Interaction of psychotropic drugs with monoamine oxidase in rat brain

Gnerre, Carmela; Kosel, Markus; Baumann, Pierre; Carrupt, Pierre‐Alain; Testa, Bernard

doi:10.1211/0022357011776513

Cited by 13 publications

(7 citation statements)

References 22 publications

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“…Competitive inhibition of MAO-A and noncompetitive inhibition of MAO-B was found for these drugs. Similar results were obtained when different tricyclic antidepressants and SSRIs were examined with isolated rat brain mitochondria [198]. Fluoxetine and norfluoxetine showed affinities both for MAO-A [199] and MAO-B [200].…”

Section: Inhibition Of Maosupporting

confidence: 79%

Mitochondrial Functions in Mood Disorders

Hroudová¹,

Fišar²,

Raboch³

2013

Mood Disorders

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Section: Inhibition Of Maosupporting

confidence: 79%

Mitochondrial Functions in Mood Disorders

Hroudová¹,

Fišar²,

Raboch³

2013

Mood Disorders

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“…Though a number of chemical compounds have been demonstrated as potent inhibitors of MAO activity in invertebrate tissues (Pan et al, 2000; Lee et al, 2001; Gnerre et al, 2001), there have not been many studies on mono amine oxidase activity under Pb‐intoxication. In the present study, a decrease in MAO activity was significant in mitochondria of cerebral cortex, hippocampus and cerebellum of 1% Pb‐treated rats, whereas a marginal increase in MAO activity was observed in 0.2% Pb‐treated rats.…”

Section: Discussionmentioning

confidence: 99%

Developmental lead exposure alters mitochondrial monoamine oxidase and synaptosomal catecholamine levels in rat brain

Devi

Reddy

Prasanthi

et al. 2005

Intl J of Devlp Neuroscience

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Rats were lactationally exposed to low- (0.2%) and high-level (1%) lead (Pb) from postnatal day 1 (PND1) through PND21 through the drinking water of the mother. The levels of catecholamines, epinephrine, norepinephrine and dopamine and the activity of the enzyme monoamine oxidase (MAO) were determined in the cerebellum, hippocampus and cerebral cortex in young (1-month-old) and adult (3-month-old) rats. Pb-exposure decreased the activity of mitochondrial MAO in all the brain regions in a dose-dependent manner. The synaptosomal catecholamines (epinephrine, norepinephrine and dopamine), however, increased with low level (0.2%) Pb-exposure and significantly decreased with high level (1%) Pb-exposure in both the age groups. In general, the young rats seem to be more vulnerable to Pb-neurotoxicity. These data suggest that Pb-exposure perturbs the aminergic system in the cerebral cortex, cerebellum and hippocampus and may contribute to the cognitive and behavioural impairments observed in Pb-exposed rats.

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“…190−193 The three SSRIs fluoxetine, fluvoxamine, and citalopram, for instance, demonstrated a competitive inhibitory activity toward rat brain MAO in the micromolar range. 190 In an in vitro study with Xenopus laevis oocytes expressing cloned rat 5-HT 2C receptors, Ni and Miledi 191 observed that micromolar concentrations of fluoxetine blocked the responses of these receptor previously elicited by 5-HT. Using the same model system, fluoxetine was also shown to block both muscle and neuronal nicotinic acetycholine receptors (nAChR) in a noncompetitive and voltagedependent manner.…”

Section: Past and Current Efforts To Detect Ecotoxicological Effects mentioning

confidence: 99%

Physiological Endpoints for Potential SSRI Interactions in Fish

Kreke

Dietrich

2008

Critical Reviews in Toxicology

115

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Selective serotonin reuptake inhibitors (SSRIs) are among the pharmaceutical compounds frequently detected in sewage treatment plant effluents and surface waters, albeit at very low concentrations, and have therefore become a focus of interest as environmental pollutants. These neuroactive drugs are primarily used in the treatment of depression but have also found broader use as medication for other neurological dysfunctions, consequently resulting in a steady increase of prescriptions worldwide. SSRIs, via inhibition of the serotonin (5-hydroxytryptamine, 5-HT) reuptake mechanism, induce an increase in extracellular 5-HT concentration within the central nervous system of mammals. The phylogenetically ancient and highly conserved neurotransmitter and neurohormone 5-HT has been found in invertebrates and vertebrates, although its specific physiological role and mode of action is unknown for many species. Consequently, it is difficult to assess the impact of chronic SSRI exposure in the environment, especially in the aquatic ecosystem. In view of this, the current knowledge of the functions of 5-HT in fish physiology is reviewed and, via comparison to the physiological role and function of 5-HT in mammals, a characterization of the potential impact of chronic SSRI exposure on fish is provided. Moreover, the insight on the physiological function of 5-HT strongly suggests that the experimental approaches currently used are inadequate if not entirely improper for routine environmental risk assessment of pharmaceuticals (e.g., SSRIs), as relevant endpoints are not assessed or impossible to determine.

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Interaction of psychotropic drugs with monoamine oxidase in rat brain

Cited by 13 publications

References 22 publications

Mitochondrial Functions in Mood Disorders

Mitochondrial Functions in Mood Disorders

Developmental lead exposure alters mitochondrial monoamine oxidase and synaptosomal catecholamine levels in rat brain

Physiological Endpoints for Potential SSRI Interactions in Fish

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