2005
DOI: 10.1111/j.1440-1681.2005.04191.x
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Interaction of Physiological Mechanisms in Control of Muscle Glucose Uptake

Abstract: 1. Control of glucose uptake is distributed between three steps. These are the rate that glucose is delivered to cells, the rate of transport into cells, and the rate that glucose is phosphorylated within these same cells. The functional limitations to each one of these individual steps has been difficult to assess because they are so closely coupled to each other. Studies have been performed in recent years using complex isotopic techniques or transgenic mouse models to shed new light on the role that each st… Show more

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Cited by 47 publications
(49 citation statements)
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References 97 publications
(114 reference statements)
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“…A large proportion of diet-derived glucose is taken up by skeletal muscle in response to insulin, and excess glucose is stored in muscle as glycogen until mobilized (1). In addition, muscle burns large amounts of fat via mitochondrial ␤-oxidation in response to energy demands (2).…”
mentioning
confidence: 99%
“…A large proportion of diet-derived glucose is taken up by skeletal muscle in response to insulin, and excess glucose is stored in muscle as glycogen until mobilized (1). In addition, muscle burns large amounts of fat via mitochondrial ␤-oxidation in response to energy demands (2).…”
mentioning
confidence: 99%
“…Thus, hyperemia that occurs during exercise to increase delivery of glucose and other nutrients to muscles, may be an effective way to transport glucose for the people with compromised insulin mediated glucose uptake. In addition, exercise and insulin stimulation both increase the capacity for glucose phosphorylation (Wasserman & Ayala, 2005). In insulin resistant individuals, skeletal muscle hexokinase activity was reduced, but exercise can increase the capacity for glucose phosphorylation (Braithwaite, Palazuk, Colca, Edwards, & Hofmann, 1995;Vestergaard et al, 1995).…”
Section: Exercise/high Physical Activity Reduces Insulin Resistance: mentioning
confidence: 99%
“…Movement of glucose from the blood stream into cells in the body is determined by muscle blood flow, capillary recruitment, and endothelial permeability to glucose (Wasserman & Ayala, 2005). The number and activity of membrane glucose transporters determine the capacity for transporting glucose from interstitial to intracellular space.…”
Section: Exercise/high Physical Activity Reduces Insulin Resistance: mentioning
confidence: 99%
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