Interaction of Per- and Polyfluoroalkyl Substances and Allostatic Load among Adults in Various Occupations

Bashir, Tahir; Obeng-Gyasi, Emmanuel

doi:10.3390/diseases10020026

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…For decades, per- and polyfluoroalkyl substances (PFAS) chemicals have been widely used in various consumer, medical, and industrial products. − Owing to environmental persistence and being notoriously hazardous, the long-chain PFAS chemicalsperfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS)have been prohibited under international regulations. , However, many short-chain fluorinated alternatives remain in use, and they could also be accumulated via physicochemical degradation pathways of longer-chain PFAS. − Even though the use of hydrated electron (e aq – )-based advanced reductive technology (e aq – -ART) has recently shown to be effective to destruct both perfluoroalkyl carboxylates (PFxA, x = number of carbons comprising the hydrophobic tail) and perfluoroalkyl sulfonates (PFxS), − PFxS with short fluoroalkyl chains such as PFBS (C 4 F 9 SO 3 – ) remains an exceptional case and displays very sluggish reactivity . To date, the abundance of short-chain PFAS from numerous sources has already been detected in most locations on the planet. − Recent toxicological studies revealed that the potential threats to human health posed by analogs had been underestimated due to increased solubility, mobility, and inertness. − Thus, their complete removal and decomposition from the aquatic environment has become an urgent concern.…”

Section: Introductionmentioning

confidence: 99%

Transient Kinetics of Short-Chain Perfluoroalkyl Sulfonate with Radiolytic Reducing Species

Jiang

Adjei

Denisov

et al. 2022

Environ. Sci. Technol. Lett.

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The role of the short-lived hydrated electron (e aq − ) has recently begun to be appreciated in per-and polyfluoroalkyl substances (PFAS) remediations; nevertheless, few studies to date focused on short-chain PFAS, and their effective defluorination has been limited by an insufficient mechanistic understanding, which starts with the elusive initial step of e aq − reduction. Herein, this study uses pulse radiolysis to clarify the rate constant of the e aq − reaction with a highly recalcitrant short-chain PFAS, perfluorobutanesulfonate (PFBS, C 4 F 9 SO 3 − ), and verify chain length dependence. The measured values contradict earlier results from laser photolysis but reconcile with the apparent degradation profiles and theoretical predictions. Besides, we first disclose radiolytic carbon dioxide radicals (CO 2 −• ) to defluorinate PFBS with an initial reaction constant of 4.8 × 10 7 M −1 s −1 , and it achieves selective cleavage on the more obstinate C−F bond than e aq − even under a neutral condition. Quantitative 60 Co γ-ray irradiation experiments further show that initial reduction occurs through a defluorination pathway rather than a desulfurization pathway, and the redox potential of PFBS exceeds −2.0 eV. This radiolytic study addressed the long-standing mechanistic contradictions regarding short-chain PFAS degradation and suggested ionizing radiation as a versatile and direct treatment technique.

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Section: Introductionmentioning

confidence: 99%

Transient Kinetics of Short-Chain Perfluoroalkyl Sulfonate with Radiolytic Reducing Species

Jiang

Adjei

Denisov

et al. 2022

Environ. Sci. Technol. Lett.

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“…Occupation plays a pivotal role in determining stress levels [ 40 , 41 ]. High-stress occupations with demanding work environments can lead to elevated stress, burnout, and negative impacts on mental and physical health.…”

Section: Discussionmentioning

confidence: 99%

Chronic Stress Indicator: A Novel Tool for Comprehensive Stress Analysis

Hill,

Mostafa,

Obeng-Gyasi

2024

IJERPH

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Extensive research has highlighted the strong association between chronic stress and negative health outcomes. This relationship is influenced by various factors, including sociobehavioral, environmental, and genetic and epigenomic forces. To comprehensively assess an individual’s stress levels, we propose the development of the Chronic Stress Indicator (CSI), a novel comprehensive multifaceted tool that incorporates key biological, anthropometric, behavioral, and socioeconomic factors. The objective of this study is to assess the effectiveness of the CSI compared to Allostatic Load (AL), a type of chronic stress, in identifying health issues related to stress. The objective of this research is to evaluate the performance of the Chronic Stress Indicator (CSI) versus Allostatic Load (AL) in detecting adverse health outcomes within the U.S. demographic aged 20–49. The information used for this study was sourced from the National Health and Nutrition Examination Survey (NHANES), carried out from 2001 to 2004. Logistic regression modeling was employed to calculate odds ratios and confidence intervals. The Wilcoxon rank-sum test was employed to assess differences in means, whereas the chi-square test, accompanied by Cramer’s V statistic, was used to examine the association among categorical variables. Additionally, the relationship between continuous variables was analyzed using Pearson’s correlation coefficient. Our association tests show that the length of occupation activity and health status were among the strongest associations to CSI risk. Based on our logistic regression models, age and sex were found to be significant factors in determining AL. We also found that age, smoking, and longest occupation activity were significant factors of CSI risk. These findings suggest a need for individuals to limit smoking as it may lead to higher overall stress despite its common use as a coping mechanism for stress. We should also review the level of occupational activity a job has before continuously working on it as this may also lead to higher cumulative stress.

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“…Human exposure to PFAS can occur in occupational settings [ 6 ] via cutaneous contact and inhalation. Non–occupational sources such as contaminated drinking water, and seafood (especially fish), are additional sources of exposure.…”

Section: Introductionmentioning

confidence: 99%

The Association of Per- and Polyfluoroalkyl Substances Serum Levels and Allostatic Load by Country of Birth and the Length of Time in the United States

Bashir

Asiseh

Jefferson-Moore

et al. 2022

IJERPH

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Objectives: The aim of this study was to examine the association of per– and polyfluoroalkyl (PFAS) concentrations and allostatic load (AL) by the county of birth and the length of time in the United States of America (U.S.), in a representative sample of U.S. adults. Methods: Data from the 2007–2014 National Health and Nutrition Examination Survey (NHANES) were used in this cross-sectional study on the U.S. adults aged 20 and older. The analysis was stratified by the length of time in the U.S. and by the county of birth. In all, the sample contained those who were US-born (n = 10,264), Mexico-born (n = 4018), other Spanish speaking country-born (n = 2989), and other not–Hispanic speaking country-born (n = 3911). Poisson models were used to assess the differences in AL and PFAS levels depending on country of birth and length of time in the U.S. Results: Estimates indicated that those born in Other non–Spanish speaking counties had the highest PFAS levels among the country of birth category in the database. Regarding length of time in the U.S., those born in Mexico had low PFAS levels when their length of time in the U.S. was short. The Mexico-born category presented the most at-risk high serum PFAS levels, with AL levels increasing by length of time in the U.S. (p-value < 0.001). Conclusion: This study found that PFAS concentrations increased by the length of time residing in the U.S. Those born in other non–Hispanic counties had the highest PFAS levels among all the categories. In general, AL and PFAS levels are mostly associated with the length of time in the U.S., with foreign-born individuals having increased levels of both the longer they stay.

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Interaction of Per- and Polyfluoroalkyl Substances and Allostatic Load among Adults in Various Occupations

Cited by 4 publications

References 34 publications

Transient Kinetics of Short-Chain Perfluoroalkyl Sulfonate with Radiolytic Reducing Species

Transient Kinetics of Short-Chain Perfluoroalkyl Sulfonate with Radiolytic Reducing Species

Chronic Stress Indicator: A Novel Tool for Comprehensive Stress Analysis

The Association of Per- and Polyfluoroalkyl Substances Serum Levels and Allostatic Load by Country of Birth and the Length of Time in the United States

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