Interaction of metal ions with d-glucobenzothiazoline: isolation and characterization of the resultant products

Das, Thangamuthu Mohan; Rao, Chebrolu P.; Kolehmainen, Erkki; Kadam, R.M.; Sastry, M. D.

doi:10.1016/s0008-6215(01)00317-2

Cited by 7 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…30 The absorption spectra of 3 and 4 revealed one intense band around 400 nm, which corresponds to the metal to ligand charge-transfer transitions. 31 All the complexes displayed strong band in the UV region at 257-277 nm attributed to π -π* transition. 32 EPR Spectra.…”

Section: Resultsmentioning

confidence: 96%

DNA Binding Studies of Novel Copper(II) Complexes Containing l-Tryptophan as Chiral Auxiliary: In Vitro Antitumor Activity of Cu−Sn₂ Complex in Human Neuroblastoma Cells

2007

View full text Add to dashboard Cite

Novel trinuclear complexes C23H31N6O6CuSn2Cl5 [1], C23H31N6O6CuZr2Cl5 [2], C23H31N6O6ZnSn2Cl5 [3], and C23H31N6O6ZnZr2Cl5 [4] were synthesized and characterized by spectroscopic (IR, 1H, 13C, 2D COSY, and 119Sn NMR, EPR, UV-vis, ESI-MS) and analytical methods. In complexes 1-4, the geometry of copper and zinc metal ions were described as square-based pyramidal with l-tryptophan coordinated to copper/zinc via carboxylate group while Sn/Zr was present in the hexacoordinate environment. The interaction of 1 and 2 with calf thymus DNA in Tris buffer was studied by electronic absorption titration, luminescence titration, cyclic voltammetry, circular dichroism, and viscometric measurements. The emission quenching of these complexes by [Fe(CN)6]4- depressed greatly when bound to DNA. Observed changes in the circular dichoric spectra of DNA in presence of 1 and 2 support the strong binding of complexes with DNA. The relative specific viscosity of DNA bound to 1 and 2 decreased, indicating that the complexes bind to DNA via covalent binding. The results reveal that the extent of DNA binding of 1 was greater than that of 2. To evaluate the mechanistic pathway of DNA inhibition, counting experiments and MTT assay were employed to assess the induction of apoptosis by 1. Western blot analysis of whole cell lysates and mitochondrial fractions with Bcl-2 and p-53 family proteins and caspase-3 colorimetry assay were also carried out on a human neuroblastoma cell line SY5Y.

show abstract

Section: Resultsmentioning

confidence: 96%

DNA Binding Studies of Novel Copper(II) Complexes Containing l-Tryptophan as Chiral Auxiliary: In Vitro Antitumor Activity of Cu−Sn₂ Complex in Human Neuroblastoma Cells

2007

View full text Add to dashboard Cite

show abstract

Cupric Halide‐Mediated Intramolecular Halocyclization of N‐Electron‐Withdrawing Group‐Substituted 2‐Alkynylanilines for the Synthesis of 3‐Haloindoles

Shen

2009

Adv Synth Catal

View full text Add to dashboard Cite

A convenient and efficient method for the synthesis of 3-haloindoles has been developed. Both 3-chloro-and 3-bromoindole derivatives can be obtained in high yields by the reaction of N-electron-withdrawing group-substituted 2-alkynylanilines with cupric halide in dimethyl sulfoxide (DMSO) within a short period of time. Investigation of the reaction mechanism reveals that two equivalents of cupric halide are necessary.

show abstract

Synthesis and characterization of 4,6-O-butylidene-N-(2-hydroxybenzylidene)-β-d-glucopyranosylamine: crystal structures of 4,6-O-butylidene-α-d-glucopyranose, 4,6-O-butylidene-β-d-glucopyranosylamine and 4,6-O-butylidene-N-(2-hydroxybenzylidene)-β-d-glucopyranosylamine

Rajsekhar

Gangadharmath

Rao

et al. 2002

Carbohydrate Research

View full text Add to dashboard Cite

Interaction of metal ions with d-glucobenzothiazoline: isolation and characterization of the resultant products

Cited by 7 publications

References 18 publications

DNA Binding Studies of Novel Copper(II) Complexes Containing l-Tryptophan as Chiral Auxiliary: In Vitro Antitumor Activity of Cu−Sn₂ Complex in Human Neuroblastoma Cells

DNA Binding Studies of Novel Copper(II) Complexes Containing l-Tryptophan as Chiral Auxiliary: In Vitro Antitumor Activity of Cu−Sn₂ Complex in Human Neuroblastoma Cells

Cupric Halide‐Mediated Intramolecular Halocyclization of N‐Electron‐Withdrawing Group‐Substituted 2‐Alkynylanilines for the Synthesis of 3‐Haloindoles

Synthesis and characterization of 4,6-O-butylidene-N-(2-hydroxybenzylidene)-β-d-glucopyranosylamine: crystal structures of 4,6-O-butylidene-α-d-glucopyranose, 4,6-O-butylidene-β-d-glucopyranosylamine and 4,6-O-butylidene-N-(2-hydroxybenzylidene)-β-d-glucopyranosylamine

Contact Info

Product

Resources

About

Interaction of metal ions with d-glucobenzothiazoline: isolation and characterization of the resultant products

Cited by 7 publications

References 18 publications

DNA Binding Studies of Novel Copper(II) Complexes Containing l-Tryptophan as Chiral Auxiliary: In Vitro Antitumor Activity of Cu−Sn2 Complex in Human Neuroblastoma Cells

DNA Binding Studies of Novel Copper(II) Complexes Containing l-Tryptophan as Chiral Auxiliary: In Vitro Antitumor Activity of Cu−Sn2 Complex in Human Neuroblastoma Cells

Cupric Halide‐Mediated Intramolecular Halocyclization of N‐Electron‐Withdrawing Group‐Substituted 2‐Alkynylanilines for the Synthesis of 3‐Haloindoles

Synthesis and characterization of 4,6-O-butylidene-N-(2-hydroxybenzylidene)-β-d-glucopyranosylamine: crystal structures of 4,6-O-butylidene-α-d-glucopyranose, 4,6-O-butylidene-β-d-glucopyranosylamine and 4,6-O-butylidene-N-(2-hydroxybenzylidene)-β-d-glucopyranosylamine

Contact Info

Product

Resources

About

DNA Binding Studies of Novel Copper(II) Complexes Containing l-Tryptophan as Chiral Auxiliary: In Vitro Antitumor Activity of Cu−Sn₂ Complex in Human Neuroblastoma Cells

DNA Binding Studies of Novel Copper(II) Complexes Containing l-Tryptophan as Chiral Auxiliary: In Vitro Antitumor Activity of Cu−Sn₂ Complex in Human Neuroblastoma Cells