Interaction of drug based binuclear mixed-ligand complexes with DNA

Patel, Mohan N.; Chhasatia, M. R.; Gandhi, Deepen S.

doi:10.1016/j.bmc.2009.06.023

Cited by 25 publications

(10 citation statements)

References 39 publications

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“…Obtaining the most accurate chemical structure of silver complexes is closely related to its biological properties, such as the identification of pharmacophores, 82 interaction with DNA and antibacterial activity, 83 , 84 blocking of topoisomerase II enzymes (inhibiting the DNA repair activity) and possible anti-cancer, anti-fungal and anti-parasitic effects. 2 , 4 , 18 …”

Section: Discussionmentioning

confidence: 99%

Essential Guide of Analysis Methods Applied to Silver Complexes with Antibacterial Quinolones

Rusu¹,

Hancu²,

Imre³

2018

Adv Pharm Bull

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To describe the chemical structure and characterize physico-chemical properties of organometallic complexes it is necessary to use a complex set of analysis methods. Thus, this review has been compiled as a relevant guide which includes the most commonly used methods of analysis in the study of silver complexes with antibacterial quinolones, compounds with promising biological potential. This selection of analysis methods puts on balance the obtained data and the accessibility of the experimental approach. The steps to follow in order to obtain reliable structural information about organometallic complexes of silver, particularly the silver complexes of antibacterial quinolones, are established and presented in the review.

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Section: Discussionmentioning

confidence: 99%

Essential Guide of Analysis Methods Applied to Silver Complexes with Antibacterial Quinolones

Rusu¹,

Hancu²,

Imre³

2018

Adv Pharm Bull

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“…From this perspective, the synthesis of new metal complexes and evaluation of their antibacterial activity have been considered by the global community as part of the solution (Saha et al, 2009;Rafique et al, 2010). Based on this, a good number of mononuclear (Ghatole et al, 2012;Pasdar et al, 2015;Atakilt Abebe and Tizazu Hailemariam, 2016;Atakilt Abebe and Getinet Tamiru, 2018), binuclear (Patel et al, 2009;Krishna et al, 2013;Gurumoorthy et al, 2014;Panda et al, 2015;) and metal mixed-ligand complexes have been reported in the literature. In particular, Co (II) containing mixed ligand complexes appeared promising in solving the aforementioned problems (Patel et al, 2009;Chang et al, 2010).…”

Section: Introductionmentioning

confidence: 92%

“…Based on this, a good number of mononuclear (Ghatole et al, 2012;Pasdar et al, 2015;Atakilt Abebe and Tizazu Hailemariam, 2016;Atakilt Abebe and Getinet Tamiru, 2018), binuclear (Patel et al, 2009;Krishna et al, 2013;Gurumoorthy et al, 2014;Panda et al, 2015;) and metal mixed-ligand complexes have been reported in the literature. In particular, Co (II) containing mixed ligand complexes appeared promising in solving the aforementioned problems (Patel et al, 2009;Chang et al, 2010). In most of these reports, however, Co (II) complexes did not work against Gramnegative bacteria (Shalash and Ali, 2017).…”

Section: Introductionmentioning

confidence: 92%

Synthesis, structural investigation and biological application of new mono- and binuclear cobalt (II) mixed-ligand complexes containing 1,10-phenanthroline, acetamide and ethylenediamine

Tamiru¹,

Abebe²,

Abebe³

et al. 2019

Eth J Sci & Technol

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The intensive use of antibiotics has led to an increase of drug resistant bacteria against known antibiotics. To overcome the alarming problem of microbial resistance to antibiotics, the discovery of novel active compounds against new targets is a matter of urgency. Based on this, we report three new mixed ligand complexes of cobalt (II)viz. mononuclear ([Co(phen)2(Act)(H2O)]Cl2.H2O and [Co(phen)2(Act)(en)]Cl2), and binuclear [Co2(phen)4(Act)2(en)]Cl4 which were synthesized from CoCl2.6H2O, 1,10-phenanthroline monohydrate, acetamide and ethylenediamine. These complexes were characterized using spectroscopic (ESI-MS, ICP-OES, FT-IR, and UV-Vis), chloride determination as well as melting point and conductance measurement. Invitro antibacterial activity was also tested on two Gram positive (Staphylococcus aureus, Streptococcus pyogenes) and two Gram negative (Escherichia coli and Klebsiella pneumoniae) bacteria using disc diffusion method. The complexes performed well even against the Gram-negative bacteria. The antibacterial result was found comparable with the commercial drug Gentamicin even at lower concentration of complexes. Thus, the synthesized complexes may be considered as potential antibacterial agents after passing cytotoxicity testing.

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“…All the ligands N,N 0 -bis-(4-methoxy-phenyl)-1,2-dimethylethane-1,2-diimine (L 2 ), N,N 0 -bis-(4-methoxy-benzylidene)-ethane-1,2-diamine (L 3 ), N,N 0 -dicyclohexylidene-benzene-1,2-diamine (L 4 ), N,N 0 -bis-(4-methoxy-benzylidene)-benzene-1,2-diamine (L 5 ), N,N 0 -bis-(3-chlorophenyl)-1,2-diphenylethane-1,2-diimine (L 6 ), bis(benzylidene)ethylenediamine (L 7 ), N,N 0 -bis-(4-methoxyphenyl)-1,2-diphenylethane-1, 2-diimine (L 8 ), N,N 0 -bis-(phenyl)-1,2-dimethyl-ethane-1, 2-diimine (L 9 ), 4-methoxy-N-(thiophene-2-ylmethylene) aniline (L 10 ), 3-amino-2-phenyl-3H-quinazolin-4-one (L 11 ), N,N 0 -bis-(1-phenyl-ethylidene)-ethane-1,2-diamine (L 12 ), N,N 0 -dicyclohexylidene-napthalene-1,8-diamine (L 13 ), N,N 0 -(1, 2-diphenyl-ethane-1,2-diylidene)dianiline (L 14 ), N,N 0 -bis-(1-phenyl-ethylidene)-benzene-1,2-diamine (L 15 ) were prepared according to the literature Patel, 2007, 2008a, b;Patel et al, 2009b) except di-pyridin-2-ylamine (L 1 ), ethylenediamine (L 16 ), o-phenylenediamine (L 17 ) and 1,8-aminonaphathalene (L 18 ) which were used as such. The structures and the physicochemical parameters are represented in Fig.…”

Section: Synthesis Of Ligandsmentioning

confidence: 99%

DNA binding and cleavage by dinuclear nickel(II) complexes with neutral bidentate ligands and ciprofloxacin

Patel

Pansuriya

2010

Med Chem Res

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Dinuclear nickel(II) complexes of type [Ni 2 (L) 2 (cpf) 2 (H 2 O) 2 ]Á2H 2 O have been synthesized and characterized using spectral, physicochemical, mass spectra and elemental analyses. Antimicrobial efficacy of the compounds has been screened against five different microorganisms. Interestingly, all complexes demonstrated potent in-vitro antibacterial activity against gram-positive Staphylococcus aureus, Bacillus subtilis, and gram-negative Pseudomonas aeruginosa, Serratia marcescens, and Escherichia coli bacteria. Moreover, the interactions of the prepared complexes with DNA helix were studied using absorption titrations, gel electrophoresis, and viscometric techniques.

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Interaction of drug based binuclear mixed-ligand complexes with DNA

Cited by 25 publications

References 39 publications

Essential Guide of Analysis Methods Applied to Silver Complexes with Antibacterial Quinolones

Essential Guide of Analysis Methods Applied to Silver Complexes with Antibacterial Quinolones

Synthesis, structural investigation and biological application of new mono- and binuclear cobalt (II) mixed-ligand complexes containing 1,10-phenanthroline, acetamide and ethylenediamine

DNA binding and cleavage by dinuclear nickel(II) complexes with neutral bidentate ligands and ciprofloxacin

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