Interaction of low frequency external electric fields and pancreatic β-cell: a mathematical modeling approach to identify the influence of excitation parameters

Farashi, Sajjad; Sasanpour, Pezhman; Rafii-Tabar, Hashem

doi:10.1080/09553002.2018.1478162

Cited by 4 publications

(3 citation statements)

References 54 publications

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“…Alteration in the size of pancreatic islets and changes in the cell membrane electrical activity are the suggested mechanisms for the effects of EMF on the pancreas function and insulin release (Farashi et al, 2018). Oxidative stress is also a well-known mediator in the occurrence of pathological lesions and degenerative effects in the pancreatic endocrine (including beta cells) and exocrine cells (Farahna et al, 2014;Sakurai et al, 2008;Topsakal et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Alteration of intrapancreatic serotonin, homocysteine, TNF-α, and NGF levels as predisposing factors for diabetes following exposure to 900-MHz waves

et al. 2021

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Exposure to mobile phone radiation causes deleterious health effects on biological systems. The objects of this study were to investigate the effect of 900-MHz radiofrequency waves (RFW) emitted from base transceiver station antenna on intrapancreatic homocysteine (Hcy), tumor necrosis factor-α (TNF-α), and nerve growth factor (NGF) as predisposing factors involved in pancreatic beta cell damage. Thirty male rats (Sprague-Dawley, 200 ± 10 g) were randomly divided into the control (without any exposure) and exposed groups: short time (2 h/day), long time (4 h/day), and exposed to 900-MHz RFW for 30 consecutive days. On the last days of the experiment, animals were killed and pancreas tissue was dissected out for evaluation of serotonin, Hcy, TNF-α, and NGF. There was a significant decrease in the serotonin and NGF levels in the pancreatic tissue of exposed groups compared to the control group ( p < 0.05). Also, the levels of serotonin and NGF in the long-time exposure were significantly lower than the short-time exposure ( p < 0.05). However, levels of Hcy and TNF-α were significantly increased in the pancreas of exposed groups compared to the control groups ( p < 0.05). Exposure to 900-MHz RFW decreased pancreatic NGF and serotonin levels and increased the proinflammatory markers (Hcy and TNF-α), which can be a predisposing factor for type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Alteration of intrapancreatic serotonin, homocysteine, TNF-α, and NGF levels as predisposing factors for diabetes following exposure to 900-MHz waves

et al. 2021

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“…One work has demonstrated that ELF-EMFs can enhance insulin secretion by increasing the number of pancreatic cells [78,81]. Other studies have shown that insulin secretion of cells can be boosted when the frequency of EMFs is consistent with the inherent frequency [82,83]. Another study has reported that EMFs can lower blood glucose level by affecting the endocrine system [77].…”

Section: Diabetesmentioning

confidence: 99%

The Effects of Electromagnetic Fields on Human Health: Recent Advances and Future

et al. 2021

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The potential of electromagnetic fields (EMFs) for disease treatment and health enhancement has been actively pursued over the recent decades. This review first provides a general introduction about natural EMFs and related biological effects. Then the recent progress on the EMF treatment of some common diseases (such as cancer, diabetes, wound healing and neurological diseases, etc.) has been carefully reviewed and summarized. Yet, the blindness on the selection of therapeutic EMF parameters still hinders the broad ap-plication of EMF therapy. Moreover, the unclear mechanism of EMF function and poor reproducibility of experimental results also remain big challenges in the field of bioelectromagnetics. Bionics is a useful methodology that gains inspiration from nature to serve human life and industry. We have discussed the feasibility of applying bionic approach on the selection of therapeutic EMFs, which is based on the findings of natural EMFs. Finally, we advocate that the detailed information of EMFs and biological samples should be thoroughly rec-orded in future research and reported in publications. In addition, the publication of studies with negative results should also be allowed.

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“…Moreover, a more recent study has shown that the external electric field can positively influence the membrane electrical activity and perhaps the insulin secretion of pancreatic β -cell when its amplitude exceeds a threshold value. Furthermore, it has been shown that different waveforms have distinct effects on the β -cell membrane electrical activity and the characteristic features of the excitation like frequency would change the interaction mechanism [3]. Generally, focus was given to identifying the intensity and field parameters that result in a positive effect on human cells.…”

Section: Introductionmentioning

confidence: 99%

Combined Optimized Effect of a Highly Self-Organized Nanosubstrate and an Electric Field on Osteoblast Bone Cells Activity

Portan

Deligianni

Papanicolaou

et al. 2019

BioMed Research International

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The effect of an electric field within specific intensity limits on the activity of human cells has been previously investigated. However, there are a considerable number of factors that influence the in vitro development of cell populations. In biocompatibility studies, the nature of the substrate and its topography are decisive in osteoblasts bone cells development. Further on, electrical field stimulation may activate biochemical paths that contribute to a faster, more effective self-adjustment and proliferation of specific cell types on various nanosubstrates. Within the present research, an electrical stimulation device has been manufactured and optimum values of parameters that led to enhanced osteoblasts activity, with respect to the alkaline phosphatase and total protein levels, have been found. Homogeneous electric field distribution induced by a highly organized titanium dioxide nanotubes substrate had an optimum effect on cell response. Specific substrate topography in combination with appropriate electrical stimulation enhanced osteoblasts bone cells capacity to self-adjust the levels of their specific biomarkers. The findings are of importance in the future design and development of new advanced orthopaedic materials for hard tissue replacement.

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Interaction of low frequency external electric fields and pancreatic β-cell: a mathematical modeling approach to identify the influence of excitation parameters

Abstract: The results could help the researchers to investigate the possible role of the environmental electromagnetic fields on the promotion of diabetes disease.

Cited by 4 publications

References 54 publications

Alteration of intrapancreatic serotonin, homocysteine, TNF-α, and NGF levels as predisposing factors for diabetes following exposure to 900-MHz waves

Alteration of intrapancreatic serotonin, homocysteine, TNF-α, and NGF levels as predisposing factors for diabetes following exposure to 900-MHz waves

The Effects of Electromagnetic Fields on Human Health: Recent Advances and Future

Combined Optimized Effect of a Highly Self-Organized Nanosubstrate and an Electric Field on Osteoblast Bone Cells Activity

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