Interaction of iodine species with glycogen at high concentrations of iodine

Kumari, Sangeeta; Lecker, Douglas N.; Khan, Arshad

doi:10.1002/(sici)1099-0518(19970415)35:5<927::aid-pola7>3.0.co;2-h

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…Kumari et al [106,107] Also, since the chromophore was due to the I 4 unit within the helix of 11 AGUs, only 44% of the AGUs (11/25) were thought to be involved in the complex formation. These results suggested a strong similarity between the iodine glycogen and the iodineamylopectin structures, as stated above.…”

Section: Iodine-glycogen Complexmentioning

confidence: 99%

Molecular iodine/polymer complexes

Moulay

2013

Journal of Polymer Engineering

166

127

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A unique feature of molecular iodine by far, is its ability to bind to polymeric materials. A plethora of natural and synthetic polymers develop complexes when treated with molecular iodine, or with a mixture of mole cular iodine and potassium iodide. Many unexpected findings have been encountered upon complexation of iodine and the polymer skeleton, including the color formation, the polymer morphology changes, the compl exation sites or regions, the biological activity, and the electrical conductivity enhancement of the complexes, with poly iodides (I n¯) , mainly I 3¯ and I 5¯, as the actual binding species. Natural polymers that afford such complexes with iodine species are starch (amylose and amylopectin), chitosan, glycogen, silk, wool, albumin, cellulose, xylan, and natural rubber; iodinestarch being the oldest iodinenatural polymer complex. By contrast, numerous synthetic polymers are prone to make com plexes, including poly(vinyl alcohol) (PVA), poly(vinyl pyrrolidone) (PVP), nylons, poly(Schiff base)s, poly aniline, unsaturated polyhydrocarbons (carbon nano tubes, fullerenes C 60 /C 70 , polyacetylene; iodinePVA being the oldest iodinesynthetic polymer complex.

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Section: Iodine-glycogen Complexmentioning

confidence: 99%

Molecular iodine/polymer complexes

Moulay

2013

Journal of Polymer Engineering

166

127

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“…These observations were evident through point ( Fig 3a ) and area ( Fig 3b ) analyses of regions of interest. Presumably the iodine preferentially binds to glycogen in erythrocytes [ 36 , 37 ], resulting in a higher iodine content of vasculature distinguishable from other neighboring tissue structures. An early report also noticed vasculature especially blood can be intensely stained by iodine [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Anatomically-specific intratubular and interstitial biominerals in the human renal medullo-papillary complex

Chen¹,

Hsi²,

Yang³

et al. 2017

PLoS ONE

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Limited information exists on the anatomically-specific early stage events leading to clinically detectable mineral aggregates in the renal papilla. In this study, quantitative multiscale correlative maps of structural, elemental and biochemical properties of whole medullo-papillary complexes from human kidneys were developed. Correlative maps of properties specific to the uriniferous and vascular tubules using high-resolution X-ray computed tomography, scanning and transmission electron microscopy, energy dispersive X-ray spectroscopy, and immunolocalization of noncollagenous proteins (NCPs) along with their association with anatomy specific biominerals were obtained. Results illustrated that intratubular spherical aggregates primarily form at the proximal regions distant from the papillary tip while interstitial spherical and fibrillar aggregates are distally located near the papillary tip. Biominerals at the papillary tip were closely localized with 10 to 50 μm diameter vasa recta immunolocalized for CD31 inside the medullo-papillary complex. Abundant NCPs known to regulate bone mineralization were localized within nanoparticles, forming early pathologic mineralized regions of the complex. Based on the physical association between vascular and urothelial tubules, results from light and electron microscopy techniques suggested that these NCPs could be delivered from vasculature to prompt calcification of the interstitial regions or they might be synthesized from local vascular smooth muscle cells after transdifferentiation into osteoblast-like phenotypes. In addition, results provided insights into the plausible temporal events that link the anatomically specific intratubular mineral aggregates with the interstitial biomineralization processes within the functional unit of the kidney.

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“…The specifics of how iodine binds to glycogen have been the subject of much study [21][22][23], but there appears to be little detailed information in the literature that links how initial application of triiodide induces formation of glycogen-iodine complexes. Also, the specifics of how triiodide interacts at the molecular level with other components of animal soft tissues are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Chemical effects of diceCT staining protocols on fluid-preserved avian specimens

et al. 2020

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Diffusible iodine-based contrast-enhanced computed tomography (diceCT) techniques allow visualization of soft tissues of fluid-preserved specimens in three dimensions without dissection or histology. Two popular diceCT stains, iodine-potassium iodide (I 2 KI) dissolved in water and elemental iodine (I 2) dissolved in 100% ethanol (EtOH), yield striking results. Despite the widespread use of these stains in clinical and biological fields, the molecular mechanisms that result in color change and radiopacity attributed to iodine staining are poorly understood. Requests to apply these stains to anatomical specimens preserved in natural history museums are increasing, yet curators have little information about the potential for degradation of treated specimens. To assess the molecular effects of iodine staining on typical museum specimens, we compared the two popular stains and two relatively unexplored stains (I 2 KI in 70% EtOH, I 2 in 70% EtOH). House sparrows (Passer domesticus) were collected and preserved under uniform conditions following standard museum protocols, and each was then subjected to one of the stains. Results show that the three ethanolbased stains worked equally well (producing fully stained, lifelike , publication quality scans) but in different timeframes (five, six, or eight weeks). The specimen in I 2 KI in water became degraded in physical condition, including developing flexible, demineralized bones. The ethanol-based methods also resulted in some demineralization but less than the water-based stain. The pH of the water-based stain was notably acidic compared to the water used as solvent in the stain. Our molecular analyses indicate that whereas none of the stains resulted in unacceptable levels of protein degradation, the bones of a specimen stained with I 2 KI in water demineralized throughout the staining process. We conclude that staining with I 2 KI or elemental I 2 in 70% EtOH can yield high-quality soft-tissue visualization in a timeframe that is similar to that of better-known iodine-based stains, with lower risk of negative impacts on specimen condition.

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Interaction of iodine species with glycogen at high concentrations of iodine

Cited by 3 publications

References 2 publications

Molecular iodine/polymer complexes

Molecular iodine/polymer complexes

Anatomically-specific intratubular and interstitial biominerals in the human renal medullo-papillary complex

Chemical effects of diceCT staining protocols on fluid-preserved avian specimens

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