2011
DOI: 10.4161/fly.5.4.17807
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Interactions between enhancer of rudimentary and Notch and deltex reveal a regulatory function of enhancer of rudimentary in the Notch signaling pathway in Drosophila melanogaster

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Cited by 9 publications
(9 citation statements)
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“…All of the putative binding partners of DmERH and HsERH are known nuclear proteins, which is consistent with previous studies that localized ERH to the nucleus [6, 12]. The fact that RPS3 was identified as a binding partner of ERH in both Drosophila and humans suggests a conserved function of ERH in both humans and Drosophila.…”
Section: Resultssupporting
confidence: 90%
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“…All of the putative binding partners of DmERH and HsERH are known nuclear proteins, which is consistent with previous studies that localized ERH to the nucleus [6, 12]. The fact that RPS3 was identified as a binding partner of ERH in both Drosophila and humans suggests a conserved function of ERH in both humans and Drosophila.…”
Section: Resultssupporting
confidence: 90%
“…Previous studies on the immunolocalization of ERH in Drosophila S2 cells and early embryos demonstrated that in Drosophila melanogaster endogenous ERH is nuclearly localized [12]. Those results corroborate studies in human cell lines in which EGFP-HsERH fusion proteins were localized to the nucleus [6].…”
Section: Resultssupporting
confidence: 81%
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“…Hence, the novel gene was named enhancer of rudimentary and its protein product was proposed to play some role in the regulation of pyrimidine metabolism [1]. Later, the same group suggested that ERH could be involved in the regulation of the cell cycle and cellular proliferation, and also in the regulation of the Notch signaling pathway [2,13]. In Xenopus laevis , ERH interacts with DCoH/PCD, a dimerization cofactor of the HNF1 transcription factor, acting as a transcriptional repressor, but this phenomenon seems to be tissue-specific since DCoH/PCD is detected mainly in the liver and kidneys [4].…”
Section: Introductionmentioning
confidence: 99%
“…Since its discovery (1,2), the enhancer of rudimentary gene, e(r), has been studied with respect to a role in mitosis, cell proliferation, and cancer. The e(r) gene was first shown to be expressed at high levels in oogenesis and in mitotic cells in the Drosophila embryo (2,3,4). The expression pattern in the embryo is very similar to that of cyclin E (5) and correlates with cells that are undergoing DNA synthesis (6).…”
Section: Introductionmentioning
confidence: 99%