Interaction of genotype and exogenous neonatal estrogen: Aggression in female mice

Vale, Jack R.; Ray, Donald; Vale, Carol A.

doi:10.1016/0031-9384(73)90294-1

Cited by 14 publications

(9 citation statements)

References 9 publications

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“…This strain relationship was identical for intact males under the same test conditions. Similar results were found for females of the same strains when given neonatal estrogen (Vale et al, 1973).…”

Section: Sex Hormonessupporting

confidence: 84%

Selection for agonistic behavior in wild femaleMus musculus

Ebert

Hyde

1976

Behav Genet

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Artificial selection was used to establish different levels of agonistic behavior in laboratory-reared wild female Mus musculus. A within-family selection design with replicated high and low lines and two nonselected control lines was employed. Females only were tested at 8 weeks of age on 2 consecutive days. Testing consisted of placing a C57BL/6 female mouse in the home cage of the isolation-reared wild mouse for 7 min or until an attack occurred. The wild females were rated on a 5-point scale for agonistic behavior, and the sum of the scores over the 2 test days was the criterion for selection. The six lines, each containing ten breeding pairs, were selected for four generations. By the fourth selected generation, the responses of the high and low lines had diverged in the expected directions. One-way analyses of variance indicated reliable differences among high, low, and control lines in the second, third, and fourth generations. It was concluded that female agonistic behavior is influenced by genotype and that the level of this behavior can be manipulated by means of artificial selection.

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Section: Sex Hormonessupporting

confidence: 84%

Selection for agonistic behavior in wild femaleMus musculus

Ebert

Hyde

1976

Behav Genet

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“…The finding of intraspecific variation in hormone sensitivity in an outbred, naturally occurring species is similar to findings of strain differences in behavioral sensitivity to exogenously administered androgens (21)(22)(23). Since the animals used in this study were collected from a variety of sites, it remains to be determined whether these results reflect population differences and/or are due to enzyme deficiences in nonresponding individuals (24).…”

Section: Discussionsupporting

confidence: 70%

Hormonal Control of Male Reproductive Behavior in the Lizard, Anolis carolinensis: Role of Testosterone, Dihydrotestosterone, and Estradiol*

et al. 1978

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The androgen aromatization hypothesis was examined in the male lizard, Anolis carolinensis. After castration, sc silastic implants of testosterone (T) restored both challenge and courtship behavior, while dihydrotestosterone (DHT) or 17beta-estradiol (E) had no effect on male behaviors. Both T and DHT, but not E, stimulated hypertrophy and colloid production by the renal sex segment, a secondary sexual characteristic of male lizards. In two separate studies, castrates received DHT in combination with E. In each replicate, half of the castrates responded with increases in courtship behavior after hormone treatment. Epithelial cell height of the sex segment of all DHT and E-treated castrates was comparable to T- or DHT-treated castrates, but colloid production was not stimulated. These experiments indicate that in this species, treatment with T stimulates both sexual behavior and secondary sex character development, whereas treatment with E alone is without effect centrally or peripherally.

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“…Overall, these data, along with those of Everett, Holsinger, Zeilmaker, Redmond, and Quinn (1970), Nucci and Beach (1971), and Vale et al ( , 1973, make clear the importance of genotype in the study of the effects of perinatally administered sex hormones. Systematic variation of genotype is a useful approach toward eventual understanding of the basic mechanisms involved in the effects of perinatally administered sex steroid on various behaviors.…”

Section: Discussionmentioning

confidence: 83%

“…Lordosis was rare among these animals, particularly A's and BALB/c's. Some reduction in intromission may be expected in BALB/c's because of an increase in attacks against the male (Vale, Ray, & Vale, 1973) and in A's because of a significant increase in the incidence of defensive postures and running away. However, some reduction in intromission is also attributable to anatomical aberrations due to the EB.…”

Section: Discussionmentioning

confidence: 99%

“…Tests were made in the course of 7 days for aggression and sex behavior. (Aggression data have been reported previously; , 1973 Following 3 days of testing for spontaneous aggression against another female, the animals were tested for male-like sex behavior for M hr with a neonatally untreated estrous C57BL/6 female. (Estrous C57BL/6 females were taken from a common pool and were brought into estrus with injections of EB and progesterone.)…”

Section: Methodsmentioning

confidence: 99%

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The interaction of genotype and exogenous neonatal androgen and estrogen: Sex behavior in female mice

Vale

Ray

Vale

1973

Developmental Psychobiology

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Female neonates of the A, BALB/c, and C57BL/6 mouse strains were injected with androgen, estrogen, or oil and the effects upon their sex behavior studied. Genotype and treatment combined interactively on a substantial number of variables, indicating that the effects of perhatally administered sex hormones and genotype cannot be considered separately. Effects of the 2 hormones were often in different directions. The lordosis response of one genotype appeared relatively insensitive to neonatal treatment, particularly with androgen.

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Interaction of genotype and exogenous neonatal estrogen: Aggression in female mice

Cited by 14 publications

References 9 publications

Selection for agonistic behavior in wild femaleMus musculus

Selection for agonistic behavior in wild femaleMus musculus

Hormonal Control of Male Reproductive Behavior in the Lizard, Anolis carolinensis: Role of Testosterone, Dihydrotestosterone, and Estradiol*

The interaction of genotype and exogenous neonatal androgen and estrogen: Sex behavior in female mice

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