Interaction of α-lactalbumin with lipids and possible implications for its emulsifying properties – A review

Study on the interactions of trans-resveratrol and curcumin with bovine α-lactalbumin by spectroscopic analysis and molecular docking

“…So far, several studies showed the strong interaction between BLA and metal ions such as Ca 2+ ,Na + , Cd 2+ , Zn 2+ , Co 2+ and Mg 2+ (Mizuguchia et al .,1997;Hendrix et al, 2000;Noyelle and Dael., 2002;Rasmussen and Bjerrum., 2003;Farkas et al, 2005;Dzwolak et al, 2009), fatty acids (Yang et al, 2006;Barbanaa et al,2006;Pettersson-Kastberg., 2009;Kehoe and Brodkorb., 2014), cosolvents (Guna Sekhar andPrakash., 2008), surfactants (Housaindokht et al, 2005;Chamani., 2010) and lipids (Barbana and Perez., 2011;Chaudhuri and Chattopadhyay., 2014). A C C E P T E D M A N U S C R I P T Graphical abstract…”

Voltammetry of proteins at liquid–liquid interfaces

“…Furthermore, the behaviour of proteins at the ITIES can also be important in understanding and controlling protein stability in biopharmaceutical formulations 32 and in foodstuffs. 33 Consequently, the fundamental chemistry involved in a protein reaction at an ITIES offers scope for impact outside the research laboratory.…”

Direct observation of alpha-lactalbumin, adsorption and incorporation into lipid membrane and formation of lipid/protein hybrid structures

“…Bovine α-La is a small (14.2 kDa) acidic (pI 4.8) Ca 2+ binding milk protein, composed of 123 aminoacids [36]. It has been widely used as a model for protein molten globule state in folding studies [37][38][39][40] and largely studied for its capacity to interact with lipids [11,41]. The interaction of α-La with lipids plays an essential role in many biological processes such as the biosynthesis of lactose and the secretion of the protein in the milk [41].…”