Interactions between age and apoE genotype on fasting and postprandial triglycerides levels

Carvalho-Wells, A. L.; Jackson, Kim G.; Gill, Rosalynn; Olano-Martín, Estíbaliz; Lovegrove, Julie A.; Williams, Christine M.; Minihane, Anne Marie

doi:10.1016/j.atherosclerosis.2010.06.036

Cited by 36 publications

(33 citation statements)

References 39 publications

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“…These results are in line with those of most recent studies [40] [41]. However, on the contrary to the present study, some previous studies have suggested that apoE genotype also affects other cardiovascular risk factors [42]- [45]. High blood pressure has been associated with the presence of apoE 4 allele [44], but also with the apoE 2 allele [13] [43] [46] and Helkala et al (2001) found that carriers of apoE 2 allele had higher fasting glucose and 2 h blood glucose than apoE 3 and 4 carriers [43].…”

Section: Discussioncontrasting

confidence: 55%

Using Individual, ApoE Genotype-Based Dietary and Physical Activity Advice to Promote Healthy Lifestyles in Finland—Impacts on Cardiovascular Risk Markers

Hietaranta-Luoma¹,

Åkerman²,

Tahvonen³

et al. 2015

OJPM

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Aim: There is increasing demand for individualized health advice. The aim of this study was to assess the effects on cardiovascular risk markers of receiving personal genetic health information, using apoE genotypes as a tool for promoting lifestyle changes. ApoE was chosen because it had a significant impact on lipid metabolism and cholesterol absorption, all factors for CVD. Methods: This study was a one-year explanatory intervention study for healthy adults, aged between 20 -67 years old (n = 106). Their clinical markers (serum lipids, blood glucose, blood pressure, Body Mass Index, body fat percentage and waist circumference) were measured three times during the intervention. The clinical effects were assessed for three groups: a high risk group (Ɛ4+, n = 16); a low-risk group (Ɛ4−, n = 35); and a control group (n = 55). Results: The triglyceride values and waist circumference lowered more in Ɛ4+ compared with the control group (p < 0.05; alpha value 0.005) during the intervention. Conclusion: The personal genetic information, based on apoE, may have positive effects on cardiovascular risk markers (e.g., improvement in triglyceride values). The individual health information, based on genotyping could be a potential option in the prevention of CVD. More research is required on how to utilize genotype-based health information in the prevention of lifestyle-related diseases.

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Section: Discussioncontrasting

confidence: 55%

Using Individual, ApoE Genotype-Based Dietary and Physical Activity Advice to Promote Healthy Lifestyles in Finland—Impacts on Cardiovascular Risk Markers

Hietaranta-Luoma¹,

Åkerman²,

Tahvonen³

et al. 2015

OJPM

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“…In the population at large, the e2 and the e4 alleles have been linked to high triglyceride levels [19][20][21]31]. The LDL receptor recognises ApoE and ApoB-100 and plays a crucial role in cholesterol homeostasis [32], whereas the structurally related very LDL receptor recognises ApoE, but not ApoB-100, and plays an important role in triglyceride metabolism [33].…”

Section: Discussionmentioning

confidence: 99%

“…There are three common alleles of the APOE gene (e2, e3 and e4). Individuals carrying the e4 allele have higher total and LDL cholesterol levels than individuals with the commonest e3e3 genotype and those carrying the e2 allele have lower levels of total and LDL cholesterol [19][20][21]. In addition, associations between APOE genotype and triglycerides [18] and circulating apolipoprotein (Apo)E and ApoB concentrations have been reported in the general population [18,22,23].…”

Section: Introductionmentioning

confidence: 95%

“…In addition, associations between APOE genotype and triglycerides [18] and circulating apolipoprotein (Apo)E and ApoB concentrations have been reported in the general population [18,22,23]. Taken together, e4 allele carriers represent the risky APOE genotype [19][20][21][22][23]. Nevertheless, the role of APOE gene polymorphisms in lipid metabolism disturbances in OSA, a condition known to be associated with increased cardiovascular risk, is unclear.…”

Section: Introductionmentioning

confidence: 99%

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Effects of apolipoprotein E genotype on serum lipids in obstructive sleep apnoea

et al. 2013

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There is increasing evidence that intermittent hypoxia resulting from obstructive sleep apnoea (OSA) is independently associated with dyslipidaemia. Currently, no data exist on potential links between OSA-related dyslipidaemia and susceptibility genes for dyslipidaemia in such patients. Our aim was to study the effects of the apolipoprotein E (APOE) genotype and sleep apnoea severity on atherogenic dyslipidaemia in patients with OSA.519 clinically stable subjects prospectively recruited at a tertiary referral teaching hospital underwent full polysomnography. APOE gene polymorphisms were assessed using real-time PCR.In all APOE genotype groups, serum triglycerides increased while high-density lipoprotein (HDL) cholesterol was reduced with increasing severity of OSA in each APOE genotype group, whereas the deleterious effects of OSA on serum apolipoprotein (Apo)B levels were observed in e2 carriers and the e3/e3 genotype only. Nevertheless, the e4 allele carriers had ApoB levels within the risk range, irrespective of nocturnal hypoxia. In addition, among patients with the high-risk e4 genotype, those with the most severe nocturnal hypoxia had significantly higher triglyceride and lower HDL cholesterol levels compared with nonhypoxic e4 subjects. APOE genotype and the oxygen desaturation index were both independent predictors of serum triglyceride levels (p50.009 and p,0.001, respectively; R 2 50.148) and ApoB levels (p50.001 and p50.003, respectively; R 2 50.104). Our findings suggest that OSA has adverse effects on several lipid parameters over and above the effects carried by APOE genotype. Further st1udies are needed to analyse the effects of high-risk genotypes on metabolic and cardiovascular outcomes in patients with OSA. @ERSpublications OSA has adverse effects on several lipid parameters in addition to the effects carried by the APOE genotype

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“…Other studies have shown that APOE genotype may also affect the impact of LC n-3 PUFA on inflammation, triglycerides concentration or cholesterol level (Anil, 2007;Carvalho-Wells et al, 2010;Carvalho-Wells et al, 2012). Further research is needed to better understand the underlying mechanisms of this gene X diet interaction.…”

Section: Resultsmentioning

confidence: 99%

Long-chain omega3 polyunsaturated fatty acids and cognition in older people: interaction with APOE genotype

Barberger‐Gateau

Samieri

Cunnane³

2015

OCL

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-Basic research and epidemiological studies suggest a protective effect of long-chain omega3 polyunsaturated fatty acids (LC n-3 PUFA) against age-related cognitive decline. However, most randomized controlled trials with LC n-3 PUFA supplements have yielded disappointing results on cognitive outcomes in older persons. One explanation for this discrepancy may be an inadequate targeting of potential beneficiaries of LC n-3 PUFA according to their Apolipoprotein E (APOE) genotype. The aim of this paper was to examine the potential modifying effect of APOE genotype on LC n-3 PUFA metabolism and its relation to cognitive decline in older persons. At least five epidemiological studies and three intervention studies with LC n-3 PUFA supplements have found an interaction between LC n-3 PUFA and APOE genotype on cognition. However, the direction of the effect is inconsistent across studies: the impact of LC n-3 PUFA on cognition is stronger in APOE4 carriers (the main genetic risk factor for Alzheimer's disease) in some studies, but conversely stronger in APOE4 non-carriers in other studies. These discordant results may be explained by different age groups, cognitive status, measures of cognition, or amounts of DHA intake across studies. Experimental studies suggest that the APOE4 genotype modifies the metabolism of DHA. The APOE genotype should be systematically taken into account and interactions tested in epidemiological and intervention studies with LC n-3 PUFA. Further research is needed to better understand the underlying mechanisms of this gene X diet interaction.Keywords: Cognition / aging / omega3 fatty acids / Apolipoprotein E gene / DHA Résumé -Acides gras oméga-3 à longue chaîne et cognition chez les sujets âgés : interaction avec le géno-type APOE. La recherche fondamentale et les études épidémiologiques suggèrent un effet protecteur des acides gras oméga3 à longue chaîne (AGPI-LC n-3) contre le déclin cognitif lié à l'âge. Cependant les études d'intervention avec des suppléments d'AGPI-LC n-3 ont donné des résultats décevants sur la cognition. Une raison pourrait en être un ciblage inadéquat des bénéficiaires potentiels d'une supplémentation en raison notamment de leur génotype pour le gène de l'Apolipoprotéine E (APOE). L'objectif de cet article était d'explorer l'effet potentiellement modificateur du géno-type de l'APOE sur le métabolisme des AGPI-LC n-3 et sa relation avec le déclin cognitif chez le sujet âgé. Au moins cinq études épidémiologiques et trois études d'intervention ont mis en évidence une interaction entre les AGPI-LC n-3 et le génotype de l'APOE sur la cognition des personnes âgées. Cependant la direction de l'effet est inconstant entre les études, certaines montrent un impact des AGPI-LC n-3 uniquement chez les porteurs de l'allèle epsilon4 (APOE4), principal facteur de risque génétique de maladie d'Alzheimer, et d'autres inversement un effet chez les non-porteurs de l'APOE4. Ces résultats discordants peuvent s'expliquer par des différences d'âge, de statut cognitif, de domaine d...

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Interactions between age and apoE genotype on fasting and postprandial triglycerides levels

Cited by 36 publications

References 39 publications

Using Individual, ApoE Genotype-Based Dietary and Physical Activity Advice to Promote Healthy Lifestyles in Finland—Impacts on Cardiovascular Risk Markers

Using Individual, ApoE Genotype-Based Dietary and Physical Activity Advice to Promote Healthy Lifestyles in Finland—Impacts on Cardiovascular Risk Markers

Effects of apolipoprotein E genotype on serum lipids in obstructive sleep apnoea

Long-chain omega3 polyunsaturated fatty acids and cognition in older people: interaction with APOE genotype

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