Interaction profile of Zizyphus jujuba with phenytoin, phenobarbitone, and carbamazepine in maximal electroshock‐induced seizures in rats

Pahuja, Monika; Kleekal, Thomas; Reeta, K.H.; Tripathi, Manjari; Gupta, Yogendra Kumar

doi:10.1016/j.yebeh.2012.08.014

Cited by 30 publications

(16 citation statements)

References 24 publications

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“…Kindling and MES (Maximal electroshock) are common models used in anticonvulsant studies of new drugs in animals, and for kindling some chemicals as pentylentetra- zole (PTZ), bicoculine or picrotoxine were used (6)(7)(8). Recently, herbal medicine has been used for many pathological conditions such as diabetes, depression, seizures and other diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, herbal medicine has been used for many pathological conditions such as diabetes, depression, seizures and other diseases. It was found that several plants possess neurobehavioral activities, and therefore, they have been used as alternatives in modern medicine (7). In this study, we aimed to assess the anticonvulsant effects of methanolic extracts of flowering shoots of E. caucasicum.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Anticonvulsant Activities of Eryngium caucasicum with Maximal Electroshock and Kindling Model of Seizure in Mice

Ebrahimzadeh

Chitsaz

Shokrzadeh

et al. 2016

Iran J Psychiatry Behav Sci

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of Anticonvulsant Activities of Eryngium caucasicum with Maximal Electroshock and Kindling Model of Seizure in Mice

Ebrahimzadeh

Chitsaz

Shokrzadeh

et al. 2016

Iran J Psychiatry Behav Sci

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“…For MES, the protocol by [23] was slightly varied to suit the limitations of our equipment (maximum current output 100 mA). MES was induced using a 70 mA current pulse, 0.2 s duration at 60 Hz [41]. Preliminary experiments also showed that this protocol was consistent in inducing stage 4/5 seizures in the rats.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Anticonvulsant Actions of Dibromophenyl Enaminones Using In Vitro and In Vivo Seizure Models

et al. 2014

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Epilepsy and other seizure disorders are not adequately managed with currently available drugs. We recently synthesized a series of dibromophenyl enaminones and demonstrated that AK6 and E249 were equipotent to previous analogs but more efficacious in suppressing neuronal excitation. Here we examined the actions of these lead compounds on in vitro and in vivo seizure models. In vitro seizures were induced in the hippocampal slice chemically (zero Mg2+ buffer and picrotoxin) and electrically using patterned high frequency stimulation (HFS) of afferents. In vivo seizures were induced in rats using the 6 Hz and the maximal electroshock models. AK6 (10 µM) and E249 (10 µM) depressed the amplitude of population spikes recorded in area CA1 of the hippocampus by −50.5±4.3% and −40.1±3.1% respectively, with partial recovery after washout. In the zero Mg2+ model, AK6 (10 µM) depressed multiple population spiking (mPS) by −59.3±6.9% and spontaneous bursts (SBs) by −65.9±7.2% and in the picrotoxin-model by −43.3±7.2% and −50.0±8.3%, respectively. Likewise, E249 (10 µM) depressed the zero-Mg2+-induced mPS by −48.8±9.5% and SBs by −55.8±15.5%, and in the picrotoxin model by −37.1±5.5% and −56.5±11.4%, respectively. They both suppressed post-HFS induced afterdischarges and SBs. AK6 and E249 dose-dependently protected rats in maximal electroshock and 6 Hz models of in vivo seizures after 30 min pretreatment. Their level of protection in both models was similar to that obtained with phenytoin Finally, while AK6 had no effect on locomotion in rats, phenytoin significantly decreased locomotion. AK6 and E249, suppressed in vitro and in vivo seizures to a similar extent. Their in vivo activities are comparable with but not superior to phenytoin. The most efficacious, AK6 produced no locomotor suppression while phenytoin did. Thus, AK6 and E249 may be excellent candidates for further investigation as potential agents for the treatment of epilepsy syndromes with possibly less CNS side effects.

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“…Another author demonstrated the anticonvulsant effect of the hydroalcoholic extract of Z. jujuba, as well as the amelioration of cognitive impairment induced by seizures in rats [98]. Furthermore, the hydroalcoholic extract of Z. jujuba potentiated the anticonvulsant effect of phenytoin and phenobarbital without altering the serum levels of these drugs [99].…”

Section: Jujube (Hongzao)mentioning

confidence: 97%

Review of the use of botanicals for epilepsy in complementary medical systems — Traditional Chinese Medicine

Xiao¹,

Yan²,

Chen

et al. 2015

Epilepsy & Behavior

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Interaction profile of Zizyphus jujuba with phenytoin, phenobarbitone, and carbamazepine in maximal electroshock‐induced seizures in rats

Cited by 30 publications

References 24 publications

Evaluation of Anticonvulsant Activities of Eryngium caucasicum with Maximal Electroshock and Kindling Model of Seizure in Mice

Evaluation of Anticonvulsant Activities of Eryngium caucasicum with Maximal Electroshock and Kindling Model of Seizure in Mice

Evaluation of Anticonvulsant Actions of Dibromophenyl Enaminones Using In Vitro and In Vivo Seizure Models

Review of the use of botanicals for epilepsy in complementary medical systems — Traditional Chinese Medicine

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