Interaction of Povidone with Aromatic Compounds II: Evaluation of Ionic Strength, Buffer Concentration, Temperature, and pH by Factorial Analysis

Plaizier-Vercammen, Jacqueline; Nève, R.e. De

doi:10.1002/jps.2600701118

Cited by 17 publications

(6 citation statements)

References 17 publications

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“…PVP has more potential for forming complexes with drugs or other polymers which shows an influence on the solubility, dissolution, and stability of drugs or products [ 154 , 162 , 163 ]. The unique nature of PVP is the coexistence of hydrophilic and hydrophobic segments which allows complexation with a variety of compounds like low molecular weight substances and several polymers [ 164 , 165 ]. The binding mechanisms may include either of the interactions like hydrogen bonding, polar or hydrophobic attractive forces [ 166 ].…”

Section: Pharmaceutical and Other Applicationsmentioning

confidence: 99%

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Kurakula

Rao

2020

Journal of Drug Delivery Science and Technology

292

172

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Polyvinylpyrrolidone (PVP) is a water-soluble polymer obtained by polymerization of monomer N -vinylpyrrolidone. PVP is an inert, non-toxic, temperature-resistant, pH-stable, biocompatible, biodegradable polymer that helps to encapsulate and cater both hydrophilic and lipophilic drugs. These advantages enable PVP a versatile excipient in the formulation development of broad conventional to novel controlled delivery systems. PVP has tunable properties and can be used as a brace component for gene delivery, orthopedic implants, and tissue engineering applications. Based on different molecular weights and modified forms, PVP can lead to exceptional beneficial features with varying chemical properties. Graft copolymerization and other techniques assist PVP to conjugate with poorly soluble drugs that can inflate bioavailability and even introduces the desired swelling tract for their control or sustained release. The present review provides chemistry, mechanical, physicochemical properties, evaluation parameters, dewy preparation methods of PVP derivatives intended for designing conventional to controlled systems for drug, gene, and cosmetic delivery. The past and growing interest in PVP establishes it as a promising polymer to enhance the trait and performance of current generation pharmaceutical dosage forms. Furthermore, the scrutiny explores existing patents, marketed products, new and futuristic approaches of PVP that have been identified and scope for future development, characterization, and its use. The exploration spotlights the importance and role of PVP in the design of Povidone-iodine (PVP–I) and clinical trials to assess therapeutic efficacy against the COVID-19 in the current pandemic scenario.

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Section: Pharmaceutical and Other Applicationsmentioning

confidence: 99%

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Kurakula

Rao

2020

Journal of Drug Delivery Science and Technology

292

172

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“…Plaizier-Vercammen and De Neve [9][10][11] showed there was an interaction between PVP with some aromatic compounds, such as benzoic acid and its derivatives in aqueous solutions using equilibrium dialysis and ultrafiltration. Therefore, because there was no influence of PVP on the passage of theophylline compared with acetaminophen, the results of this part of the study suggest that there is a potential for bonding between PVP and acetaminophen.…”

Section: Acetaminophen and Polyvinylpyrrolidone 175mentioning

confidence: 99%

Increasing the Aqueous Solubility of Acetaminophen in the Presence of Polyvinylpyrrolidone and Investigation of the Mechanisms Involved

Garekani

Sadeghi

Ghazi

2003

Drug Development and Industrial Pharmacy

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It was shown that the aqueous solubility of acetaminophen in the presence of polyvinylpyrrolidone (PVP) increased. The solubility at 25 degrees C increased from 14.3 m mL(-1) in the absence of PVP, to 19.7 mg m(-1) in the presence of 4% w/v PVP, and to 26.7mg mL(-1) in the presence of 8% w/v PVP. Dialysis studies indicated that there is a potential of binding between PVP and acetaminophen in their aqueous solutions. Dialysis studies also revealed that the nature of interaction between PVP and acetaminophen is physical and reversible, and there was no strong binding between PVP and acetaminophen in their solutions. Infrared spectroscopy of acetaminophen/PVP solid dispersion indicated that the mechanism of interaction between PVP and acetaminophen is via hydrogen bonding. Therefore, the increase in solubility of acetaminophen in the presence of PVP is probably attributed to its ability to form a water-soluble complex with PVP.

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“…The influence of polymer viscosity grade was tested by preparing complexes between diltiazem and 2 grades of carrageenan. Factorial analysis was used to evaluate, the influence of individual variables and their interactions [ 10,11]. Dissolution media at 3 different pH values were used: pH of 1.2, pH of 6.8, and pH of 8.2; the last value was chosen because it is above the diltiazem pKa of 7.7).…”

Section: Introductionmentioning

confidence: 99%

Factorial analysis of the influence of dissolution medium on drug release from carrageenan-diltiazem complexes

Bonferoni¹,

Rossi²,

Ferrari³

et al. 2000

AAPS PharmSciTech

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This research studied the influence of buffer composition, pH, and ionic strength on the release of diltiazem hydrochloride from a complex of the drug with lambda carrageenan. Two viscosity grades of carrageenan were also compared. A factorial analysis was used to evaluate the influence of individual variables and their interactions. Both the complex solubility, measured as the drug concentration in equilibrium with the solid complex, and the drug release rate from constant surface area were considered. The increase of ionic strength significantly increased complex solubility in all the buffer systems. A significant effect of polymer grade on complex solubility was evidenced only in phosphate buffer with a pH of 6.8, indicating lower solubility of the complex when higher polymer molecular weight was involved. In most cases, drug release rate decreased when high polymer grade was involved in the complex. Ionic strength did not always have a significant effect on drug release rate and was quantitatively less important than for solubility. Ionic strength especially affected the drug release profiles. At higher ionic strength drug release was no longer constant, but decreased with time, probably because of lower polymer solubility.

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Interaction of Povidone with Aromatic Compounds II: Evaluation of Ionic Strength, Buffer Concentration, Temperature, and pH by Factorial Analysis

Cited by 17 publications

References 17 publications

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Increasing the Aqueous Solubility of Acetaminophen in the Presence of Polyvinylpyrrolidone and Investigation of the Mechanisms Involved

Factorial analysis of the influence of dissolution medium on drug release from carrageenan-diltiazem complexes

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