Interaction of gelatin with promethazine hydrochloride: Conductimetry, tensiometry and circular dichroism studies

2016

J. Phys. Org. Chem.

Self Cite

121

Micellization (aggregation) phenomenon of amphiphilic phenothiazine drug promazine hydrochloride (PMZ) and sodium dodecylbenzenesulfonate (SDBS) mixtures in absence and attendance of 50 mmol•kg À1 NaCl (salt)/300 mmol•kg À1 urea was investigated conductometrically at five various temperatures (293.15-318.15 K) at gaps of T = 5 K. PMZ is employed for the cure of mania and schizophrenia. The critical micelle concentration (CMC) values have been evaluated and defined in terms of hydrophobicity and hydrophilicity of PMZ and SDBS in aqueous and nonaqueous solutions. With increasing the temperature, the CMC first increases then decreases. At 303.15 K, the maximum CMC values were obtained in absence and presence of NaCl/urea. NaCl reduces the CMC of pure amphiphiles and their mixtures while urea increases. Various physicochemical parameters such as CMC id (ideal critical micelle concentration), micellar mole fraction of SDBS (X 1 ) (calculated by different proposed models), and interaction parameter have been evaluated and discussed in detail. The values of degree of dissociation (g) and CMC of the micelles were utilized to evaluate the different thermodynamic parameters. Activity coefficients (f 1 and f 2 ) and excess free energy of micellization (ΔG ex ) values were also evaluated. All outcomes obtained herein show attractive interactions in the mixtures of PMZ and SDBS.

Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Aggregation behavior of amphiphilic drug promazine hydrochloride and sodium dodecylbenzenesulfonate mixtures under the influence of NaCl/urea at various concentration and temperatures

Kumar

2016

J. Phys. Org. Chem.

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121

“…The nonideality in mixed micelles of PMZ-aniline hydrochloride mixtures in absence and presence of 50 mmol kg −1 NaCl can be evaluated by using the regular solution theory (RST), given by Rubingh based on the phase separation model of micellization [44]. The elementary equation is (2) where X 1 Rub is the micellar mole fraction of aniline hydrochloride in the mixture and CMC 1 and CMC 2 are the CMC values of the pure aniline hydrochloride and PMZ, respectively. The equation was solved iteratively to obtain the value of X 1…”

Section: Composition and Interaction Of Mixed Micelles In Absence Andmentioning

confidence: 99%

“…Amphiphilic molecules such as surfactants, drugs, hydrotropes, and polymers self-associate in aqueous solution to form micelles or related structures above a certain concentration known as critical micelle concentration (CMC) [1][2][3][4][5][6][7]. These micelles are of widespread use in pharmaceutical applications besides food, detergency, cosmetic industries and enhanced oil recovery and range of applications [8].…”

Section: Introductionmentioning

confidence: 99%

Micellization behavior of mixtures of amphiphilic promazine hydrochloride and cationic aniline hydrochloride in aqueous and electrolyte solutions

Azum

Khan

et al. 2015

Korean J. Chem. Eng.

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We studied the influence of cationic hydrotrope aniline hydrochloride on the micellization behavior of cationic amphiphilic phenothiazine drug promazine hydrochloride in the presence and absence of 50 mmol kg −1 NaCl. The experimental critical micelle concentration (CMC) values came out to be lower than ideal CMC (CMC id ) values, signifying attractive interactions between the two components in mixed micelles. NaCl further decreases the CMC of pure PMZ and aniline hydrochloride as well as their mixture due to screening of the electrostatic repulsion among the polar head groups. The bulk properties of solution were examined by using different theoretical models for justification and comparison of results. The micellar mole fraction of aniline hydrochloride (X 1 Rub , X 1 M , X 1Rod and X 1 id ) was evaluated by different proposed models, showing greater contribution of hydrotrope in mixed micelle. The negative values of interaction parameter (β) indicate synergistic interactions and negative values of β further decrease by the addition of salt in mixed systems. From the CMC values as a function of temperature, various thermodynamic properties have been evaluated and discussed in detail.

“…[11] Here, we used conductometric measurements to determine the CMC of drug-anionic surfactant (sodium bis (2-ethylhexyl)sulfosuccinate (AOT)) binary systems toward the detailed characterization of physicochemical properties of drug=anionic surfactants systems. There are several reports on the micellization and clouding behavior of amphiphilic drugs that have been published by our groups earlier [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] with most of them being either cationiccationic or cationic-nonionic interactions; however, in the second paper by our group, we have reported the cationic drug (PMT)-anionic surfactant (AOT) interactions at different temperatures and compositions. The tendency of the drug and AOT to form mixed micelles in aqueous form is governed by their synergistic or repulsive interactions and is often explained by the interaction parameter estimated using Rubingh's regular solution theory.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Properties of Amphiphilic Drug and Anionic Surfactant Mixtures: Experimental and Theoretical Approach

Journal of Dispersion Science and Technology

Azum

Khan

et al. 2014

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Herein, we have reported the mixed micelle formation of amphiphilic phenothiazine drug promethazine hydrochloride (PMT) and anionic surfactant sodium bis(2-ethylhexyl)sulfosuccinate (AOT) mixtures at different compositions and temperatures (288.15, 293.15, 298.15, 303.15, and 308.15 K). A conductometric method is used to evaluate the critical micelle concentration (CMC) of binary mixtures. An attractive interaction between PMT and AOT mixed systems was indicated by the experimental and ideal critical micelle concentration (CMC and CMC id ) values. The micellar mole fraction of anionic surfactant (X Rub 1 , X M 1 , X Rod 1 , and X id 1 ) was evaluated by different proposed models, and they prove the greater contribution of AOT in mixed micelle and increase with the increase in AOT concentration. Activity coefficients (f 1 and f 2 ) calculated by all recommended models were found to be always less than unity, signifying nonideality in the mixed systems. Different thermodynamic parameters have also been evaluated using the respective CMC values as a function of temperature. DG m values were always found to be negative for all the systems; however, DH m for pure drug as well as PMT-AOT mixed systems is negative at lower temperatures and positive at higher temperatures. The DS m values are positive at all temperatures but their magnitude is higher at T ¼ 303.15 K and above.