Interaction of the natural anxiolytic Galphimine-B with serotonergic drugs on dorsal hippocampus in rats

Jiménez-Ferrer, Enrique; Herrera-Ruíz, Maribel; Ramírez-García, Raúl; Herrera-Arellano, Armando; Tortoriello, Jaime

doi:10.1016/j.jep.2011.06.029

Cited by 23 publications

(10 citation statements)

References 27 publications

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“…G-B is a nor-seco-triterpene compound, and its chemical name is (4R)-trihydroxy-13α-methoxycarbonyl-30-nor-3,4-seco-7α,18β-fridela-1,20-dien-3,24-olide. It has been determined that G-B acts by depressing selectively VTA dopaminergic neurons through a non-GABAergic presynaptic mechanism, as well as by interacting with the serotoninergic system in the dorsal hippocampus [21,22]. The anxiolytic activity of different doses of the G. glauca methanolic extract has been evidenced in behavioral models such as plus maze and light-dark, with results similar to those obtained with diazepam [23,24].…”

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confidence: 65%

Therapeutic Effectiveness of Galphimia glauca vs. Lorazepam in Generalized Anxiety Disorder. A Controlled 15-Week Clinical Trial

et al. 2012

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tolerability and safety. One hundred ninety-one patients initiated the study with 94 in the experimental group. One hundred four patients concluded the study, 51 of these in the experimental group. Anxiolytic effectiveness, measured as 0 in a negative case and as 1 in a positive case, was assessed 593 times in the experimental group and 631 in the control; the mean effectiveness observed was 0.686 ± 0.019 vs. 0.588 ± 0.019 (repeated-measures ANOVA; p = 0.0003). In the same way, G. glauca-herbal medicinal product diminished the score in the Hamilton anxiety scale to 11.51 ± 8.27 points and lorazepam to 12.40 ± 8.07 points (repeated-measures ANOVA; p = 0.05). The tolerability analysis, which comprised patients who concluded the treatment plus 11 patients who withdrew due to adverse reactions did not show differences between treatments (p = 0.35), nor did therapeutic safety demonstrate differences between groups (p = 0.21). There were no cases of tolerance, intoxication, dependence, or suppression syndrome. We concluded that G. glauca herbal medicinal product, standardized in 0.175 mg of galphimine-B and administered for 15 weeks to patients with generalized anxiety disorder, showed greater anxiolytic effectiveness than that obtained with lorazepam, with high percentages of therapeutic tolerability and safety.

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Therapeutic Effectiveness of Galphimia glauca vs. Lorazepam in Generalized Anxiety Disorder. A Controlled 15-Week Clinical Trial

et al. 2012

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“…In traditional Mexican and Central American cultures, the leaves and stem from galphimia are used for nervous disorders, with the serotonergic galphimine B being regarded as an active constituent (Jimenez‐Ferrer, Herrera‐Ruiz, Ramirez‐Garcia, Herrera‐Arellano, & Tortoriello, ). It has been shown to interact with serotonergic transmission via the dorsal hippocampus in rats, by increasing the frequency of neuronal discharge in CA1 cells, activating the 5HT(1A) receptors (Jimenez‐Ferrer et al, ). In a 4 week double‐blind RCT, an aqueous extract of galphimia was administered to 153 patients with a DSM‐IV diagnosis of GAD (Herrera‐Arellano et al, ).…”

Section: Anxiety Disordersmentioning

confidence: 99%

Herbal medicines in the treatment of psychiatric disorders: 10‐year updated review

Sarris

2018

Phytotherapy Research

142

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This paper provides a 10-year update of the 2007 systematic review of herbal medicines studied in a broad range of psychiatric disorders, including depression, anxiety, obsessive-compulsive, seasonal affective, bipolar, psychotic, phobic, somatoform, and attention-deficit hyperactivity disorders. Ovid Medline, PubMed, and the Cochrane Library were searched for herbal medicines with both pharmacological and clinical evidence of psychotropic activity. This updated review now covers clinical trial evidence for 24 herbal medicines in 11 psychiatric disorders. High-quality evidence was found to exist for the use of Piper methysticum (Kava), Passiflora spp. (passionflower) and Galphimia glauca (galphimia) for anxiety disorders; and Hypericum perforatum (St John's wort) and Crocus sativus (saffron) for major depressive disorder. Other encouraging herbal medicines with preliminary evidence include Curcuma longa (turmeric) in depression, Withania somnifera (ashwagandha) in affective disorders, and Ginkgo biloba (ginkgo) as an adjunctive treatment in Schizophrenia. Although depression and anxiety are commonly researched, many other mental disorders still require further prospective investigation. Although the previous review suggested increasing the adjunctive study of select herbal medicines with pharmaceuticals, this was still only found to sparingly occur in research designs. Aside from this, future focus should involve the incorporation of more biomarker analysis, in particular pharmacogenomics, to determine genetic factors moderating response to herbal medicines.

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“…In a further study, this effect was found to be caused by the presence of galphimine B [ 52 ]. Additionally, further analysis revealed that this nor-secotriterpene compound could be exerting this anxiolytic effect due to an inhibition in dopaminergic activity [ 7 , 41 ] along with possible interactions with the serotonergic system [ 53 ] ( Table 2 ).…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Multidisciplinary Investigations on Galphimia glauca: A Mexican Medicinal Plant with Pharmacological Potential

et al. 2018

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Galphimia glauca (Cav.) Kuntze is an important endemic plant species, which possesses many medicinal properties and has been used in the Mexican traditional medicine for its sedative, anxiolytic, anticonvulsant, antiasthmatic and antiallergic properties. The therapeutic properties of this plant are mainly due to the presence of diverse bioactive compounds such as flavonoids, triterpenoids, and phenolics. Several triterpenoids and flavonoids compounds have been isolated and identified. Modern studies have demonstrated many biological activities such as anti-inflammatory, antidiarrheal, gastroenteritis, antimalarial and cytotoxic activities. Nevertheless, many studies are restricted to the crude extract, and many bioactive compounds are yet to be identified and validated according to its traditional use. However, its commercial exploitation and use are highly limited due to the non-availability of enough plant material and lack of knowledge about its agronomical practices. Moreover, the misinterpretation and mislabeling of closely related species of the genus Galphimia Cav. as G. glauca or G. gracilis is a common problem for its rigorous scientific study and commercial exploitation. The present review provides comprehensive knowledge based on the available scientific literature. To the best of our knowledge, this is the first review on G. glauca. This comprehensive information will certainly provide a guide for the better understanding and utilization of G. glauca for its scientific and industrial exploitation.

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Interaction of the natural anxiolytic Galphimine-B with serotonergic drugs on dorsal hippocampus in rats

Cited by 23 publications

References 27 publications

Therapeutic Effectiveness of Galphimia glauca vs. Lorazepam in Generalized Anxiety Disorder. A Controlled 15-Week Clinical Trial

Therapeutic Effectiveness of Galphimia glauca vs. Lorazepam in Generalized Anxiety Disorder. A Controlled 15-Week Clinical Trial

Herbal medicines in the treatment of psychiatric disorders: 10‐year updated review

Multidisciplinary Investigations on Galphimia glauca: A Mexican Medicinal Plant with Pharmacological Potential

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