2013
DOI: 10.1002/prot.24267
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Interaction of metal chelators with different molecular forms of acetylcholinesterase and its significance in Alzheimer's disease treatment

Abstract: The peripheral anionic site (PAS) of acetylcholinesterase (AChE) is involved in amyloid beta (Aβ) peptides aggregation of Alzheimer's disease (AD). AChE exhibits an aryl acylamidase (AAA) activity along with the well known esterase activity. Numerous studies have reported the beneficiary effect of metal chelators in AD treatment. Hence, a comparative study on the effect of metal chelators on both the esterase and AAA activity of AChE globular (G4 and G1) molecular forms was performed. The inhibitory effect of … Show more

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Cited by 9 publications
(1 citation statement)
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“…From the evidence of various researches, it is therefore pertinent to infer that deposition and accumulation of iron in the brain is a centre point of all the neuropathological operations which is not limited to amyloid plaques, tau phosphorylation, as well as oxidative stress in AD. There is adequate evidence to pin down interaction of Aβ and transition metal especially neocortical iron as the culprit in initiating and causing the toxicity observed in AD .…”
Section: Introductionmentioning
confidence: 99%
“…From the evidence of various researches, it is therefore pertinent to infer that deposition and accumulation of iron in the brain is a centre point of all the neuropathological operations which is not limited to amyloid plaques, tau phosphorylation, as well as oxidative stress in AD. There is adequate evidence to pin down interaction of Aβ and transition metal especially neocortical iron as the culprit in initiating and causing the toxicity observed in AD .…”
Section: Introductionmentioning
confidence: 99%