Interaction of Rifampin and Glucocorticoids

Buffington, Gary A.

doi:10.1001/jama.1976.03270180034016

Cited by 81 publications

(2 citation statements)

References 6 publications

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“…Other case reports of harm occurring due to loss of steroid efficacy with rifampin range in diseases such as nephrotic syndrome, giant cell arteritis, immunosuppression for renal transplant, and asthma [ 47 – 50 ]. A pharmacokinetic study of two patients with giant cell arteritis treated with prednisone and rifampin found that prednisolone clearance increased by greater than 200% and half-life decreased by 40% to 60% compared to prednisolone administration without rifampin.…”

Section: Anti-fungal Agentsmentioning

confidence: 99%

Pharmacokinetic Drug–Drug Interactions Between Immunosuppressant and Anti-Infective Agents: Antimetabolites and Corticosteroids

Matre

Satyanarayana²,

Page

et al. 2018

Ann Transplant

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Infections account for 15–20% of deaths in transplant recipients, requiring rapid and appropriate therapeutic interventions. Many anti-infective agents interact with immunosuppressive regimens used in transplantation, placing patients at increased risk for adverse drug reactions and prolonged hospitalizations. There is established data regarding the level of evidence and magnitude of interactions between calcineurin inhibitors and mammalian target of rapamycin inhibitors with anti-infective agents. Less is known about the interactions with anti-proliferative agents and corticosteroids, with gaps in knowledge on the appropriate management of these interactions. The objective of this review was to highlight the pharmacokinetic drug–drug interactions between antimetabolites and corticosteroids with commonly used anti-infective agents.

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Section: Anti-fungal Agentsmentioning

confidence: 99%

Pharmacokinetic Drug–Drug Interactions Between Immunosuppressant and Anti-Infective Agents: Antimetabolites and Corticosteroids

Matre

Satyanarayana²,

Page

et al. 2018

Ann Transplant

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“…For example; it is recommended that the dose of corticosteroids be doubled in some instances. 46 It is reported that prophylaxis of Pneumocystis carinii pneumonia with dapsone failed because of the interaction with rifampicin47 and serum levels of phenytoin, and the clinical effectiveness of warfarin and the oral contraceptive are reduced.4849 Rifampicin increases the rate of metabolism of many opiates including methadone and withdrawal symptoms may be induced. 50 In one prospective study, rifampicin, and to a lesser extent rifabutin, were shown to significantly reduce the mean serum levels of clarithromycin.51 This has raised doubts as to the effectiveness of this combination for the treatment of MAI and further studies are required.…”

Section: Pharmacokinetic Interactionsmentioning

confidence: 99%

Adverse effects and drug interactions of medications commonly used in the treatment of adult HIV positive patients.

Heylen

Miller²

1996

Sexually Transmitted Infections

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Tuberculosis in patients undergoing maintenance haemodialysis and renal transplantation

McWhinney

Khan

Williams

1981

Journal of British Surgery

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The difficulty in diagnosis of tuberculosis in patients with chronic renal failure or on immunosuppressive therapy is discussed. Anti-tuberculous therapy was required in 19 out of 315 patients who received a renal transplant in the Urology Unit, Hammersmith Hospital, between February 1961 and December 1979. Twelve patients were from overseas. Their management and the effect of anti-tuberculous therapy on the immunosuppressed patient were also studied. The disease was treated successfully in 18 patients, even though there were problems with diagnosis. The patient who died had active tuberculosis on post-morten examination. Prophylaxis should be considered in patients who have had tuberculosis in the past and may have received inadequate treatment.

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Interaction of Rifampin and Glucocorticoids

Cited by 81 publications

References 6 publications

Pharmacokinetic Drug–Drug Interactions Between Immunosuppressant and Anti-Infective Agents: Antimetabolites and Corticosteroids

Pharmacokinetic Drug–Drug Interactions Between Immunosuppressant and Anti-Infective Agents: Antimetabolites and Corticosteroids

Adverse effects and drug interactions of medications commonly used in the treatment of adult HIV positive patients.

Tuberculosis in patients undergoing maintenance haemodialysis and renal transplantation

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