Interaction of Noradrenergic Pharmacological Manipulation and Subthalamic Stimulation on Movement Initiation Control in Parkinson's Disease

Clonidine modulates the activity of the subthalamic‐supplementary motor loop: evidence from a pharmacological study combining deep brain stimulation and electroencephalography recordings in Parkinsonian patients

“…; Albares et al . ). In accordance with this view, difficulties initiating movements are associated with pathological overactivity within the proactive inhibitory brain network (Criaud et al .…”

“…; Albares et al . ). Clonidine could impede the positive action of STN‐DBS on movement initiation by blocking the ability to release proactive activity within the inhibitory network (Albares et al .…”

“…Clonidine could impede the positive action of STN‐DBS on movement initiation by blocking the ability to release proactive activity within the inhibitory network (Albares et al . ). (b) Electroencephalography (EEG) offers the possibility to track relevant spectral activity, directly at the source level after blind source separation and DBS artifacts removal.…”

“…A recent behavioral study in PD combining pharmacological manipulation using clonidine and STN‐DBS suggests that the NA system plays a role in the positive action of STN‐DBS on movement initiation latency (Albares et al . ). However, there is still no direct neural evidence in humans that the NA system modulates the activity of the subthalamic‐cortical loops involved in motor control.…”

“…The behavioral results of this experiment have been described in a former publication (Albares et al . ). Recent methodological advances from our group allowed us to remove DBS‐induced electrical artifacts (Allen et al .…”