Interaction of <i>N</i>-nitrosamines with binuclear copper complexes for luminescent detection

Feng, Haosheng; Luo, Shao-Xiong Lennon; Croy, Robert G.; Essigmann, John M.; Swager, Timothy M.

doi:10.1039/d2dt03848j

Cited by 1 publication

(1 citation statement)

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“…A schematic of the potential binding modes is found in Figure b. Generalized binding modes are taken from previous studies on metal-binding interactions with Cu and other metals in the same group as Au. , Interestingly, no crystal structure has ever been reported with a Au and nitrosamine interaction, and reports of noble metal and nitrosamine kinetics extend only to Ag. Other groups have been able to show SERS with N -nitrosodimethylamine (NDMA) and NDEA, however, no kinetics or selectivity have been reported, and subsequently, the selectivity of the binding is poorly understood .…”

Section: Resultsmentioning

confidence: 99%

Detection with NO Modification: (N═O)–Au Interactions for Instantaneous Label-Free Detection of N-Nitrosodiphenylamine

Aligholizadeh,

Johnson,

Hondrogiannis

et al. 2024

Langmuir

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Increasing concerns have been raised about dangerous, yet nearly undetectable levels of nitrosamines in foods, medications, and drinking water. Their ubiquitous presence and carcinogenicity necessitates a method of sensitive and selective detection of these potent toxins. While the detection of two major nitrosamines�Nnitrosodimethylamine and N-nitrosodiethylamine�has seen success, low detection limits are scarcer for the other members of this class. One member, N-nitrosodiphenylamine (NDPhA), has had little progress not only in its detection in low quantities but also in its detection at all. NDPhA has unique difficulty in its identification due to its aromaticity, making it far more problematic to distinguish in the common GC−MS or LC−MS/MS methods used for nitrosamine sensing. Despite this detection barrier, it has been listed among the top 6 carcinogenic nitrosamines by the Food and Drug Administration as of 2023. Due to its evasive nature, a unique methodology must be applied to facilitate its sensitive identification. Herein, we describe the use of surface-enhanced Raman spectroscopy for the first account of liquid-phase detection of NDPhA using cysteamine-functionalized gold nanostars and a portable Raman spectrometer. Our methodology requires no chemical modification to the nitrosated structure as well as the usage of two well-understood biocompatible materials: cysteamine and gold nanoparticles.

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Section: Resultsmentioning

confidence: 99%

Detection with NO Modification: (N═O)–Au Interactions for Instantaneous Label-Free Detection of N-Nitrosodiphenylamine

Aligholizadeh,

Johnson,

Hondrogiannis

et al. 2024

Langmuir

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show abstract

Interaction of N-nitrosamines with binuclear copper complexes for luminescent detection

Abstract: Binuclear Cu(i) complexes bearing N-heterocycles-containing phosphines function as luminescent sensors for N-nitrosamines.

Cited by 1 publication

References 82 publications

Detection with NO Modification: (N═O)–Au Interactions for Instantaneous Label-Free Detection of N-Nitrosodiphenylamine

Detection with NO Modification: (N═O)–Au Interactions for Instantaneous Label-Free Detection of N-Nitrosodiphenylamine

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