron oxide nanoparticles with DNA

Cited by 8 publications

References 40 publications

Interaction of Doxorubicin Embedded into Phospholipid Nanoparticles and Targeted Peptide-Modified Phospholipid Nanoparticles with DNA

Interaction of Doxorubicin Embedded into Phospholipid Nanoparticles and Targeted Peptide-Modified Phospholipid Nanoparticles with DNA

Surface Modification of Mesoporous Silica Nanoparticles for Application in Targeted Delivery Systems of Antitumour Drugs

Nano–bio interactions: understanding their dynamic connections

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