Interactions Between Dental Composite Resins and Saliva A comparative biochemical in vitro study

Abstract

This in vitro study analyses the biochemical interaction between saliva and three types of dental composite resins (a direct resin, an indirect resin and a dual-cure resin used for cementation of indirect dental restorations). The resin samples were obtained following a specific protocol and in line with the producers� recommendations; the resin samples were incubated with saliva samples collected from 19 healthy volunteers. The obtained results showed that the tested composite resins did not produce significant changes in oxidative stress parameters that were analysed (albumin, uric acid, GGT / gamma glutamyl transferase, OXSR-1 / oxidative stress responsive kinase 1) and do not influence the inflammatory salivary status reflected by the levels of IL-6 - an inflammatory marker.

Molecular Interactions between Saliva and Dental Composites Resins: A Way Forward

“…The obtained results of this study (that pointed out that the tested resins do not interfere with salivary oxidative stress), together with other reported data concerning composite resins’ biocompatibility, have clinical applicability, and highlight, increasingly, the special biological properties of these modern dental materials [ 2 ].…”

“…The in vitro study of Pantea et al revealed that the tested composite resins did not induce significant changes of the salivary redox status markers (uric acid, gamma glutamyl transferase, and oxidative stress responsive kinase-1) [ 2 ]. The tested dental composite resins were: a resin for direct dental restorations—GC G-ænial Posterior/GC Corporation/Tokyo/Japan—that have an organic matrix (UDMA/Urethane dimethacrylate/dimethacrylate co-monomer), filler, pigments and photo-initiators; a resin for indirect dental restorations—Gradia Lab Indirect Restoration System/GCCorporation/Tokyo/Japan—a nano-hybrid composite, having ultra-fine fillers with very high density and homogeneous distribution, mixed in the resin matrix; a composite resin for cementation of indirect dental restorations—G-Cem Link Force//GCCorporation/Tokyo/Japan—an universal dual cure resin cement.…”

“…The primary interest of material scientists and dental medicine researchers is the development of new dental materials characterized by reduced polymerization shrinkage, better healing, and mechanical and aesthetic properties [ 1 ]. Composite resins represent dental materials providing a very good biocompatibility within the oral environment [ 1 , 2 ]. Biocompatibility represents the ability of a biomaterial to sustain a specific function in the context of a medical treatment without generating any harmful local or systemic effects, but inducing the most advantageous cellular or tissue responses, in a given situation, optimizing and completing in this way the medical therapy [ 3 ].…”

“…The improvement of composite resins formula with compounds that could provide antiseptic properties [ 2 ] represents an important topic in the medical scientific research. Currently, nanotechnology and nanoscience also play an important role in development of new dental composite resins [ 6 ].…”

Biochemical Interaction between Materials Used for Interim Prosthetic Restorations and Saliva

“…Certain aspects concerning the conventional and modern materials used for manufacturing interim prosthetic restorations represent important topics in present-day scientific research: the dimensional accuracy and mechanical behavior (compression strength, flexural strength, tensile strength, and wear resistance) [ 4 , 5 , 6 , 7 , 8 , 9 ]; color stability and reparability [ 10 , 11 , 12 ]; and chemical composition and biocompatibility issues (such as cytotoxicity, the materials’ interactions with oral epithelial cells, fibroblasts or dental pulp cells monomer release bacterial adhesion, biofilm formation, antimicrobial activity, and the materials’ interactions with saliva) [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. With regard to biocompatibility, the results of various tests performed on saliva samples can contribute to establishing a diagnosis in diverse local or systemic diseases and to monitoring physiological or pathological conditions.…”