2020
DOI: 10.1124/mol.120.119982
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Interaction of MDIMP with the Voltage-Gated Calcium Channels

Abstract: Amino acid-derived isoindolines are synthetic compounds that were created with the idea of investigating their biological actions. The amino acid moiety was included on the grounds that it may help to avoid toxic effects. Recently, the isoindoline MDIMP was shown to inhibit both cardiac excitation-contraction coupling and voltage-dependent calcium channels. Here, we revealed that MDIMP binds preferentially to low-voltage-activated (LVA) channels. Using a holding potential of 290 mV, the following IC 50 values … Show more

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