Interaction of Transresveratrol with Plasma Lipoproteins

Belguendouz, Leila; Frémont, Lucie; Gozzelino, Marie-Thérèse

doi:10.1016/s0006-2952(97)00544-3

Cited by 143 publications

(87 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3). Resveratrol has been shown to interact with protein kinase C, 10 aromatase, 11 hetero-dimeric alphaVbeta3 integrin, 12 multidrug resistance protein 1, 13 β-lactoglubulin, 14 human serum albumin, 15 human DNA topoisomerase II, 16 plasma lipoprotein, 17 nucleic acids, 18 DNA polymerase α and δ, 19 myeloperoxidase, 20 tubulin, 21 estrogen receptor α and β, 22 F1-ATPase, 23 sulfonyl urea receptors, 24 cytosolic alcohol dehydrogenase, 25 amyloid fibrils 26 and dihydronicotinamide riboside quinone reductase 2 (NQO2). 27 In most cases interaction of resveratrol with these proteins leads to inactivation of the molecule.…”

Section: Molecular Targets Of Resveratrolmentioning

confidence: 99%

Resveratrol: A multitargeted agent for age-associated chronic diseases

Harikumar¹,

Aggarwal²

2008

Cell Cycle

483

339

View full text Add to dashboard Cite

Extensive research within the last decade has revealed that most chronic illnesses such as cancer, cardiovascular and pulmonary diseases, neurological diseases, diabetes, and autoimmune diseases exhibit dysregulation of multiple cell signaling pathways that have been linked to inflammation. Thus mono-targeted therapies developed for the last two decades for these diseases have proven to be unsafe, ineffective and expensive. Although fruits and vegetables are regarded to have therapeutic potential against chronic illnesses, neither their active component nor the mechanism of action is well understood. Resveratrol (trans-3, 5, 4'-trihydroxystilbene), a component of grapes, berries, peanuts and other traditional medicines, is one such polyphenol that has been shown to mediate its effects through modulation of many different pathways. This stilbene has been shown to bind to numerous cell-signaling molecules such as multi drug resistance protein, topoisomerase II, aromatase, DNA polymerase, estrogen receptors, tubulin and F1-ATPase. Resveratrol has also been shown to activate various transcription factor (e.g., NFκB, STAT3, HIF-1α, β-catenin and PPAR-γ), suppress the expression of antiapoptotic gene products (e.g., Bcl-2, Bcl-X L , XIAP and survivin), inhibit protein kinases (e.g., src, PI3K, JNK and AKT), induce antioxidant enzymes (e.g., catalase, superoxide dismutase and hemoxygenase-1), suppress the expression of inflammatory biomarkers (e.g., TNF, COX-2, iNOS and CRP), inhibit the expression of angiogenic and metastatic gene products (e.g., MMPs, VEGF, cathepsin D and ICAM-1), and modulate cell cycle regulatory genes (e.g., p53, Rb, PTEN, cyclins and CDKs). Numerous animal studies have demonstrated that this polyphenol holds promise against numerous age-associated diseases including cancer, diabetes, Alzheimer, cardiovascular and pulmonary diseases. In view of these studies, resveratrol's prospects for use in the clinics are rapidly accelerating. Efforts are also underway to improve its activity in vivo through structural modification and reformulation. Our review describes various targets of resveratrol and their therapeutic potential.

show abstract

Section: Molecular Targets Of Resveratrolmentioning

confidence: 99%

Resveratrol: A multitargeted agent for age-associated chronic diseases

Harikumar¹,

Aggarwal²

2008

Cell Cycle

483

339

View full text Add to dashboard Cite

show abstract

“…Resveratrol has been shown to modulate lipoprotein metabolism, 13,14 eicosanoid synthesis, [15][16][17] oxidation, 18 and platelet aggregation. 15,19 Recently, resveratrol has also been demonstrated to inhibit cellular processes associated with tumor initiation, promotion, and progression.…”

mentioning

confidence: 99%

Resveratrol selectively inhibits leukemia cells: a prospective agent for ex vivo bone marrow purging

Dumaguin

et al. 2000

Bone Marrow Transplant

100

View full text Add to dashboard Cite

Summary:Ex vivo purging of contaminating tumor cells may reduce the incidence of relapse in patients undergoing bone marrow transplantation. In this study we demonstrate that resveratrol, a phytoalexin with anti-oxidant and chemopreventive activity, exhibits anti-leukemic activity against mouse (32Dp210, L1210) and human (U937, HL-60) leukemic cell lines by inhibiting cell proliferation. Long-term exposure to resveratrol also inhibits the clonal growth of normal hematopoietic progenitor cells but at a higher IC 50

show abstract

“…Lipophilic properties of RSV may improve its antioxidant activity (98,99). In order to increase the evidence demonstrating the involvement of free radicals in numerous disorders and diseases including cancer (100), cardio-vascular diseases and neurological disorders, ageing (16,101,102) and lipid peroxidation, RSV has received increased attention.…”

Section: Resveratrol As a Potent Antioxidantmentioning

confidence: 99%

Resveratrol (3,5,4′-trihydroxystilbene) and its properties in oral diseases

Perrone

Fuggetta

Ardito

et al. 2017

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Health promotion strategies and lifestyle changes are important in disease prevention. Oral health has received a large amount of attention previously as it is a fundamental component of general health and it contributes to the quality of life. Therefore, the study of associations between diet, health and the presence of bioactive compounds in food is receiving a substantial amount of attention. In the present review the effects and targets of a natural polyohenolic stilbenoid compound; resveratrol (3,5,4'-trihydroxystilbene; RSV) is assessed, and the future prospects for RSV in promoting oral health are considered. RSV is a phytoalexin, synthesized by a wide range of plants and abundantly extracted in grape skin, it has been purported to exert a multiplicity of anti-inflammatory, anti-viral, anti-microbial, estrogenic, anticancer, cardioprotective, neuroprotective and immunomodulatory functions. In this review, following an introduction documenting the biochemistry of RSV and RSV glucosides, the bioavailability and pharmacokinetics of RSV are described. Considering its multiple properties, the present review has focused on the potential benefits of RSV as an antioxidant and chemopreventive agent.

show abstract

Interaction of Transresveratrol with Plasma Lipoproteins

Cited by 143 publications

References 24 publications

Resveratrol: A multitargeted agent for age-associated chronic diseases

Resveratrol: A multitargeted agent for age-associated chronic diseases

Resveratrol selectively inhibits leukemia cells: a prospective agent for ex vivo bone marrow purging

Resveratrol (3,5,4′-trihydroxystilbene) and its properties in oral diseases

Contact Info

Product

Resources

About