Interaction of tamoxifen with concurrent cytotoxic adjuvant treatment affects lymphocytes and lymphocyte subsets counts in breast cancer patients

Sabbioni, Marzio; Castiglione, M.; Hürny, Christoph; Siegrist, H P; Bacchi, M.; Bernhard, Jürg; Thürlimann, Beat; Bonnefoi, Hervé; Perey, L; Goldhirsch, Aron; Senn, Hans

doi:10.1007/s005200050245

Cited by 11 publications

(6 citation statements)

References 19 publications

(19 reference statements)

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“…Fludarabine, a nucleoside drug used in hematologic cancers, produces a profound and persistent depletion in T cell (CD4+) populations 20, 21. Furthermore, Stages I and II breast carcinoma survivors who received cyclic chemotherapy (CMF‐cyclophosphamide, methotrexate, and 5‐fluorouracil) have been shown to depress total lymphocyte counts as well as decrease T cells (CD4+, CD8+), B cells (CD19+), NK cells (CD3–CD16+CD56+), and activated T cells 22. Similarly, Sewell et al showed that breast carcinoma survivors who received cyclic CMF had decreased numbers of T cells (CD4+) and B cells (CD19+), as well as reduced functional capacity in NK cells and lymphokine‐activated killer (LAK) cells that persisted for up to six months following cessation of therapy 23…”

Section: Immune System Response To Tumorsmentioning

confidence: 99%

Physical exercise and immune system function in cancer survivors

Fairey

Courneya

Field

et al. 2002

Cancer

141

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BACKGROUNDThere are a limited number of interventions for cancer survivors following completion of primary therapy that might reduce the risk of cancer recurrence and/or secondary malignancies and increase survival times. It has been proposed that physical exercise may be beneficial by enhancing the anticancer immune system response. The purpose of the current article is to: 1) briefly describe the immune system response to tumors, 2) discuss the impact of anticancer therapy on immune system function in cancer survivors, 3) provide a systematic and comprehensive review of the extant literature examining physical exercise and immune system function in cancer survivors, and 4) offer a critical analysis of this literature and outline directions for future research.METHODSA comprehensive literature search up to March 2001 identified empirical articles that examined the effects of physical exercise training on immune system function in cancer survivors from CD‐ROM database searches and manual searches.RESULTSTo the authors' knowledge, six empirical studies published between 1994 and 2000 have examined physical exercise and immune system function in cancer survivors. Overall, four out of six studies reported statistically significant improvements in a number of cancer‐related immune system components as a result of exercise. However, there are several limitations that must be considered when interpreting the findings of these studies. These limitations involve the samples, designs, physical exercise interventions, physical fitness assessments, and immunologic assessments.CONCLUSIONSAdditional research is needed to determine if physical exercise in cancer survivors may reduce the risk of cancer recurrence and secondary malignancies and increase survival times. Cancer 2002;94:539–51. © 2002 American Cancer Society.

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Section: Immune System Response To Tumorsmentioning

confidence: 99%

Physical exercise and immune system function in cancer survivors

Fairey

Courneya

Field

et al. 2002

Cancer

141

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“…These studies indicate that each chemotherapy regimen has a different effect on immunological parameters [9][10][11]. The results of studies on patients, however, cannot be extrapolated to occupational exposures.…”

Section: Introductionmentioning

confidence: 99%

Immunotoxicity Monitoring of Hospital Staff Occupationally Exposed to Cytostatic Drugs

Bíró¹,

Fodor²,

Major³

et al. 2010

Pathol. Oncol. Res.

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The aim of our study was to investigate the immunotoxicity of occupational cytostatic drug exposure, and to assess the possible effect of confounding factors, such as age and smoking. In this human study, the immunotoxic effect of antineoplastic drugs was investigated among 306 nurses working in oncology chemotherapy units. Results were compared to 98 non-exposed women. The immune status of the subjects was characterized by immune phenotyping of peripheral blood lymphocytes by flow cytometry, using monoclonal antibodies against surface antigens (CD3, CD4, CD8, CD19, CD25, CD45, CD56 and CD71). The killing ability of neutrophil leukocytes was assessed by the measurement of reactive oxygen intermediate production. Occupational exposure to antineoplastic drugs caused shifts in the major lymphocyte subpopulations, resulting in a statistically significant increase in the ratio of B cells. Cytostatic drug exposure also manifested itself in a decreased frequency of CD25 positive, activated T lymphocytes, and increased oxidative burst of neutrophil granulocytes, both of which may have a functional impact on the immune system of exposed subjects. In the younger subjects exposure also caused a shift in T cell subpopulations: a reduction in the cytotoxic T cell population lead to an elevated Th/Tc ratio. In the exposed group, smoking increased activation of T lymphocyte subpopulations. In conclusion, we have demonstrated that low dose occupational cytostatic drug exposure is immunotoxic, and age and smoking modify the effect of exposure.

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“…For example, lymphocyte depletion in human patients undergoing chemotherapy has been reported, but the degree of lymphocyte depletion appeared to be dependent on the particular chemotherapy protocol. [1][2][3][4] Lymphocyte depletion, specifically, depletion of CD4 + T cells, may persist long after completion of chemotherapy. 5,6 Not all chemotherapy agents are equally immunosuppressive.…”

mentioning

confidence: 99%

Effects of Chemotherapy on Immune Responses in Dogs with Cancer

Walter

Biller

Lana

et al. 2006

Veterinary Internal Medicne

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Chemotherapy is assumed to be immunosuppressive; yet to the authors' knowledge, the effects of common chemotherapy protocols on adaptive immune responses in dogs with cancer have not been fully evaluated. Therefore, a study was conducted to evaluate the effects of 2 common chemotherapy protocols on T- and B-cell numbers and humoral immune responses to de novo vaccination in dogs with cancer. Twenty-one dogs with cancer (12 with lymphoma, 9 with osteosarcoma) were enrolled in a prospective study to assess effects of doxorubicin versus multi-drug chemotherapy on adaptive immunity. Numbers of circulating T and B cells were assessed by flow cytometry, and antibody responses to de novo vaccination were assessed before, during, and after chemotherapy. The T- and B-cell numbers before treatment also were compared with those of healthy, age-matched, control dogs. Prior to treatment, dogs with cancer had significantly fewer (P < .05) CD4+ T cells and CD8+ T cells than did healthy dogs. Doxorubicin treatment did not cause a significant decrease in T- or B-cell numbers, whereas treatment with combination chemotherapy caused a significant and persistent decrease in B-cell numbers. Antibody titers after vaccination were not significantly different between control and chemotherapy-treated dogs. These findings suggest that chemotherapy may have less impact on T-cell numbers and ability to mount antibody responses in dogs with cancer than was previously anticipated, though dogs with lymphoma or osteosarcoma appear to be relatively T-cell deficient before initiation of chemotherapy.

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Interaction of tamoxifen with concurrent cytotoxic adjuvant treatment affects lymphocytes and lymphocyte subsets counts in breast cancer patients

Cited by 11 publications

References 19 publications

Physical exercise and immune system function in cancer survivors

Physical exercise and immune system function in cancer survivors

Immunotoxicity Monitoring of Hospital Staff Occupationally Exposed to Cytostatic Drugs

Effects of Chemotherapy on Immune Responses in Dogs with Cancer

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