Interaction of triflupromazine with distearoylphosphatidylglycerol films studied by surface pressure isotherms and cyclic voltammetry at a 1,2-dichloroethane/water interface

Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models

“…A change in the shape of the isotherm is evident, appearing as a plateau after the lift-off, corresponding to the liquid expanded–liquid condensed phase transition, at approximately 17 mN m −1 . Similar behavior was previously reported for HTFPZ + using DSPG monolayers [ 12 ]. For all curves, pure DSPA and 15, 55 and 96 mol% HTFPZ + :DSPA, the collapse pressure is similar.…”

“…The simplest model is a one-component monolayer, which, although a simplification, allows easy characterization of the process used to target a drug to the cell and its potential toxicity. In this context, many drugs with different chemical structures and pharmacological effects have been investigated, such as antimicrobial [ 2 , 3 ], antitumoral [ 4 , 5 ], anti-inflammatory [ 6 , 7 , 8 , 9 ], anesthetic [ 10 ], antipsychotic [ 11 , 12 , 13 ], cardiac [ 14 ] and antihistaminic drugs [ 15 ]. Additionally, the study of drugs with monolayers of liquids is interesting, since recently, lipid miscellas encapsulating different drugs have been proposed as drug delivery systems.…”

“…The authors observed a fluidizing effect, dependent on the time and the drug concentration, which can be produced either from the organic or from the aqueous phase due to the amphiphilic nature of this drug, leading to an increment in the permeability of the film. Nevertheless, the expansion of the lipid layer is enhanced when TFPZ acts from the aqueous phase [ 12 ].…”

Evanescent-wave cavity ring-down spectroscopy applied to electrochemical ion transfer at liquid–liquid interfaces

“…Further addition of the colorant at the aqueous phase at open potential circuit, produces a decrease on the decay time to τ≈20 ±2 ns. Electrochemical studies [12] indicate strong potential dependence of adsorption processes of the complex. However, the decrease on τ is too large and goes beyond the time scale to detect and measure accurately.…”

Electrochemistry of catalase at a liquid|liquid micro-interface array

“…It has immense applications in broad areas like the detection of biomolecules and ionised species, drug release and delivery, solvent extraction, electrochemical biosensor development, and biological membrane simulation [24,25]. There is on-going interest in the electrochemical behaviour of drugs [26], amino acids [27], and a variety of biomacromolecules (e.g. haemoglobin [28], myoglobin [29], lysozyme [30], insulin [31], cytochrome c [32], acid phosphatase [33], oligopeptides [34]) at the ITIES.…”