Interaction of metformin hydrochloride with ionic surfactants in aqueous and NaCl solution: Effect of temperatures and compositions

Abstract

Herein, the interaction of metformin hydrochloride (MNH) with cetyltrimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS) has been investigated by the conductometric technique in aqueous medium as well as in the existence of NaCl over a range of temperatures. MNH, an antidiabetic drug that belongs to the biguanide group, is generally prescribed for the patients to manage type II diabetes. The micellar parameters such as critical micelle concentration (CMC), the extent of counterion binding (β), and different thermodynamic properties for MNH + surfactant systems were estimated and discussed elaborately. The CMC values of CTAB + MNH and SDS + MNH systems are dependent on the concentrations of NaCl at different temperatures. The significant decrease of CMC values in NaCl solution indicates that NaCl stabilizes MNH‐mediated surfactant micelles. The CMC values versus T plots show a nonlinear pattern for the CTAB + MNH system, whereas the CMC values almost monotonically decrease with increasing temperature for the SDS + MNH system. The values of ∆G0m were negative for both systems in all cases. Both ∆G0m and ∆G0m,t values indicate that the aggregation processes of MNH + surfactants mixture are spontaneous, which is also manifested in NaCl solution and with the change of temperatures in most of the cases. The obtained results proposed that surfactants may assist as a proficient drug delivery agent for antidiabetic drug, enhancing their bioavailability.

The Assembly of the Mixture of Two Ionic Surfactants in Polyols Media at Variable Temperatures: Combined Conductivity and Theoretical Investigations

“…Therefore, the mixed micelle development is due to the extreme attraction between TTAB and CTAB. The attractive interaction between the TTAB and CTAB amphiphiles is reasonable with literature (Tables 1-3) (Alam et al, 2019a;Esan et al, 2015;Hoque et al, 2020). Although similar The micellization process of amphiphiles and their mixtures is known to be affected in the occurrence of additives including polyols, electrolytes, drugs, polymers, and proteins, etc.…”

“…Various combinations of surfactants such as cationic-cationic, anionic-anionic, cationic-anionic, anionic-nonionic, and nonionic-cationic, have quantitively been analyzed to estimate the physicochemical features (Alam et al, 2019a;Penfold et al, 1999). Rubingh theory was employed to evaluate the mutual interaction occurring among surfactants in the mixed micellar state (Basu et al, 2007;Hoque et al, 2020;Motomura et al, 1984).…”

A recent overview of surfactant–drug interactions and their importance

“…The CMC values were dropped in the presence of NaCl, and they dropped even more sharply when the amount of NaCl was raised at a specific temperature. 63 This effect is consistent with observations from other systems that include ionic surfactants when NaCl is present. 64 The strong electrical repulsion between the ionic surfactant's positively charged head groups was much diminished, which was the main cause of the decline in CMC values.…”

Solubility Measurement and Data Correlation of Metformin Hydrochloride in Four Aqueous Binary Solvents and Three Pure Solvents from 283.15 to 323.15 K

“…Metformin hydrochloride (MET·HCl, C 4 H 11 N 5 , CAS registry number: 1115-70-4, Figure ), 3-(diaminomethylidene)-1,1-dimethylguanidine hydrochloride, , is currently one of the most widely used oral hypoglycemic drugs in the world. Its main mechanism of action is to inhibit the production of glucose in the liver and reduce the output of glucose .…”