Interaction of VEGF to gastric low grade MALT lymphoma by Helicobacter heilmannii infection in C57/BL/6 mice

Abstract

Hh was shown to be related to the formation of MALT lymphoma and VEGF is suggested to play a role in this lymphoma.

Is narrow‐band imaging useful for histological evaluation of gastric mucosa‐associated lymphoid tissue lymphoma after treatment?

“…It has already been reported that lymphoma cells migrate into the lamina propria mucosae and ischemia leads to vascular endothelial growth factor (VEGF) activity. Neovascularization induced by VEGF might be related to the TLA feature . Therefore, a target biopsy may contribute to an inaccurate diagnosis.…”

“…Neovascularization induced by VEGF might be related to the TLA feature. 5,18,19 Therefore, a target biopsy may contribute to an inaccurate diagnosis. Nakamura et al 20 reported the predictive value of endoscopic ultrasonography for regression of gastric MALT lymphomas.…”

A case of gastric mucosa-associated lymphoid tissue lymphoma in which magnified endoscopy with narrow band imaging was useful in the diagnosis

“…This finding could be helpful as superficial depressed-type le- sions potentially include circumscribed atrophic gastritis and poorly-differentiated adenocarcinoma. Nakamura et al [15][16] studied mouse gastric MALT lymphoma and reported that VEGF activity in the gastric MALT lymphoma area can potentially induce angiogenesis, and therefore, a rich vascular system is observed in this area compared with normal areas. Further study is necessary to determine whether VEGF also contributes to the generation of abnormal blood vessels observed in human gastric MALT lymphoma.…”

Alteration of angiogenesis in Helicobacter heilmannii‐induced mucosa‐associated lymphoid tissue lymphoma: Interaction with c‐Met and hepatocyte growth factor

“…We have established a mouse model of the gastric MALT lymphoma by per oral infection of H. heilmannii from the cynomolgus monkey . By immunohistochemical analysis of the hypoxia using hypoxyprobe‐1 and HIF1‐α antibody, this tumor clearly shows a hypoxic area and HIF1‐α immunoreactivity with similar localization (Figs ); we, therefore, considered that this model is suitable for the investigation of the altered microcirculation in malignant tumors.…”