Microplastics pollution of terrestrial and marine environmental compartments is an issue of concern worldwide, but information on the key sources, pathways, distribution, and impacts is still scarce in many cases, fragmentary at best, and typically difficult to compare owing to a lack of harmonization in methodologies. In this chapter, we present the latest evidence of microplastics as a global threat, together with current knowledge gaps, the challenges associated with establishing a global monitoring system and what legislative framework might be needed for