Interactions between cadmium, lead, mercury, and arsenic and depression: A molecular mechanism involved

Nguyen, Hai Duc; Kim, Min-Sun

doi:10.1016/j.jad.2023.02.013

Cited by 14 publications

(7 citation statements)

References 80 publications

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“…In recent years, more studies have reported a link between exposure to cadmium and mental health [ 19 , 21 , 22 ]. To our knowledge, this is the first study evaluating the connection between blood cadmium and depression in U.S. adult women.…”

Section: Discussionmentioning

confidence: 99%

Association between blood cadmium and depression varies by age and smoking status in US adult women: a cross-sectional study from NHANES 2005–2016

Ji,

Wang

2024

Environ Health Prev Med

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Section: Discussionmentioning

confidence: 99%

Association between blood cadmium and depression varies by age and smoking status in US adult women: a cross-sectional study from NHANES 2005–2016

Ji,

Wang

2024

Environ Health Prev Med

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“…These solutions were further diluted for use. The effects of different factors, including dosage (0.1-12 g/L), adsorption time (0-1440 min), pH (3)(4)(5)(6)(7)(8)(9), and initial concentration, were investigated. The composite solutions of Cd(II) and As(V) for the isothermal adsorption experiments were prepared as follows: the concentration of Cd(II) was held constant (1 mg/L), and the initial concentration of As(V) was varied (1-100 mg/L); the concentration of As(V) was kept constant (40 mg/L), and the initial concentration of Cd(II) was varied (1-100 mg/L).…”

Section: Adsorption Experimentsmentioning

confidence: 99%

“…When contaminants in aquatic and soil environments exceed regulatory standards and remain unremediated, they pose significant health risks [2,3], Long-term exposure to Cd and As in humans can result in various diseases. For instance, prolonged exposure to Cd has been associated with lung cancer, osteoporosis, and spinal deformities [4,5], while the excessive intake of As can lead to skin cancer, liver cancer, bronchitis, acute gastroenteritis, kidney damage, and cardiovascular diseases [5,6]. They are released into aquatic and terrestrial environments mainly through anthropogenic activities such as the discharge of wastewater and sewage, the use of pesticides and fertilizers, the mining of ores, and the burning of fuels, and they accumulate in living organisms through the food chain; they present a significant threat to the environment and human well-being [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Lanthanum-Modified Phosphogypsum Red Mud Composite for the Co-Adsorption of Cadmium and Arsenic: Mechanism Study and Soil Remediation

Shang,

Geng,

Sun

et al. 2024

Agriculture

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With the development of industrial activities and the agricultural and mining industries, farmland soils are facing serious problems related to heavy metal contamination, especially cadmium (Cd) and arsenic (As) contamination. In this study, two industrial by-products, phosphogypsum (PG) and red mud (RM), were modified by lanthanum (La) impregnation to form a new composite (L-PR) to investigate the adsorption performance of Cd(II)/As(V) in both single and binary systems. The adsorption mechanisms of Cd(II)/As(V) on L-PR were analyzed using SEM, XRD, FTIR, and XPS. The passivation effect of L-PR on the Cd-As composite contaminated soil was confirmed through a soil cultivation experiment. The adsorption experiments revealed that L-PR showed superior adsorption capabilities for Cd(II) and As(V) compared to PG and RM. Additionally, L-PR was found to be less affected by changes in pH. The kinetic studies indicated that Cd(II) and As(V) adsorption by L-PR followed the second-order kinetic model most accurately. Isothermal adsorption experiments revealed that the adsorption of Cd(II) by L-PR was more in accordance with the Freundlich model, while As(V) was more in accordance with the Langmuir model. The mechanisms of Cd(II) and As(V) adsorption on L-PR involved electrostatic attraction, ion exchange, complexation, and precipitation. The adsorption of Cd(II) is dominated by complexation and precipitation, and the adsorption of As(V) is dominated by ion exchange and complexation. Soil cultivation experiments showed that L-PR significantly reduced the available Cd and As concentrations in soil by 86.01% and 27.80%, respectively, and it could induce the transformation of non-stable Cd(II)/As(V) to the more stable residual. In summary, L-PR exhibits facile preparation, excellent adsorption performance, and is capable of simultaneously removing Cd(II) and As(V) from aqueous solutions while immobilizing these contaminants in soil. These remarkable attributes made it a highly promising alternative for the simultaneous treatment of various toxic metal contaminants.

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“…The researchers conducted an observation and found that the presence of arsenic had an impact on 19 genes that are associated with the development of depression. The genes were identified as being situated on chromosome 1q31.1 (chr1q31.1) [327]. The genetic expression of SOD1, IL6, PTGS2, PON1, BDNF, and ALB was modified by the presence of a mixture of heavy metals.…”

Section: Arsenicmentioning

confidence: 99%

“…This alteration underscores the significance of oxidative stress, pro-inflammatory cytokines, paraoxonase activity, neurotrophic factors, and antioxidants in relation to depression. Moreover, it suggests the potential for therapeutic interventions targeting these specific genes in the treatment of depression [327]. The presence of arsenic leads to a substantial elevation in oxidative stress levels, resulting in detrimental consequences.…”

Section: Arsenicmentioning

confidence: 99%

Trace Elements Levels in Major Depressive Disorder—Evaluation of Potential Threats and Possible Therapeutic Approaches

Baj,

Bargieł,

Cabaj

et al. 2023

IJMS

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The multifactorial etiology of major depressive disorder (MDD) includes biological, environmental, genetic, and psychological aspects. Recently, there has been an increasing interest in metallomic studies in psychiatry, aiming to evaluate the role of chosen trace elements in the MDD etiology as well as the progression of symptoms. This narrative review aims to summarize the available literature on the relationship between the concentration of chosen elements in the serum of patients with MDD and the onset and progression of this psychiatric condition. The authors reviewed PubMed, Web of Science, and Scopus databases searching for elements that had been investigated so far and further evaluated them in this paper. Ultimately, 15 elements were evaluated, namely, zinc, magnesium, selenium, iron, copper, aluminium, cadmium, lead, mercury, arsenic, calcium, manganese, chromium, nickel, and phosphorus. The association between metallomic studies and psychiatry has been developing dynamically recently. According to the results of current research, metallomics might act as a potential screening tool for patients with MDD while at the same time providing an assessment of the severity of symptoms. Either deficiencies or excessive amounts of chosen elements might be associated with the progression of depressive symptoms or even the onset of the disease among people predisposed to MDD.

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Interactions between cadmium, lead, mercury, and arsenic and depression: A molecular mechanism involved

Cited by 14 publications

References 80 publications

Association between blood cadmium and depression varies by age and smoking status in US adult women: a cross-sectional study from NHANES 2005–2016

Association between blood cadmium and depression varies by age and smoking status in US adult women: a cross-sectional study from NHANES 2005–2016

Lanthanum-Modified Phosphogypsum Red Mud Composite for the Co-Adsorption of Cadmium and Arsenic: Mechanism Study and Soil Remediation

Trace Elements Levels in Major Depressive Disorder—Evaluation of Potential Threats and Possible Therapeutic Approaches

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