Interaction of polyamidoamine (PAMAM) succinamic acid dendrimers generation 4 with human serum albumin

Sękowski, Szymon; Buczkowski, Adam; Pałecz, Bartłomiej; Gabryelak, Teresa

doi:10.1016/j.saa.2011.07.009

Cited by 24 publications

(10 citation statements)

References 24 publications

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“…Deconvolution of CD spectra showed only minor changes in the secondary structure of HSA when influenced by the analyzed dendrimer. These changes may be regarded as almost insignificant, when compared to recently reported influence of the G4 PAMAM-NH 2 dendrimer 11 or G4 PAMAM-SAH (G4 PAMAM-NH 2 dendrimers with succinic acid residues attached to the surface amine groups) 12 on the CD spectrum and secondary structure of HSA. The conclusion about weaker interaction of the G4 PAMAM-pyrrolidone dendrimer with HSA, in comparison to the interaction of a G4 PAMAM-NH 2 dendrimer, is supported by the value of the binding constant estimated from the study of fluorescence quenching with the dendrimer.…”

Section: Discussionmentioning

confidence: 68%

Surface modification of PAMAM dendrimer improves its biocompatibility

Ciolkowski

Petersen

Ficker

et al. 2012

Nanomedicine: Nanotechnology, Biology and Medicine

110

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Section: Discussionmentioning

confidence: 68%

Surface modification of PAMAM dendrimer improves its biocompatibility

Ciolkowski

Petersen

Ficker

et al. 2012

Nanomedicine: Nanotechnology, Biology and Medicine

110

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“…If this occurs, it may be easily deduced that such interactions of dendrimers with proteins could be a factor that limits their use in medicine. For instance, PAMAM dendrimers have been recently shown to form complexes with proteins as well as to change the secondary structures of protein molecules [96]. PAMAM G4 dendrimers have also been shown to induce conformational changes and alter the electrostatic nature of bovine serum albumin (BSA) [49], an observation consistent with those of other studies that suggest the existence of strong dendrimer-protein interactions that are even likely to induce partial protein unfolding at high dendrimer concentrations [97].…”

Section: Pamams As Scavengers Of Excessive Glucose In Experimentalmentioning

confidence: 99%

The Janus Face of PAMAM Dendrimers Used to Potentially Cure Nonenzymatic Modifications of Biomacromolecules in Metabolic Disorders—A Critical Review of the Pros and Cons

et al. 2013

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Diabetes mellitus, which is characterised by high blood glucose levels and the burden of various macrovascular and microvascular complications, is a cause of much human suffering across the globe. While the use of exogenous insulin and other medications can control and sometimes prevent various diabetes-associated sequelae, numerous diabetic complications are still commonly encountered in diabetic patients. Therefore, there is a strong need for safe and effective antihyperglycaemic agents that provide an alternative or compounding option for the treatment of diabetes. In recent years, amino-terminated poly(amido)amine (PAMAM) dendrimers (G2, G3 and G4) have attracted attention due to their protective value as anti-glycation and anti-carbonylation agents that can be used to limit the nonenzymatic modifications of biomacromolecules. The focus of this review is to present a detailed survey of our own data, as well as of the available literature regarding the toxicity, pharmacological properties and overall usefulness of PAMAM dendrimers. This presentation pays particular and primary attention to their therapeutic use in poorly controlled diabetes and its complications, but also in other conditions, such as Alzheimer's disease, in which such nonenzymatic modifications may OPEN ACCESSMolecules 2013, 18 13770 underlie the pathophysiological mechanisms. The impact of dendrimer administration on the overall survival of diabetic animals and on glycosylation, glycoxidation, the brain-blood barrier and cellular bioenergetics are demonstrated. Finally, we critically discuss the potential advantages and disadvantages accompanying the use of PAMAM dendrimers in the treatment of metabolic impairments that occur under conditions of chronic hyperglycaemia.

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“…PAMAM succinamic acid dendrimers, synthesized with the reaction of succinic anhydride molecules with amine-terminated PAMAM dendrimers, are full generation dendrimers with less polydispersity compared to half generation carboxylate terminated dendrimers. These types of dendrimers can be better candidates for the transport of pharmacologically active guest molecules as compared to standard half generations [ 12 ].…”

Section: Types Of Dendrimersmentioning

confidence: 99%

Developments in Treatment Methodologies Using Dendrimers for Infectious Diseases

Filipczak

Yalamarty

et al. 2021

Molecules

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Dendrimers comprise a specific group of macromolecules, which combine structural properties of both single molecules and long expanded polymers. The three-dimensional form of dendrimers and the extensive possibilities for use of additional substrates for their construction creates a multivalent potential and a wide possibility for medical, diagnostic and environmental purposes. Depending on their composition and structure, dendrimers have been of interest in many fields of science, ranging from chemistry, biotechnology to biochemical applications. These compounds have found wide application from the production of catalysts for their use as antibacterial, antifungal and antiviral agents. Of particular interest are peptide dendrimers as a medium for transport of therapeutic substances: synthetic vaccines against parasites, bacteria and viruses, contrast agents used in MRI, antibodies and genetic material. This review focuses on the description of the current classes of dendrimers, the methodology for their synthesis and briefly drawbacks of their properties and their use as potential therapies against infectious diseases.

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Interaction of polyamidoamine (PAMAM) succinamic acid dendrimers generation 4 with human serum albumin

Cited by 24 publications

References 24 publications

Surface modification of PAMAM dendrimer improves its biocompatibility

Surface modification of PAMAM dendrimer improves its biocompatibility

The Janus Face of PAMAM Dendrimers Used to Potentially Cure Nonenzymatic Modifications of Biomacromolecules in Metabolic Disorders—A Critical Review of the Pros and Cons

Developments in Treatment Methodologies Using Dendrimers for Infectious Diseases

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