Interaction of Iron(III)-5,10,15,20-Tetrakis (4-Sulfonatophenyl) Porphyrin with Chloroquine, Quinine and Quinidine

Bibelayi, Dikima D.; Kilunga, Pitchouna I.; Lundemba, Albert S.; Bokolo, Matthieu K.; Mpiana, Pius T.; Tsalu, Philippe Vuka; Pradon, Juliette; Groom, Colin R.; Kadima, Celine W.; Meervelt, Luc Van; Yav, Zéphyrin G.

doi:10.4236/csta.2017.63003

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Coordination complexes have many medicinal, industrial and other pharmacological applications, such as anti-cholesterol, anti-HIV, antibacterial, antifungal, analgesic, antitubercular, and anticancer activities. These references [1][2][3][4][5][6][7][8][9][10] provide their synthetic history. Soriano-García et al (2007) synthesized 3β-(p-iodobenzoyloxy)-16α,17α-epoxypregn-4-En-6,20-dione and used it in the treatment of androgen-dependent diseases [11].…”

Section: Introductionmentioning

confidence: 99%

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2022

ACMCR

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In this study, serval eco-friendly novel complexes were synthesized and characterized having the general formula of [CoC 46 H-60 Cl 2 N 8 O 4 ] (I), [CuC 43 H 53 Cl 2 N 7 O 3 ] (II), [CuC 4 H 16 Cl 2 N 4 O 8 ] (III) and [Cl 4 Zn, C 13 H 28 N 2 , H 2 O] (IV) using benzotriazol, Ethane-1,2-Diamine, and 4,4'-Diaminocyclohexylmethane as ligands through one-pot method using anhydrous methanol or ethanol with different metal salt (2:1 eqv) metal to ligand stoichiometry. The crystal structures of these complexes were determined by X-ray diffraction and further characterized by elemental analysis, ESI-MS, IR, NMR and UV-Vis. Single-crystal XRD studies shows that the structural diversities are mainly affected and controlled by the types of central metal ions. Single-crystal XRD studies also shows that the complexes are coordinated with the ligands through N-metal and O-metal bonds, which revealed their mononuclear geometries. The anticancer activity of these complexes showed cytotoxic effects against human tumour cell Lines A549. Among them the complex (II) showed the best activity with IC 50 values 19.92. The synthesized complexes were also applied for use as organic reaction catalysis and good results were obtained.

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Section: Introductionmentioning

confidence: 99%

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2022

ACMCR

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Metalloporphyrin-Based Fluorescent Sensor for the Discrimination of Volatile Organic Compounds Using Density Functional Theory

Sun

Wang

et al. 2022

Journal of Nanoelectronics and Optoelectronics

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This spectral property of the fluorescent sensors were investigated using density functional theory (DFT) and time-dependent density functional theory (TD-DFT). The considered silver porphyrin (AgP) was selected as a representative dye for the theoretical study of the fluorescent sensors. The molecular structures of AgP and its complexes were optimized at B3LYP/LANL2DZ basis set. The calculated geometry structures, front-line molecular orbitals, absorption spectra, and electronic structures were analyzed to reveal the molecular reaction between AgP-based fluorescent sensors and volatile organic compounds (VOCs). The energy gaps indicated that the efficient orders of AgP-based fluorescent sensor reacted with volatile organic compounds were shown as O2 < N2 < propane (L3) < propaldehyde (L5) < H2S < propanol (L2) < trimethylamine (L1) < ethyl acetate (L6) < butanone (L4). The calculated results all reveal that the AgP-based fluorescent sensor possesses significant changes (i.e., molecular structure, frontline molecular orbital, and absorption spectra) before and after reacting with volatile organic compounds, which are closely related to the selectivity and sensitivity property of AgP-based fluorescent sensor. Therefore, this study may be useful for the AgP-based fluorescent sensor in a special application region.

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Interaction of Iron(III)-5,10,15,20-Tetrakis (4-Sulfonatophenyl) Porphyrin with Chloroquine, Quinine and Quinidine

Cited by 2 publications

References 29 publications

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Metalloporphyrin-Based Fluorescent Sensor for the Discrimination of Volatile Organic Compounds Using Density Functional Theory

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