Interactions among Interleukin-6, C-Reactive Protein and Interleukin-6 (-174) G/C Polymorphism in the Pathogenesis of Crohn’s Disease and Ulcerative Colitis

Takač, Boris; Mihaljević, Silvio; Glavaš‐Obrovac, Ljubica; Kibel, Aleksandar; Suver-Stević, Mirjana; Canecki-Varžić, Silvija; Samardžija, Marko; Rajkovac, Ines; Kovač, Damir; Štefanić, Mario

doi:10.20471/acc.2020.59.01.09

Cited by 7 publications

(6 citation statements)

References 94 publications

(122 reference statements)

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“…Boris Takač and colleagues also observed significant differences in IL-6 levels between patients with IBD and healthy subjects. 60 Poullis et al [61][62][63] found higher CRP concentrations in patients with CD. We observed high levels of all inflammatory markers in all patients, especially in those with active disease, which is consistent with the aforementioned findings.…”

Section: Discussionmentioning

confidence: 95%

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Vitamin D levels in the assessment of Crohn's disease activity and their relation to nutritional status and inflammation

Zheng

et al. 2023

J Human Nutrition Diet

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Background Crohn's disease (CD) is frequently associated with malnutrition, inflammation and a deficiency of vitamin D (VD) with the relationships between these symptoms being poorly defined. VD is a modulator of the immune system and is associated with the onset of CD and disease activity. The level of serum VD may have potential in the assessment of CD activity. This study aimed to evaluate the relationships between VD, nutritional status and inflammation, and to identify more accurate VD thresholds. Methods The study included 76 outpatients with CD diagnosed between October 2018 and October 2020 and 76 healthy volunteers. Levels of serum 25(OH)D and nutritional indicators, as well as biochemical and disease activity assessments, were conducted. Results Patients with CD and healthy participants were found to differ significantly in their 25(OH)D levels as well in levels of nutritional and inflammatory indicators. The optimal VD cut‐off value was found to be 46.81 nmol/L for CD development and 35.32 nmol/L for disease activity. Levels of 25(OH)D were correlated with both nutritional status and inflammation. Conclusions The VD level is likely to be a useful additional tool in the evaluation of CD patients and predicting the disease activity and clinical response. The VD level may relate both to the nutritional status and levels of inflammation in CD patients, and disease progression.

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Section: Discussionmentioning

confidence: 95%

“…Boris Takač and colleagues also observed significant differences in IL‐6 levels between patients with IBD and healthy subjects 60 . Poullis et al 61–63 found higher CRP concentrations in patients with CD.…”

Section: Discussionmentioning

confidence: 95%

Vitamin D levels in the assessment of Crohn's disease activity and their relation to nutritional status and inflammation

Zheng

et al. 2023

J Human Nutrition Diet

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“…Previous studies have clearly suggested that common genetic components may underlie different immune-related diseases ( 38 , 39 ). The etiopathogenesis of IgAV is complex and not fully understood, and may involve a number of interactions between various environmental and genetic factors ( 10 , 11 , 40 ).…”

Section: Discussionmentioning

confidence: 99%

Association between High Mobility Group Box 1 Protein Gene (Rs41369348) Polymorphism and Immunoglobulin A Vasculitis in Children

Batnožić Varga

2023

ACC

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SUMMARY Immunoglobulin A vasculitis (IgAV) or Henoch-Schönlein purpura is the most prevalent systemic small vessel vasculitis in childhood. High mobility group box 1 protein (HMBG1) is a pleiotropic cytokine that functions as a pro-inflammatory signal, important for the activation of antigen-presenting cells and propagation of inflammation. HMGB1 is implicated in the pathophysiology of a variety of inflammatory diseases. The aim of this study was to investigate the role of single nucleotide polymorphism rs41369348 for HMGB1 gene in the susceptibility and clinical features of patients meeting the classification criteria for IgAV. DNA was extracted from blood cells of 76 children with IgAV and 150 age-matched healthy controls. Clinical data and laboratory parameters were collected for all IgAV patients. Although there was a higher frequency of heterozygous A/delA genotype of this gene polymorphism in IgAV group as compared with control group, no genotype difference was observed between these two groups. No statistically significant genotype differences were disclosed when patients with different IgAV clinical features were compared. In conclusion, in this study, polymorphism rs41369348 for HMGB1 was not associated with increased susceptibility to childhood IgAV, its severity or different clinical manifestations.

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“…IL-6 is a common pro-inflammatory cytokine. It has been shown that serum levels of this pro-inflammatory cytokine were significantly increased in IBD patients [18]. Further research found a correlation between IL-6 expression and disease activity in patients with Crohn's disease (CD) and UC [19].…”

Section: Discussionmentioning

confidence: 99%

The “whole ingredients extract” of Astragali Radix improves the symptoms of dextran sulfate sodium-induced ulcerative colitis in mice through systemic immunomodulation

Linghu

Xiong

et al. 2022

Chin Med

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Background: Ulcerative colitis (UC) is a common inflammatory intestinal disease. Astragali Radix (AR) is one of the traditional Chinese medicines used in clinic for UC treatment. In our previous study, the whole ingredient extract (WIE) from AR have been proved to possess better immunomodulatory effects on immunosuppressed mice compared with the conventional water extraction (WAE). In the present study, we further evaluated the therapeutic effects of WIE against dextran sodium sulfate (DSS)-induced UC in mice through systemic immune regulation. Methods:Gradient solvent extraction has been used to prepare the WIE of AR. The HPLC-MS analysis approach has been employed to analyze and compare the chemical differences between WAE and WIE. UC model was reproduced in 3% DSS-induced C57BL/6 mice for 6 days. Flow cytometric analysis for splenic lymphocyte subset. ELISA kits were used to determine the cytokines in the serum and colon tissues. The histopathological characteristics of colon were evaluated by hematoxylin-eosin staining and immunohistochemistry. Results:The chemical compositions and the contents of main active ingredients were more abundant and higher in WIE than those in WAE. The WIE treatment altered a better action on reducing colitis disease activity index (DAI) and histological scores, as well as the recovered body weight and increased colon length in mice compared to the WAE group. Additionally, WIE showed better effects in recovering the levels of peripheral white blood cells in blood and cytokines (IL-2, IL-6 and MCP-1) in serum or colon tissues, improving the percentage of CD3 + and the ratio of CD4 + / CD8 + in the spleen, and inhibiting the spleen enlargement in DSS-induced UC mice. Conclusions: WIE has a more complete chemical composition than WAE. Meanwhile, WIE possesses better therapeutic effects on UC through resuming dysfunctional immunity in mice.

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Interactions among Interleukin-6, C-Reactive Protein and Interleukin-6 (-174) G/C Polymorphism in the Pathogenesis of Crohn’s Disease and Ulcerative Colitis

Cited by 7 publications

References 94 publications

Vitamin D levels in the assessment of Crohn's disease activity and their relation to nutritional status and inflammation

Vitamin D levels in the assessment of Crohn's disease activity and their relation to nutritional status and inflammation

Association between High Mobility Group Box 1 Protein Gene (Rs41369348) Polymorphism and Immunoglobulin A Vasculitis in Children

The “whole ingredients extract” of Astragali Radix improves the symptoms of dextran sulfate sodium-induced ulcerative colitis in mice through systemic immunomodulation

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