Interaction of gossypol with sperm macromolecules and enzymes

Ueno, Hiroshi; Sahni, Mukesh K.; Segal, Sheldon J.; Koide, S. S.

doi:10.1016/0010-7824(88)90033-9

Cited by 24 publications

(21 citation statements)

References 36 publications

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“…Among these, of particular interest are Schiff base formation with macromolecules [36] and the early, conspicuous damage to mitochondria in the cellular organelle of the spermatogenic cells [33,36]. Other relevant aspects may be found in the Reproductive Toxin section.…”

Section: Male Antifertility Drugmentioning

confidence: 98%

Mechanism of Drug and Toxic Actions of Gossypol: Focus on Reactive Oxygen Species and Electron Transfer

Kovacic¹

2003

CMC

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Gossypol, a constituent of cottonseeds, displays various drug properties, including antifertility and anticancer. Toxicity is shown against the reproductive system, heart, liver, and membranes. The compound exhibits pro- and anti-oxidant behavior. Electron transfer (ET) functionalities, present in gossypol and its metabolites, comprise conjugated dicarbonyl, a quinone derivative, Shiff bases, and metal complexes. The parent possesses a reduction potential favorable for in vivo ET. Considerable evidence points to oxidative stress (OS), formation of reactive oxygen species (ROS), and DNA scission, characteristics of redox cycling by ET in biosystems. Mechanistic aspects are addressed with OS-ROS-ET as the guiding theme, in addition to other modes of action resulting in a multifaceted scenario.

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Section: Male Antifertility Drugmentioning

confidence: 98%

Mechanism of Drug and Toxic Actions of Gossypol: Focus on Reactive Oxygen Species and Electron Transfer

Kovacic¹

2003

CMC

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“…The gossypol-mediated spermatozoid disturbance mechanism includes the inhibition of release and utilization of ATP by the sperm cells [124]. Another effect of gossypol is the reduction of cellular and microtubular β -tubular content in spermatocytes and spermatids [125].…”

Section: Reproductive Effectsmentioning

confidence: 99%

Gossypol Toxicity from Cottonseed Products

Gadelha

Fonseca

Oloris

et al. 2014

The Scientific World Journal

213

174

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Gossypol is a phenolic compound produced by pigment glands in cotton stems, leaves, seeds, and flower buds (Gossypium spp.). Cottonseed meal is a by-product of cotton that is used for animal feeding because it is rich in oil and proteins. However, gossypol toxicity limits cottonseed use in animal feed. High concentrations of free gossypol may be responsible for acute clinical signs of gossypol poisoning which include respiratory distress, impaired body weight gain, anorexia, weakness, apathy, and death after several days. However, the most common toxic effects is the impairment of male and female reproduction. Another important toxic effect of gossypol is its interference with immune function, reducing an animal's resistance to infections and impairing the efficiency of vaccines. Preventive procedures to limit gossypol toxicity involve treatment of the cottonseed product to reduce the concentration of free gossypol with the most common treatment being exposure to heat. However, free gossypol can be released from the bound form during digestion. Agronomic selection has produced cotton varieties devoid of glands producing gossypol, but these varieties are not normally grown because they are less productive and are more vulnerable to attacks by insects.

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“…Indeed, it was observed that this compound blocks the production, release, and use of ATP by spermatozoids (Ueno et al, 1988), promoting ultrastructural changes in mitochondria (Chenoweth et al, 2000;Romualdo et al, 2002). In addition, gossypol inhibited steroidogenic activity in cultivated porcine granulosa cells (Basini et al, 2009).…”

Section: Gossypol Promotes the Degeneration Of Chicken Ovarian Follicmentioning

confidence: 99%

Gossypol Promotes the Degeneration of Chicken Ovarian Follicles in Vitro

Gadelha

Lima

Melo

et al. 2016

Rev. Bras. Cienc. Avic.

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Gossypol, a phenolic compound produced by the pigment glands of cotton, is known to affect male reproduction. In females, exposure to gossypol has been associated with interference with the estrous cycle and embryo development. In laying hens fed cottonseed, gossypol was found to reduce egg production and weight and to cause discoloration of the egg yolk and/or albumen. It is probable that gossypol directly affects ovarian follicles, but this has not been confirmed experimentally yet. Thus, the aim of the present study was to determine if gossypol affected cultivated ovarian follicles of the chicken. Ovarian follicles of adult female chickens were cultivated with different concentrations of gossypol (0, 5, 10 and 20 μg/mL) and classified according to the stage of development as primordial, transitional, primary, secondary or antral, and as viable or atretic. The percentages of viable and atretic follicles in the ovaries cultivated for 24 hours in the presence of gossypol were significantly different from those of the controls for all types of follicles except for secondary follicles, but in all types after cultivation for 7 days. The percentage of viable follicles was higher than that of atretic follicles in ovaries cultivated without gossypol. In contrast, ovaries cultivated with gossypol showed a predominance of atretic follicles. Gossypol increased the proportion of atretic follicles at all stages of development in cultivated chicken ovaries. Thus, gossypol may affect ovarian follicular viability and maturation, which might interfere with female fertility.

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Interaction of gossypol with sperm macromolecules and enzymes

Cited by 24 publications

References 36 publications

Mechanism of Drug and Toxic Actions of Gossypol: Focus on Reactive Oxygen Species and Electron Transfer

Mechanism of Drug and Toxic Actions of Gossypol: Focus on Reactive Oxygen Species and Electron Transfer

Gossypol Toxicity from Cottonseed Products

Gossypol Promotes the Degeneration of Chicken Ovarian Follicles in Vitro

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