Interaction of exercise and ethanol on antioxidant enzymes in brain regions of the rat

Somani, Satu M.; Husain, Kazim; Diaz-Phillips, L.; Lanzotti, D.; Kareti, K. R.; Trammell, Gary L.

doi:10.1016/s0741-8329(96)00075-4

Cited by 81 publications

(40 citation statements)

References 26 publications

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“…16) The GPx enzyme works in tandem with CAT to scavenge excess H 2 O 2 and lipid peroxides in response to oxidative stress. 14,17,18) However, unlike CAT activity, GPx activity depends on the balance between the levels of glutathione and glutathione disulfide. 19) The difference between the responses of GPx and CAT to ethanol treatment in Aldh2 -/-mice may be due to differences in precursors, including hepatic glutathione contents.…”

Section: Resultsmentioning

confidence: 99%

Activities of Antioxidant Enzymes Induced by Ethanol Exposure in Aldehyde Dehydrogenase 2 Knockout Mice

Eom

Zhang

Ogawa

et al. 2007

JOURNAL OF HEALTH SCIENCE

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Acetaldehyde production during ethanol metabolism has been implicated as an important link between oxidative stress and cell damage, which suggests that oxidative stress caused by ethanol exposure may be more severe in aldehyde dehydrogenase 2 (ALDH2)-deficient individuals than in those with wild-type ALDH2. We evaluated the activities of the major antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), in liver tissue isolated from Aldh2 +/+ and Aldh2 -/-mice that were exposed to ethanol. The activities of CAT and GPx were significantly increased by ethanol treatment in Aldh2 +/+ mice (3.33-fold and 1.65-fold, respectively). The mean activity of SOD in Aldh2 +/+ mice was 1.46-fold that in the Aldh2 +/+ control group, but the difference was not statistically significant. In Aldh2 -/-mice, the activities of SOD and CAT were decreased and that of GPx was slightly increased after ethanol exposure, but the differences were not significant. We postulate that antioxidant enzyme expression after ethanol consumption may differ according to the intracellular level of acetaldehyde or free radicals, which in turn depends on the activity of ALDH2. These results suggest that the greater toxicity of ethanol in Aldh2 -/-mice than in Aldh2 +/+ mice may be due to decreased antioxidant enzyme expression.

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Section: Resultsmentioning

confidence: 99%

Activities of Antioxidant Enzymes Induced by Ethanol Exposure in Aldehyde Dehydrogenase 2 Knockout Mice

Eom

Zhang

Ogawa

et al. 2007

JOURNAL OF HEALTH SCIENCE

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“…Macrophages are also activated by superoxides in vivo, the generation of which include inflammation and cellular stress. Somali et al [7] demonstrated the interaction of exercise and alcohol on antioxidant enzymes in brain regions of the rat in 1996. Macrophages operate as a common final pathway for immunological and inflammatory waste management.…”

Section: Open Accessmentioning

confidence: 99%

RETRACTED ARTICLE: Purified umbilical cord derived mesenchymal stem cell treatment in a case of systemic lupus erythematosus

Phillips¹,

Wongsaisri²,

Htut³

et al. 2017

Clinical & Translational Med

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“…In fact, this kind of exercise generates high levels of reactive oxygen species, leading to oxidative damage of important macromolecules (Aguiló et al 2005). Although moderate exercise causes adaptation of brain antioxidant and repair systems by increasing its resistance to oxidative stress (Radák et al 2001;Somani and Husain 1997), acute and IE seems to enhance its lipid peroxidation (Hara et al 1997;Somani et al 1996). However, the effects of IE on either oxidative damage or antioxidant status of the brain are still conflicting, and some authors did not observe exerciseinduced alterations in the brain lipid peroxidation or in the antioxidant enzymes activities (Acikgoz et al 2006;Ö zkaya et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress Induced by Intense and Exhaustive Exercise Impairs Murine Cognitive Function

Rosa¹,

Takahashi²,

Aboulafia³

et al. 2007

Journal of Neurophysiology

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Rosa EF, Takahashi S, Aboulafia J, Nouailhetas VL, Oliveira MG. Oxidative stress induced by intense and exhaustive exercise impairs murine cognitive function. J Neurophysiol 98: 1820 -1826, 2007. First published July 11, 2007 doi:10.1152/jn.01158.2006. It has been shown that exercise is helpful against brain disorders. However, this may not be true for intense exercise (IE). Because it is easy to misadjust exercise intensity with physical condition, it is essential to know the effects of IE on cognitive process because it may have important consequences on people skills and work skills. We investigated the effects of IE on male C57Bl/6 mice, 3-mo-old, undergoing 10 days of intense and exhaustive running program on cognition and its possible relationship with brain oxidative stress. Cognition was evaluated by three different cognitive tests: passive avoidance task, contextual fear conditioning, and tone fear conditioning, performed 24 h after the last exercise session. Brain oxidative stress was evaluated by lipid peroxidation and protein oxidation. There was a remarkable memory reduction of exercised animals in comparison with the control group, associated with increase in the brain oxidative stress, with no alterations in shock sensitivity, locomotion and anxiety parameters. Concurrent vitamin C and E supplementation fully prevented the memory decrement induced by IE and partially recovered both the increased the brain lipid peroxidation and the protein oxidation. In conclusion, IE-induces a high index of brain oxidative stress and impairs memory in murine model that was prevented by vitamin C and E supplementation.

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Interaction of exercise and ethanol on antioxidant enzymes in brain regions of the rat

Cited by 81 publications

References 26 publications

Activities of Antioxidant Enzymes Induced by Ethanol Exposure in Aldehyde Dehydrogenase 2 Knockout Mice

Activities of Antioxidant Enzymes Induced by Ethanol Exposure in Aldehyde Dehydrogenase 2 Knockout Mice

RETRACTED ARTICLE: Purified umbilical cord derived mesenchymal stem cell treatment in a case of systemic lupus erythematosus

Oxidative Stress Induced by Intense and Exhaustive Exercise Impairs Murine Cognitive Function

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