Interaction of Some Selected Trace Elements with Thyroid Hormones in Patients with Goiter in Ibadan, Nigeria

Adedapo, Kayode Solomon; Sonuga, Ayobola Abimbola; Afolabi, Adefemi; Amosu, A M

doi:10.9734/jsrr/2014/11985

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…In addition to this, the tubular excretion of Zn also leads to low levels of plasma zinc [31]. Copper is an essential element, acts as a cofactor for tyrosinase which is required for the biosynthesis of tyrosine; a protein component of thyroglobulin needed for the synthesis of the thyroid hormones [32]. In the present study, we revealed the significantly decreased level of copper in patients with hypothyroidism as compared to controls which is consistent with the previous studies [27,28].…”

Section: Discussionmentioning

confidence: 99%

Study of Trace Elements in Patients of Hypothyroidism with Special Reference to Zinc and Copper

Arora¹,

Mahat

Kumar³

et al. 2018

BJSTR

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Background: Hypothyroidism is a clinical entity resulting from a deficiency of thyroid hormones or, more rarely, from their impaired activity at the tissue level. Several mineral and trace elements are essential for normal thyroid hormone metabolism and co-existing deficiencies of these elements can impair thyroid function. The present study was conducted with the aim to find out the concentrations of zinc and copper in hypothyroidism and to determine the possible correlations between trace elements and thyroid hormones. Material and Methods:Our study included 40 patients with hypothyroidism and 40 normal control subjects. In all the subjects, T3, T4, and TSH were measured by ELISA whereas trace elements zinc and copper were measured colorimetrically.Results: Both zinc and copper were significantly reduced in patients of hypothyroidism as compared to controls (57.05±7.54 µg/dl vs. 98.02±7.77 µg/dl, p<0.001 and 73.86±6.22 µg/dl vs. 114.97±18.18 µg/dl, p<0.001, respectively). Zinc was significantly and positively correlated with T3 (r=0.326; p<0.05) in hypothyroidism patients but there was no significant correlation of zinc with rest of the hormones i.e, T4 (r=0.078; p>0.05) and TSH (r=-0.026; p>0.05) levels. With regard to copper, we did not find any significant correlation of copper with T3 (r=0.076; p>0.05), T4 (r=0.171; p>0.05) and TSH (r=0.167; p>0.05). Conclusion:In conclusion, hypothyroid patients had significantly decreased concentration of zinc and copper. Hence, diet rich in trace elements, viz. zinc and copper should be supplied to patients of hypothyroidism in order to maintain normal thyroid hormone function.

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Section: Discussionmentioning

confidence: 99%

Study of Trace Elements in Patients of Hypothyroidism with Special Reference to Zinc and Copper

Arora¹,

Mahat

Kumar³

et al. 2018

BJSTR

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“…11 Ayrıca, T4 üretimini uyarmakta ve vücudun kalsiyum seviyelerini kontrol ederek kan hücrelerinde aşırı T4 emilimini önlemektedir. 12 Vücutta birçok enzimin yapısında bulunan demir O2 ve elektron transportunda rol oynayan çeşitli önemli fonksiyonel proteinlerin ana bileşenidir. 3,4 Dokularda Fe geri emiliminin düzenlenmesi ve Fe homeostazında T4 düzeyi önemlidir.…”

Section: Introductionunclassified

Hashimoto Tiroiditli Hastalarda Bakır, Demir, Çinko, Selenyum Düzeyleri ve Cu/Se, Cu/Zn, Fe/Se, Fe/Zn Oranlarının Araştırılması

Cinemre¹,

Bahtiyar²,

Ertan³

et al. 2018

Sakarya Medical Journal

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Study of copper and ceruloplasmin in hypothyroidism and Grave’s hyperthyroidism as compared to euthyroidism: Hospital-based case–control study

Bhat,

Patra,

Raju

et al. 2023

MRIMS Journal of Health Sciences

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Background: Hypothyroidism was highly prevalent in India, with 10.95% affected patients as compared with only 2% in the United Kingdom and 4·6% in the USA. The prevalence of Hyperthyroidism was found to be 1.6%. Copper has an essential role in thyroid metabolism, thyroid hormone production, and absorption. Copper is an essential part of thyroxine (T4) hormone and thyroid-stimulating hormone (TSH) synthesis. Objectives: This study evaluated the status of serum copper and ceruloplasmin levels in hypothyroidism and Grave’s hyperthyroidism in comparison with euthyroid participants. Materials and Methods: This was a hospital-based case–control study that involved 100 cases of hypothyroidism and 60 cases of Grave’s hyperthyroidism compared with 100 euthyroid participants aged 15–60 years. After detailed case history and examination, the blood sample was collected and analyzed the same day for FreeT3, FreeT4, TSH, serum copper, and ceruloplasmin levels. Results: Compared to euthyroid participants, patients with clinical hypothyroidism had statistically significant (P < 0.05) lower levels of serum copper and ceruloplasmin. The scenario was the opposite in the case of Grave’s hyperthyroidism patients. Our study found statistically significant (P < 0.05) higher serum copper and ceruloplasmin levels in Grave’s hyperthyroidism patients. Conclusion: Our study found serum copper levels directly affected the thyroid profile and vice versa. The deficiency of one parameter affected the other. Patients with hypothyroidism and hyperthyroidism should be routinely screened for serum copper and ceruloplasmin levels for more effective thyroid treatment.

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Interaction of Some Selected Trace Elements with Thyroid Hormones in Patients with Goiter in Ibadan, Nigeria

Cited by 3 publications

References 18 publications

Study of Trace Elements in Patients of Hypothyroidism with Special Reference to Zinc and Copper

Study of Trace Elements in Patients of Hypothyroidism with Special Reference to Zinc and Copper

Hashimoto Tiroiditli Hastalarda Bakır, Demir, Çinko, Selenyum Düzeyleri ve Cu/Se, Cu/Zn, Fe/Se, Fe/Zn Oranlarının Araştırılması

Study of copper and ceruloplasmin in hypothyroidism and Grave’s hyperthyroidism as compared to euthyroidism: Hospital-based case–control study

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