Interaction of Microcrystalline Cellulose and Water in Granules Prepared by a High-Shear Mixer.

Abstract

Microcrystalline cellulose (MCC) granules were prepared by wet granulation using a high-shear mixer. Physical characteristics of the granules were investigated using near IR spectrometry, thermogravimetry and isothermal water vapor adsorption. Near IR spectra of dried MCC granules prepared for various granulation times exhibited different peak intensities at 1428, 1772, and 1920 nm, which were assigned to functional groups of cellulose or water. On isothermogravimetric analysis, the rate of dehydration of water was shown to decrease with granulation time. These results suggest that the physical structure of MCC could change during the granulation process, and the interaction between MCC and water was gradually strengthened. The isothermal water vapor adsorption curves suggested that the amorphous region of MCC would be divided by the strong shear force of the impeller, because the high adsorption ability of intact MCC in the low humidity region was diminished in granules collected following 5 and 10 min of granulation. It was suggested that MCC formed a network which caught water within its structure during the wet granulation process.

Aquaphotomics Investigation of Electrolyzed Hydrogen Water: Understanding the Water Molecular Structure and Its Role in Scavenging Reactive Oxygen Species

“…The presence of all three bands in discriminating power indicates possibility of presence of hydrated CH containing structures. Additionally, the bands 1482 nm and 1772 nm, that can also be seen featured in discriminating power were found in another work related to presence of granules [77]. Granules in the case of examined water samples might be granulated nanoparticles and/or biochar granules.…”

Effect of Moisture on Impact Toughness of Sugar-Coated Tablets Manufactured by the Dusting Method

“…There have been a number of reports regarding the effect of moisture on MCC properties and the moisture sorption and desorption of MCC. [11][12][13][14] Fielden et al reported that MCC was capable of physically retaining a high percentage of water within itself, while also allowing easy removal by evaporation.11) Suzuki et al reported that the physical structure of MCC changed during the wet granulation process, and the interaction between MCC and water was gradually strengthened.12) Moisture thus affects the physical properties of MCC.Although there have been several reports regarding the relationship between moisture and color change on sugarcoated tablets, 15-17) the effect of moisture on impact toughness of sugar-coated tablets has not been sufficiently clarified. Above all, the effect of moisture on impact toughness of sugar-coated tablets with MCC has not been sufficiently clarified.…”

“…There have been a number of reports regarding the effect of moisture on MCC properties and the moisture sorption and desorption of MCC. [11][12][13][14] Fielden et al reported that MCC was capable of physically retaining a high percentage of water within itself, while also allowing easy removal by evaporation. 11) Suzuki et al reported that the physical structure of MCC changed during the wet granulation process, and the interaction between MCC and water was gradually strengthened.…”

“…11) Suzuki et al reported that the physical structure of MCC changed during the wet granulation process, and the interaction between MCC and water was gradually strengthened. 12) Moisture thus affects the physical properties of MCC.…”