INTERACTIONS BETWEEN CLONIDINE AND Α-Adrenoceptor ANTAGONISTS

Hersom, A. S.; Metcalf, G.

doi:10.1016/b978-0-08-023768-8.52325-2

Cited by 7 publications

(2 citation statements)

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“…At present, the clonidine-induced sedation is thought to be due to central %-adrenoreceptor stimulation Drew, Gower & Marriott, 1979) but the central mechanism by which clonidine lowers blood pressure is still unclear and has been proposed to result from stimulation of a,-adrenoreceptors (Hersom, Finch & Metcalf, 1978) and a,-adrenoreceptors . Therefore, it remains uncertain whether the sedative and cardiovascular effects of clonidine can be separated.…”

Section: Introduction 7mentioning

confidence: 99%

Presynaptic Α‐adrenoreceptors; In Vitro Methods and Preparations Utilised in the Evaluation of Agonists and Antagonists

Doxey¹,

Roach²

1980

Journal of Autonomic Pharmacology

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Section: Introduction 7mentioning

confidence: 99%

Presynaptic Α‐adrenoreceptors; In Vitro Methods and Preparations Utilised in the Evaluation of Agonists and Antagonists

Doxey¹,

Roach²

1980

Journal of Autonomic Pharmacology

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“…The potency of guanabenz relative to clonidine was similar in both the cardiovascular and behavioural tests used in this study. These results suggest that guanabenz, like clonidine (Hersom, Finch & Metcalf, 1978) may reduce blood pressure and heart rate by an action on central a-adrenoceptors similar in nature to peripheral a2-adrenoceptors. The sedation observed with both guanabenz and clonidine may also be related to agonist activity at central x-adrenoceptors & Whalley, 1980).…”

Section: Pmentioning

confidence: 78%

PROCEEDINGS OF THE British Pharmacological Society 10th‐12th September, 1980

1981

British J Pharmacology

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* Imipramine was added to the homogenate otherwise the animals were identical to the control group. ** Uptake is expressed per 10 mg cortical protein. References COPPEN, A., RAMA RAO, V.A.. SWADE, C. & WOOD, K. (1979). Inhibition of 5-hydroxytryptamine reuptake by amitriptyline and zimelidine and its relationship to their therapeutic action. Psychopharmacology, 63, 125-129. DICKISON, S.E., DIGGORY, G.L., WOOD, M.D. & WYLLIE, M.G. (1980). The effects of a selective uptake blocker on 5-HT turnover in the CNS. Br. J. Pharmac., proceedings in press. GRAY, E.G. & WHITTAKER, V.P. (1962). The isolation of nerve endings from brain: an electron microscopic study of cell fragments derived by homogenization and centrifugation.

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