2016
DOI: 10.1111/cmi.12609
|View full text |Cite
|
Sign up to set email alerts
|

Interaction of the Lyme disease spirochete with its tick vector

Abstract: Summary Borrelia burgdorferi , the causative agent of Lyme disease (along with closely related genospecies), is in the deeply branching spirochete phylum. The bacterium is maintained in nature in an enzootic cycle that involves transmission from a tick vector to a vertebrate host and acquisition from a vertebrate host to a tick vector. During its arthropod sojourn, B. burgdorferi faces a variety of stresses, including nutrient deprivation. Here, we review some of the spirochetal factors that promote persistenc… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
124
0

Year Published

2016
2016
2023
2023

Publication Types

Select...
6
2

Relationship

2
6

Authors

Journals

citations
Cited by 89 publications
(124 citation statements)
references
References 77 publications
(148 reference statements)
0
124
0
Order By: Relevance
“…2a). Notably, asRNAs were identified opposite to key genes active in the maintenance of the B. burgdorferi life cycle and cell division, such as: bb0420 ( hk1 ), bb0827 ( hrpA ), bbb03 ( resT ), bbb17 ( guaB ), and bba66 [4, 13, 4450]. Hk1 is the histidine kinase in the two-component system necessary for B. burgdorferi survival in the tick [45].…”
Section: Resultsmentioning
confidence: 99%
“…2a). Notably, asRNAs were identified opposite to key genes active in the maintenance of the B. burgdorferi life cycle and cell division, such as: bb0420 ( hk1 ), bb0827 ( hrpA ), bbb03 ( resT ), bbb17 ( guaB ), and bba66 [4, 13, 4450]. Hk1 is the histidine kinase in the two-component system necessary for B. burgdorferi survival in the tick [45].…”
Section: Resultsmentioning
confidence: 99%
“…Nymphs molt to adults that feed, mate, and lay eggs to continue the cycle (adapted from Caimano et al). 7 …”
Section: Figmentioning
confidence: 99%
“…1). 57 Ixodes larvae acquire B. burgdorferi by feeding on a mammalian host, and the spirochetes inhabit the midgut. The larvae molt and, when the resulting nymphs feed, the spirochetes leave the midgut, enter the hemocoel, migrate to the salivary glands, and transmit to the vertebrate source of the blood meal.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…As a tick-borne pathogen, Bb cycles between the Ixodes tick vector and mammals in its natural environment 10,16 . It is possible that Bb requires thiamin for its survival in vivo , but it lacks a role for it in vitro .…”
mentioning
confidence: 99%