Interaction of<i>FKBP5</i>variant rs3800373 and city living alters the neural stress response in the anterior cingulate cortex

Richter, Anja; Al-Bayati, Mohammad; Paraskevopoulou, Foteini; Krämer, Bernd; Pruessner, Jens C.; Binder, Elisabeth B.; Gruber, Oliver

doi:10.1080/10253890.2020.1855420

Cited by 5 publications

(3 citation statements)

References 43 publications

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“…Various neuroimaging studies reported the association between urban environment and functional changes in stress-related brain regions (105,106). Current city living and urban upbringing associated with increased activity in the amygdala-hippocampus complex and subgenual ACC during a stress task in healthy adults (107,108). The ACC is a key region for regulating amygdala function, negative emotions, and stress and has been proposed to mediate the relationship between medial PFC (mPFC) activity and affective symptoms (109).…”

Section: Urbanisationmentioning

confidence: 99%

See 1 more Smart Citation

How does the macroenvironment influence brain and behaviour – a review of current status and future perspectives

Polemiti,

Hese,

Schepanski

et al. 2023

Preprint

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The environment influences mental health, both detrimentally and beneficially. Current research has emphasized the individual psychosocial ‘microenvironment’. Less attention has been paid to ‘macro-environmental’ challenges including climate change, pollution, urbanicity and socioeconomic disparity. With the advent of large-scale big-data cohorts and an increasingly dense mapping of macroenvironmental parameters, we are now in a position to characterise the relation between macroenvironment, brain, and behaviour across different geographic and cultural locations globally. This review synthesises findings from recent epidemiological and neuroimaging studies, aiming to provide a comprehensive overview of the existing evidence between the macroenvironment and the structure and functions of the brain, with a particular emphasis on its implications for mental illness. We discuss putative underlying mechanisms and address the most common exposures of the macroenvironment. Finally, we identify critical areas for future research to enhance our understanding of the aetiology of mental illness and to inform effective interventions for healthier environments and mental health promotion.

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Section: Urbanisationmentioning

confidence: 99%

Section: Urbanisationmentioning

confidence: 99%

How does the macroenvironment influence brain and behaviour – a review of current status and future perspectives

Polemiti,

Hese,

Schepanski

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Therefore, the increased expression of FKBP5 mediated by GCs is considered as an ultrashort, intracellular negative feedback loop that regulates intracellular GR sensitivity [33] (Figure 1). In addition, to understand the paradoxical increase of GCs by exercise, it has been also described that GCs released into the blood eventually reach the mPFC elevating dopamine release, upregulating BDNF [34] and inducing control and coping-related behaviors [35,36]. In contrast, chronic stress and depression have been associated with an overall reduction in dopamine neurotransmission in areas such as PFC, VTA and nucleus accumbens [37].…”

Section: The Unknown Role Of Fkbp5 Protein In the Positive Effects Induced By Aerobic Exercisementioning

confidence: 99%

Building Resilience with Aerobic Exercise: Role of FKBP5

Sampedro-Piquero

Moreno‐Fernández

2021

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: Both preclinical and clinical studies have pointed that aerobic exercise, at moderate doses, is beneficial at all stages of life by promoting a range of physiological and neuroplastic adaptations that reduce the anxiety response. Previous research about this topic have repeatedly described how the regular practice of aerobic exercise induces a positive regulation of neuroplasticity and neurogenesis-related genes, as well as a better control of the HPA axis function. However, limited progress has been carried out in the integration of neuroendocrine and neuroplastic changes, as well as in introducing new factors to understand how aerobic exercise can promote resilience to future stressful conditions. Resilience is defined as the ability to adapt to stress while maintaining healthy mental and physical performance. Consistent findings point to an important role of FKBP5, the gene expressing FK506-binding protein 51 (FKBP51), as a strong inhibitor of the glucocorticoid receptor (GR), and thus, an important regulator of the stress response. We propose that aerobic exercise could contribute to modulate FKBP5 activity acting as a potential therapeutic approach for mood disorders. In this sense, aerobic exercise is well known for increasing the growth factor BDNF, which by downstream pathways could affect the FKBP5 activity. Therefore, our manuscript has the aim of analyzing how FKBP5 could constitute a promising target of aerobic exercise promoting resilient-related phenotypes.

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How does the macroenvironment influence brain and behaviour—a review of current status and future perspectives

Polemiti,

Hese,

Schepanski

et al. 2024

Mol Psychiatry

View full text Add to dashboard Cite

The environment influences brain and mental health, both detrimentally and beneficially. Existing research has emphasised the individual psychosocial ‘microenvironment’. Less attention has been paid to ‘macroenvironmental’ challenges, including climate change, pollution, urbanicity, and socioeconomic disparity. Notably, the implications of climate and pollution on brain and mental health have only recently gained prominence. With the advent of large-scale big-data cohorts and an increasingly dense mapping of macroenvironmental parameters, we are now in a position to characterise the relation between macroenvironment, brain, and behaviour across different geographic and cultural locations globally. This review synthesises findings from recent epidemiological and neuroimaging studies, aiming to provide a comprehensive overview of the existing evidence between the macroenvironment and the structure and functions of the brain, with a particular emphasis on its implications for mental illness. We discuss putative underlying mechanisms and address the most common exposures of the macroenvironment. Finally, we identify critical areas for future research to enhance our understanding of the aetiology of mental illness and to inform effective interventions for healthier environments and mental health promotion.

show abstract

Interaction ofFKBP5variant rs3800373 and city living alters the neural stress response in the anterior cingulate cortex

Cited by 5 publications

References 43 publications

How does the macroenvironment influence brain and behaviour – a review of current status and future perspectives

How does the macroenvironment influence brain and behaviour – a review of current status and future perspectives

Building Resilience with Aerobic Exercise: Role of FKBP5

How does the macroenvironment influence brain and behaviour—a review of current status and future perspectives

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