Interaction of XRCC1 and XPD Gene Polymorphisms with Lifestyle and Environmental Factors Regarding Susceptibility to Lung Cancer in a High Incidence Population in North East India

Saikia, Basanta; Phukan, Rup Kumar; Sharma, Sandeep; Sekhon, Gaganpreet Singh; Mahanta, Jagadish

doi:10.7314/apjcp.2014.15.5.1993

Cited by 17 publications

(9 citation statements)

References 28 publications

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“…Thus, identification of smokers with high risks of developing lung cancer has substantial preventive implications, involving intensive screening and smoking cessation interventions or campaigns. Recent investigations show genetic association of several polymorphisms with lung cancer in a candidate gene based approach [Sobti et al, ; Parl, ; Sreeja et al, , Shah et al, ; Singh et al, ; Shukla et al, ; Singh and Behera, ; Phukan et al, ; Saikia et al, ; Shen et al, ; Sharma et al, ; Peddireddy et al, ]. A genome‐wide association study also revealed risk of lung cancer in never smokers, particularly women of East Asian origin and reported associations of several susceptibility loci, i.e., 10q25.2 (rs7086803, P = 3.54 × 10 ‐18 ), 6q22.2 (rs9387478, P = 4.14 × 10 ‐10 ) and 6p21.32 (rs2395185, P = 9.51 × 10 ‐9 ) [Lan et al, ] and with the malady.…”

Section: Discussionmentioning

confidence: 99%

“…Several genome-wide association studies (GWAS) have so far identified 16 susceptibility loci (P 5.00 3 10 -8 ) worldwide that are associated with lung cancer risk [Wang et al, 2008;Hu et al, 2011;Dong et al, 2012] and four loci out of them showed evidences of association of lung cancer risk in smokers [Dong et al, 2012]. However, most of these reports were based on Caucasian and Chinese populations, and many identified risk alleles have not been adequately evaluated in Indian population in spite of several case-control investigations on the Indian population from different geographical zones [Sobti et al, 2003[Sobti et al, , 2004[Sobti et al, , 2008[Sobti et al, , 2009Sreeja et al, 2005Sreeja et al, , 2008aSreeja et al, , 2008bSreeja et al, , 2008cJain et al, 2005;Pachouri et al, 2006Pachouri et al, , 2007Kotnis et al, 2008;Shah et al, 2008;Singh et al, 2010Singh et al, , 2016Tilak et al, 2011Tilak et al, , 2013Ihsan et al, 2011a,;Kant Shukla et al, 2013;Natukula et al, 2013;Shukla et al, 2013;Bag et al, 2014;Phukan et al, 2014;Saikia et al, 2014;Uppal et al, 2014;Sharma et al, 2015;Kumari et al, 2016;Peddireddy et al, 2016]. To date, researchers have not been able to delineate the overall effect of the genes and the genetic variations on lung cancer susceptibility in the populations of Indian origin, due to certain conflicting results.…”

Section: Introductionmentioning

confidence: 99%

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Association of 12 polymorphic variants conferring genetic risk to lung cancer in Indian population: An extensive meta‐analysis

Sengupta

Guha

Bhattacharjee

et al. 2017

Environ and Mol Mutagen

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Candidate gene as well as genome-wide association studies identified several polymorphic variants to be associated with lung cancer worldwide including in India. However, contradictory results have failed to estimate the overall effect of the polymorphic variants on the disease. Textmining was conducted on PubMed following specific search strings to gather all the publications related to genetic association with lung cancer in India. Out of 211 PubMed hits only 30 studies were selected for meta-analysis following specific inclusion criteria. Heterogeneity between studies was calculated by Cochran's Q-test (P < 0.05) and heterogeneity index (I ). Publication bias was visualized by funnel plots and Egger's regression test. For each variant, following a fixed-effect model, summary odds ratio (OR) along with 95% confidence interval (CI) was estimated. The meta-analysis revealed three polymorphic variants viz. 'deletion polymorphism (del1) (OR = 1.39, 95% CI = 1.03-1.87, P = 0.027) in GSTT1', 'deletion polymorphism (del2) (OR = 1.30, 95% CI = 1.01-1.67, P = 0.038) in GSTM1' and 'rs1048943 (OR = 1.98, 95% CI = 1.27-3.10, P = 0.002) in CYP1A1' to be associated with lung cancer. However, after multiple testing correction, only rs1048943 was found to be significantly associated (P value = 0.0321) with lung cancer. None of the polymorphic variants showed any evidence of heterogeneity between studies or of publication bias. Our meta-analysis revealed strong association of rs1048943 in CYP1A1, but a suggestive association of deletion polymorphisms in GSTT1 and GSTM1 with lung cancer, which provides a comprehensive insight on the overall effect of the polymorphic variants, reported in various case-control studies on Indian population, on the risk of lung cancer development. Environ. Mol. Mutagen. 58:688-700, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of 12 polymorphic variants conferring genetic risk to lung cancer in Indian population: An extensive meta‐analysis

Sengupta

Guha

Bhattacharjee

et al. 2017

Environ and Mol Mutagen

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“…Our previous reports showed that household exposure to cooking oil fume was associated with the risk of non-smoking female lung cancer [14–18]. A study in a high incidence population in North East India found that the interaction of XRCC1Gln/Gln genotype with exposure of exposure of cooking oil fumes was significantly associated with increased risk for lung cancer [19]. There are some reviews on the risk factors of lung cancer concluded the significant association between cooking oil fume exposure and lung cancer risk [20–21].…”

Section: Introductionmentioning

confidence: 99%

Interaction between Polymorphisms in Pre-MiRNA Genes and Cooking Oil Fume Exposure on the Risk of Lung Cancer in Chinese Non-Smoking Female Population

et al. 2015

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BackgroundBoth genetic polymorphisms and environmental risk factors play important roles in the development of human chronic diseases including lung cancer. This is the first case-control study of interaction between polymorphisms in pre-miRNA genes and cooking oil fume exposure on the risk of lung cancer.MethodsA hospital-based case-control study of 258 cases and 310 controls was conducted. Six polymorphisms in miRNAs were determined by Taqman allelic discrimination method. The gene-environment interactions were assessed on both additive and multiplicative scale. The statistical analyses were performed mostly with SPSS.ResultsThe combination of the risk genotypes of five miRNA SNPs (miR-146a rs2910164, miR-196a2 rs11614913, miR-608 rs4919510, miR-27a rs895819 and miR-423 rs6505162) with risk factor (cooking oil fume exposure) contributed to a significantly higher risk of lung cancer, and the corresponding ORs (95% confidence intervals) were 1.91(1.04-3.52), 1.94 (1.16-3.25), 2.06 (1.22-3.49), 1.76 (1.03-2.98) and 2.13 (1.29-3.51). The individuals with both risk genotypes of miRNA SNPs and exposure to risk factor (cooking oil fumes) were in a higher risk of lung cancer than persons with only one of the two risk factors (ORs were 1.91, 1.05 and 1.41 for miR-146a rs2910164, ORs were 1.94, 1.23 and 1.34 for miR-196a2 rs11614913, ORs were 2.06, 1.41 and 1.68 for miR-608 rs4919510, ORs were 1.76, 0.82 and 1.07 for miR-27a rs895819, and ORs were 2.13, 1.15 and 1.02 for miR-423 rs6505162, respectively). All the measures of biological interaction indicate that there were not indeed biological interactions between the six SNPs of miRNAs and exposure to cooking oil fumes on an additive scale. Logistic models suggested that the gene-environment interactions were not statistically significant on a multiplicative scale.ConclusionsThe interactions between miRNA SNPs and cooking oil fume exposure suggested by ORs of different combination were not statistically significant.

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“…When studying the interaction of XRCC1 and XPD Gene Polymorphisms with Lifestyle and Environmental Factors Regarding Susceptibility to Lung Cancer, Saikia et al [39] found Interaction of XRCC1Gln/Gln genotype with exposure of cooking oil fumes (OR=3.45, CI=1.39-8.58; p=0.008) were significantly associated with increased risk of lung cancer. In addition, Gln/Gln alleles of both XRCC1 and XPD genes showed to amplify the effects of household exposure, smoking and betel quid chewing on lung cancer risk.…”

Section: A Cooking Fumes Effects On the Genementioning

confidence: 99%

Cooking Fumes and Relative Diseases

Wang¹,

Liu²,

He³

2017

Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)

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Abstract-Cooking fumes are mixture of various toxic components such as aldehydes, heterocyclic amines (HCAs), polycyclic aromatic hydrocarbons (PAHs), fat aerosols and particulate matters (PM), which are mainly produced during or after cooking. Due to the toxic contents of CFs, CFs might cause lung toxicity, immune toxicity, hereditary toxicity, potential carcinogenicity and so on to organism. There were several studies investigated the toxicity impact of CFs. However, comprehensive review about the production, composition harm to the contacts and reduction methods of CFs is still lacking. In this review, the production, composition and effects on the contacts of cooking fumes were presented. In addition, reduction methods of cooking fumes were also presented. This review would provide references for the avoidance of CFs relative disease and the comprehensive disposal of CFs.

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Interaction of XRCC1 and XPD Gene Polymorphisms with Lifestyle and Environmental Factors Regarding Susceptibility to Lung Cancer in a High Incidence Population in North East India

Cited by 17 publications

References 28 publications

Association of 12 polymorphic variants conferring genetic risk to lung cancer in Indian population: An extensive meta‐analysis

Association of 12 polymorphic variants conferring genetic risk to lung cancer in Indian population: An extensive meta‐analysis

Interaction between Polymorphisms in Pre-MiRNA Genes and Cooking Oil Fume Exposure on the Risk of Lung Cancer in Chinese Non-Smoking Female Population

Cooking Fumes and Relative Diseases

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