Interaction of total blood calcium levels and brain catecholamines during the formation and reinforcement of memory traces in hypoparathyroidism

Sashkov, V. A.; Джандарова, Т. И.; Сельверова, Н. Б.

doi:10.1007/s11055-007-0061-0

Cited by 1 publication

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“…Nkx2-1 may therefore act as an important calcium-sensing factor that responds to altered intracellular calcium levels in order to regulate the gene expression required to maintain calcium homeostasis (Suzuki et al, 1998b ). Animals with abnormal calcium homeostasis, after removal of the parathyroid gland, exhibit changes in basal dopamine and noradrenaline levels in limbic structures, abnormalities in conditioned reflex activity, and the acquisition of adaptive behavioral strategies (Sashkov et al, 2007 ).…”

Section: Calcium Homeostasis and Bone Cell Metabolismmentioning

confidence: 99%

A Role for the Transcription Factor Nk2 Homeobox 1 in Schizophrenia: Convergent Evidence from Animal and Human Studies

Malt

Naumann

2016

Front. Behav. Neurosci.

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Schizophrenia is a highly heritable disorder with diverse mental and somatic symptoms. The molecular mechanisms leading from genes to disease pathology in schizophrenia remain largely unknown. Genome-wide association studies (GWASs) have shown that common single-nucleotide polymorphisms associated with specific diseases are enriched in the recognition sequences of transcription factors that regulate physiological processes relevant to the disease. We have used a “bottom-up” approach and tracked a developmental trajectory from embryology to physiological processes and behavior and recognized that the transcription factor NK2 homeobox 1 (NKX2-1) possesses properties of particular interest for schizophrenia. NKX2-1 is selectively expressed from prenatal development to adulthood in the brain, thyroid gland, parathyroid gland, lungs, skin, and enteric ganglia, and has key functions at the interface of the brain, the endocrine-, and the immune system. In the developing brain, NKX2-1-expressing progenitor cells differentiate into distinct subclasses of forebrain GABAergic and cholinergic neurons, astrocytes, and oligodendrocytes. The transcription factor is highly expressed in mature limbic circuits related to context-dependent goal-directed patterns of behavior, social interaction and reproduction, fear responses, responses to light, and other homeostatic processes. It is essential for development and mature function of the thyroid gland and the respiratory system, and is involved in calcium metabolism and immune responses. NKX2-1 interacts with a number of genes identified as susceptibility genes for schizophrenia. We suggest that NKX2-1 may lie at the core of several dose dependent pathways that are dysregulated in schizophrenia. We correlate the symptoms seen in schizophrenia with the temporal and spatial activities of NKX2-1 in order to highlight promising future research areas.

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Section: Calcium Homeostasis and Bone Cell Metabolismmentioning

confidence: 99%