Interaction of monodispersed strontium containing bioactive glass nanoparticles with macrophages

Naruphontjirakul, Parichart; Li, Siwei; Pinna, Alessandra; Barrak, Fadi; Chen, Shu; Redpath, Andia N.; Rankin, Sara M.; Porter, Alexandra E.; Jones, Julian R.

doi:10.1016/j.msec.2021.112610

Cited by 16 publications

(14 citation statements)

References 67 publications

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“…It was previously demonstrated that Sr-containing BAGNPs (Sr-BAGNPs) pro-moted ion release that could potentially enhance mineralizing actions and osteogenic differentiation [ 24 , 27 ]. However, adding Zn to improve the bioactivity of BAGNPs was challenged.…”

Section: Discussionmentioning

confidence: 99%

“…Sr is a divalent cation (Sr 2+ ), which closely resembles calcium (Ca 2+ ) in its atomic and ionic properties. This biologically beneficial element that is plentiful in human tissues has been reported to promote bone formation because of its capability to stimulate bone formation by activating osteoblasts [ 24 , 25 , 26 ] and to prevent bone resorption by inhibiting osteoclasts [ 26 , 27 ]. Therefore, Sr has been introduced to sol–gel-derived BAGs to increase new bone formation.…”

Section: Introductionmentioning

confidence: 99%

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Zinc-Containing Sol–Gel Glass Nanoparticles to Deliver Therapeutic Ions

et al. 2022

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Zn-containing dense monodispersed bioactive glass nanoparticles (Zn-BAGNPs) have been developed to deliver therapeutic inorganic trace elements, including Si, Ca, Sr, and Zn, to the cells through the degradation process, as delivery carriers for stimulating bone regeneration because of their capacity to induce osteogenic differentiation. The sol–gel-derived dense silica nanoparticles (SiO2-NPs) were first synthesized using the modified Stöber method, prior to incorporating therapeutic cations through the heat treatment process. The successfully synthesized monodispersed Zn-BAGNPs (diameter of 130 ± 20 nm) were homogeneous in size with spherical morphology. Ca, Sr and Zn were incorporated through the two-step post-functionalization process, with the nominal ZnO ratio between 0 and 2 (0, 0.5, 1.0, 1.5 and 2.0). Zn-BAGNPs have the capacity for continuous degradation and simultaneous ion release in SBF and PBS solutions due to their amorphous structure. Zn-BAGNPs have no in vitro cytotoxicity on the murine pre-osteoblast cell (MC3T3-E1) and periodontal ligament stem cells (PDLSCs), up to a concentration of 250 µg/mL. Zn-BAGNPs also stimulated osteogenic differentiation on PDLSCs treated with particles, after 2 and 3 weeks in culture. Zn-BAGNPs were not toxic to the cells and have the potential to stimulate osteogenic differentiation on PDLSCs. Therefore, Zn-BAGNPs are potential vehicles for therapeutic cation delivery for applications in bone and dental regenerations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Zinc-Containing Sol–Gel Glass Nanoparticles to Deliver Therapeutic Ions

et al. 2022

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“…Sr induces macrophages to differentiate toward the pro-regenerative type M2 instead of the pro-inflammatory type M1 [ 28 ]. An in vitro study showed that Sr inhibited the inflammatory response of macrophages, and further weakened the inhibitory effect of the inflammatory response to osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) [ 29 ].…”

Section: Mechanisms Of Sr On Bone Regenerationmentioning

confidence: 99%

Recent Advance of Strontium Functionalized in Biomaterials for Bone Regeneration

et al. 2023

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Bone defect disease causes damage to people’s lives and property, and how to effectively promote bone regeneration is still a big clinical challenge. Most of the current repair methods focus on filling the defects, which has a poor effect on bone regeneration. Therefore, how to effectively promote bone regeneration while repairing the defects at the same time has become a challenge for clinicians and researchers. Strontium (Sr) is a trace element required by the human body, which mainly exists in human bones. Due to its unique dual properties of promoting the proliferation and differentiation of osteoblasts and inhibiting osteoclast activity, it has attracted extensive research on bone defect repair in recent years. With the deep development of research, the mechanisms of Sr in the process of bone regeneration in the human body have been clarified, and the effects of Sr on osteoblasts, osteoclasts, mesenchymal stem cells (MSCs), and the inflammatory microenvironment in the process of bone regeneration have been widely recognized. Based on the development of technology such as bioengineering, it is possible that Sr can be better loaded onto biomaterials. Even though the clinical application of Sr is currently limited and relevant clinical research still needs to be developed, Sr-composited bone tissue engineering biomaterials have achieved satisfactory results in vitro and in vivo studies. The Sr compound together with biomaterials to promote bone regeneration will be a development direction in the future. This review will present a brief overview of the relevant mechanisms of Sr in the process of bone regeneration and the related latest studies of Sr combined with biomaterials. The aim of this paper is to highlight the potential prospects of Sr functionalized in biomaterials.

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“…Macrophages, an essential regulator of innate and adaptive immunity, are critical cells recruited by polymorphonuclear leukocytes (PMN) upon detection of pathogens ( Parisi et al, 2018 ). The role of macrophages is mainly through the following ways: 1) Eliminating cellular debris, dead cells and pathogens by phagocytosis; 2) initiating appropriate or pathogenic inflammatory responses (mainly by M1 macrophages); 3) secreting proteins that stimulate wound healing, such as cytokines and enzymes (specifically by M2 macrophages) ( Naruphontjirakul et al, 2021 ). Increasing evidence suggests that macrophages associated with implanted biomaterials play an important role in bone formation, as macrophages take a dynamic role in initiating the recruitment of MSCs and vascular progenitor cells engaged in angiogenesis ( Nair and Tang, 2017 ; Niu et al, 2017 ; Yang et al, 2018 ; Xie et al, 2020 ; Niu et al, 2021 ).…”

Section: Immunological Mechanism Of Strontium For Osteogenesismentioning

confidence: 99%

“…At present, Sr 2+ has been successfully applied in the osteoporosis therapy, among which strontium ranelate has been widely used in clinical practice and has shown an ideal therapeutic effect in the treatment of osteoporosis patients ( Neves et al, 2017 ; Marx et al, 2020 ). Numerous researches have shown that a range of Sr 2+ -doped biomaterials, such as Sr 2+ -doped bone cement, Sr 2+ -doped bioactive glasses and Sr 2+ -composite bioactive coatings, can further accelerate bone formation around the bone defect ( Kargozar et al, 2019 ; Naruphontjirakul et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Strontium Functionalized in Biomaterials for Bone Tissue Engineering: A Prominent Role in Osteoimmunomodulation

You

Zhang

Zhou

2022

Front. Bioeng. Biotechnol.

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With the development of bone tissue engineering bio-scaffold materials by adding metallic ions to improve bone healing have been extensively explored in the past decades. Strontium a non-radioactive element, as an essential osteophilic trace element for the human body, has received widespread attention in the medical field due to its superior biological properties of inhibiting bone resorption and promoting osteogenesis. As the concept of osteoimmunology developed, the design of orthopedic biomaterials has gradually shifted from “immune-friendly” to “immunomodulatory” with the aim of promoting bone healing by modulating the immune microenvironment through implanted biomaterials. The process of bone healing can be regarded as an immune-induced procedure in which immune cells can target the effector cells such as macrophages, neutrophils, osteocytes, and osteoprogenitor cells through paracrine mechanisms, affecting pathological alveolar bone resorption and physiological bone regeneration. As a kind of crucial immune cell, macrophages play a critical role in the early period of wound repair and host defense after biomaterial implantation. Despite Sr-doped biomaterials being increasingly investigated, how extracellular Sr2+ guides the organism toward favorable osteogenesis by modulating macrophages in the bone tissue microenvironment has rarely been studied. This review focuses on recent knowledge that the trace element Sr regulates bone regeneration mechanisms through the regulation of macrophage polarization, which is significant for the future development of Sr-doped bone repair materials. We will also summarize the primary mechanism of Sr2+ in bone, including calcium-sensing receptor (CaSR) and osteogenesis-related signaling pathways.

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Interaction of monodispersed strontium containing bioactive glass nanoparticles with macrophages

Cited by 16 publications

References 67 publications

Zinc-Containing Sol–Gel Glass Nanoparticles to Deliver Therapeutic Ions

Zinc-Containing Sol–Gel Glass Nanoparticles to Deliver Therapeutic Ions

Recent Advance of Strontium Functionalized in Biomaterials for Bone Regeneration

Strontium Functionalized in Biomaterials for Bone Tissue Engineering: A Prominent Role in Osteoimmunomodulation

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