Interactions between effects of environmental chemicals and natural stressors: A review

Holmstrup, Martin; Bindesbøl, Anne-Mette; Oostingh, Gertie Janneke; Duschl, Albert; Scheil, Volker; Köhler, Heinz‐R.; Loureiro, Susana; Soares, Amadeu M.V.M.; Ferreira, Abel L.G.; Kienle, Cornelia; Gerhardt, Almut; Laskowski, Ryszard; Kramarz, Paulina; Bayley, Mark; Svendsen, Claus; Spurgeon, David J.

doi:10.1016/j.scitotenv.2009.10.067

Cited by 673 publications

(481 citation statements)

References 149 publications

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“…(Hagger et al 2006;Holmstrup et al 2010). Thus, in line with our results, large scale studies show differences in biomarker ranges and baseline biomarker values among geographical areas that are mainly attributed to difference in temperature, salinity and trophic status Gagné et al 2008).…”

Section: Discussionsupporting

confidence: 90%

Biochemical biomarker responses to pollution in selected sentinel organisms across the Eastern Mediterranean and the Black Sea

Tsangaris

Moschino

Strogyloudi

et al. 2015

Environ Sci Pollut Res

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Section: Discussionsupporting

confidence: 90%

Biochemical biomarker responses to pollution in selected sentinel organisms across the Eastern Mediterranean and the Black Sea

Tsangaris

Moschino

Strogyloudi

et al. 2015

Environ Sci Pollut Res

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“…This is the first demonstration that thermal evolution may change the widespread synergism where contaminants get more toxic at higher temperatures (Holmstrup et al., 2010; Noyes & Lema, 2015). This resembles the long‐term evolutionary pattern where cold‐adapted high‐latitude populations of the damselfly I. elegans are more sensitive to zinc at 24°C compared to 20°C (hence a synergism), while warm‐adapted low‐latitude populations are not (Dinh et al., 2013).…”

Section: Discussionmentioning

confidence: 99%

“…This novel insight highlights the importance of considering in situ thermal evolution when assessing ecological risks of contaminants in a warming world (Malaj et al., 2014). More general, besides warming, many other environmental stressors may magnify the toxicity of contaminants (Holmstrup et al., 2010; Liess et al., 2016). This generates the hypothesis that evolution leading to genetic adaptation to an environmental stressor may ensure that synergistic effects between contaminants and this environmental stressor will not be present anymore.…”

Section: Discussionmentioning

confidence: 99%

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Thermal evolution offsets the elevated toxicity of a contaminant under warming: A resurrection study in Daphnia magna

Zhang

Jansen

Meester

et al. 2018

Evolutionary Applications

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Synergistic interactions between temperature and contaminants are a major challenge for ecological risk assessment, especially under global warming. While thermal evolution may increase the ability to deal with warming, it is unknown whether it may also affect the ability to deal with the many contaminants that are more toxic at higher temperatures. We investigated how evolution of genetic adaptation to warming affected the interactions between warming and a novel stressor: zinc oxide nanoparticles (nZnO) in a natural population of Daphnia magna using resurrection ecology. We hatched resting eggs from two D. magna subpopulations (old: 1955–1965, recent: 1995–2005) from the sediment of a lake that experienced an increase in average temperature and in recurrence of heat waves but was never exposed to industrial waste. In the old “ancestral” subpopulation, exposure to a sublethal concentration of nZnO decreased the intrinsic growth rate, metabolic activity, and energy reserves at 24°C but not at 20°C, indicating a synergism between warming and nZnO. In contrast, these synergistic effects disappeared in the recent “derived” subpopulation that evolved a lower sensitivity to nZnO at 24°C, which indicates that thermal evolution could offset the elevated toxicity of nZnO under warming. This evolution of reduced sensitivity to nZnO under warming could not be explained by changes in the total internal zinc accumulation but was partially associated with the evolution of the expression of a key metal detoxification gene under warming. Our results suggest that the increased sensitivity to the sublethal concentration of nZnO under the predicted 4°C warming by the end of this century may be counteracted by thermal evolution in this D. magna population. Our results illustrate the importance of evolution to warming in shaping the responses to another anthropogenic stressor, here a contaminant. More general, genetic adaptation to an environmental stressor may ensure that synergistic effects between contaminants and this environmental stressor will not be present anymore.

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“…Examples include interactions between temperature and metals impairing development of individual zebrafish (5); temperature and pesticides affecting physiological and sexual development in fish (6) and in reptiles (10); and UV-B radiation in combination with various other physical, chemical, or biological stressors having an impact on individual amphibian survival (8). However, there have been very few studies of population-level impacts due to interactions between chemicals and other environmental stressors (4,11,12). Environmental pressures on wildlife will increase with predicted scenarios for climate change, human population growth, and economic development (1).…”

Section: Discussionmentioning

confidence: 99%

Climate change and pollution speed declines in zebrafish populations

Brown

Owen

Peters

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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Endocrine disrupting chemicals (EDCs) are potent environmental contaminants, and their effects on wildlife populations could be exacerbated by climate change, especially in species with environmental sex determination. Endangered species may be particularly at risk because inbreeding depression and stochastic fluctuations in male and female numbers are often observed in the small populations that typify these taxa. Here, we assessed the interactive effects of water temperature and EDC exposure on sexual development and population viability of inbred and outbred zebrafish (Danio rerio). Water temperatures adopted were 28°C (current ambient mean spawning temperature) and 33°C (projected for the year 2100). The EDC selected was clotrimazole (at 2 μg/L and 10 μg/L), a widely used antifungal chemical that inhibits a key steroidogenic enzyme [cytochrome P450(CYP19) aromatase] required for estrogen synthesis in vertebrates. Elevated water temperature and clotrimazole exposure independently induced maleskewed sex ratios, and the effects of clotrimazole were greater at the higher temperature. Male sex ratio skews also occurred for the lower clotrimazole exposure concentration at the higher water temperature in inbred fish but not in outbred fish. Population viability analysis showed that population growth rates declined sharply in response to male skews and declines for inbred populations occurred at lower male skews than for outbred populations. These results indicate that elevated temperature associated with climate change can amplify the effects of EDCs and these effects are likely to be most acute in small, inbred populations exhibiting environmental sex determination and/or differentiation.

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Interactions between effects of environmental chemicals and natural stressors: A review

Cited by 673 publications

References 149 publications

Biochemical biomarker responses to pollution in selected sentinel organisms across the Eastern Mediterranean and the Black Sea

Biochemical biomarker responses to pollution in selected sentinel organisms across the Eastern Mediterranean and the Black Sea

Thermal evolution offsets the elevated toxicity of a contaminant under warming: A resurrection study in Daphnia magna

Climate change and pollution speed declines in zebrafish populations

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